Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark

Johannesen, Caroline Klint; Rezahosseini, Omid; Gybel-Brask, Mikkel; Kristensen, Jonas Henrik; Hasselbalch, Rasmus Bo; Pries-Heje, Mia Marie; Nielsen, Pernille B; Knudsen, Andreas Dehlbæk; Fogh, Kamille; Norsk, Jakob; Andersen, Ove; Jensen, Claus Antonio Juul; Torp‐Pedersen, Christian; Rungby, Jørgen; Ditlev, Sisse B.; Hageman, Ida; Møgelvang, Rasmus; Dessau, Ram Benny; Sørensen, Erik; Harritshøj, Lene Holm; Folke, Fredrik; Sten, Curt; Møller, Maria Elizabeth Engel; Engsig, Frederik Neess; Ullum, Henrik; Jørgensen, Charlotte Sværke; Ostrowski, Sisse Rye; Bundgaard, Henning; Iversen, Kasper; Fischer, Thea Kølsen; Nielsen, Susanne Dam

doi:10.1128/spectrum.00904-21

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…In all vaccine groups, there were participants for whom seroconversion did not occur during the 180 days of follow-up. For participants in the Convidecia and CoronaVac groups, seronegativity after the complete vaccination schedule (19 and 10%, respectively) exceeded the range of 1 to 9% reported by other authors ( 27 , 28 ).…”

Section: Discussioncontrasting

confidence: 57%

Longevity and Neutralizing Capacity of IgG Antibodies against SARS-CoV-2 Generated by the Application of BNT162b2, AZD1222, Convidecia, Sputnik V, and CoronaVac Vaccines: a Cohort Study in the Mexican Population

et al. 2023

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Since the start of the vaccination programs against COVID-19 in 2020, it was evident that due to global shortages, the demand for the dose required in Mexico could only be covered by acquiring different vaccines. Therefore, determining the effectiveness of these and the longevity of acquired immunity is extremely important in a scenario where SARS-CoV-2 circulation becomes endemic and booster doses are required periodically.

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Section: Discussioncontrasting

confidence: 57%

Longevity and Neutralizing Capacity of IgG Antibodies against SARS-CoV-2 Generated by the Application of BNT162b2, AZD1222, Convidecia, Sputnik V, and CoronaVac Vaccines: a Cohort Study in the Mexican Population

et al. 2023

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“…Data on all participants’ PCR tests for SARS-CoV-2 RNA were obtained from national registries. With few exceptions (2.4%), all HW with a positive PCR test developed antibodies [ 43 ]. As with the study from India, the design of the Danish study was different to the design of our study.…”

Section: Discussionmentioning

confidence: 99%

Cumulative Incidence of SARS-CoV-2 in Healthcare Workers at a General Hospital in Germany during the Pandemic—A Longitudinal Analysis

Platten

Nienhaus

Peters

et al. 2022

IJERPH

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Health workers (HW) are at increased risk for SARS-CoV-2 infection. In order to monitor the infection dynamic on the basis of contact with patients, HW at the St. Antonius Hospital (SAH) were tested four times in one year by PCR and serology. The cumulative incidence of infection in HW was calculated. Swab and blood tests were simultaneously performed between April 2020 and April 2021. Risk factors and demographic information were assessed at the beginning of the study. The response rate was above 75% in all rounds of testing. The study comprised 1506 HW, 165 (10.6%) of which tested positive for SARS-CoV-2 infection. Working in an ICU or on wards with patient contact were risk factors (OR 4.4, 95% CI 1.73–13.6 and OR 2.9, 95% CI 1.27–8.49). At the end of the study, the majority of HW (810 of 1363 (59.4%)) had been vaccinated at least once. A total of 29.1% of unvaccinated HW and 5.3% of vaccinated HW showed an immune response typical for natural SARS-CoV-2 infection. Of the 73 HW who provided information on the course of the disease, 31.5% reported that their quality of life continued to be impaired. The cumulative incidence of infection was low in these HW, which may be attributed to vaccination and good hygiene. Nevertheless, a work-related infection risk was identified, highlighting the need to improve protection against infection. A high risk of developing long COVID was found after the infection has subsided. Special rehabilitation programs should be provided and HW should be compensated for reduced work capacity in the case that rehabilitation fails or takes a long time.

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“…Baseline clinical information was retrieved from patients’ medical files and for healthcare personnel from questionnaires fulfilled by study subjects at study entry. We matched patients and controls by the nearest age at the time of first vaccination in a 1:1 ratio using nearest neighbour matching with the Optmatch package in R. 27 28 Continuous data were reported as medians with IQR, and differences were assessed by Mann-Whitney U test or t-test, as most appropriate. Categorical data were reported as frequency counts and percentages, and differences were evaluated using the χ 2 test or Fisher's exact test, as most appropriate.…”

Section: Methodsmentioning

confidence: 99%

Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases

et al. 2022

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IntroductionResponses to COVID-19 vaccination in patients with chronic pulmonary diseases are poorly characterised. We aimed to describe humoral responses following two doses of BNT162b2 mRNA COVID-19 vaccine and identify risk factors for impaired responses.MethodsProspective cohort study including adults with chronic pulmonary diseases and healthcare personnel as controls (1:1). Blood was sampled at inclusion, 3 weeks, 2 and 6 months after first vaccination. We reported antibody concentrations as geometric means with 95% CI of receptor binding domain (RBD)-IgG and neutralising antibody index of inhibition of ACE-2/RBD interaction (%). A low responder was defined as neutralising index in the lowest quartile (primary outcome) or RBD-IgG <225 AU/mL plus neutralising index <25% (secondary outcome), measured at 2 months. We tested associations using Poisson regression.ResultsWe included 593 patients and 593 controls, 75% of all had neutralising index ≥97% at 2 months. For the primary outcome, 34.7% of patients (n=157/453) and 12.9% of controls (n=46/359) were low responders (p<0.0001). For the secondary outcome, 8.6% of patients (n=39/453) and 1.4% of controls (n=5/359) were low responders (p<0.001). Risk factors associated with low responder included increasing age (per decade, adjusted risk ratio (aRR) 1.17, 95% CI 1.03 to 1.32), Charlson Comorbidity Index (per point) (aRR 1.15, 95% CI 1.05 to 1.26), use of prednisolone (aRR 2.08, 95% CI 1.55 to 2.77) and other immunosuppressives (aRR 2.21, 95% CI 1.65 to 2.97).DiscussionPatients with chronic pulmonary diseases established functional humoral responses to vaccination, however lower than controls. Age, comorbidities and immunosuppression were associated with poor immunological responses.

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Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark

Cited by 12 publications

References 16 publications

Longevity and Neutralizing Capacity of IgG Antibodies against SARS-CoV-2 Generated by the Application of BNT162b2, AZD1222, Convidecia, Sputnik V, and CoronaVac Vaccines: a Cohort Study in the Mexican Population

Longevity and Neutralizing Capacity of IgG Antibodies against SARS-CoV-2 Generated by the Application of BNT162b2, AZD1222, Convidecia, Sputnik V, and CoronaVac Vaccines: a Cohort Study in the Mexican Population

Cumulative Incidence of SARS-CoV-2 in Healthcare Workers at a General Hospital in Germany during the Pandemic—A Longitudinal Analysis

Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases

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