Risk factors for Barrett's oesophagus: A population-based approach

Johansson, Johan; Håkansson, Hans-Olof; Mellblom, Lennart; Kempas, Antti; Johansson, Karl‐Erik; Granath, Fredrik; Nyrén, Olof

doi:10.1080/00365520600881037

Cited by 65 publications

(96 citation statements)

References 29 publications

(36 reference statements)

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“…The prevalence of H. pylori infection in the RE group in China was highest in patients with the lowest grade of inflammation (A-grade according to Los Angeles classification). This is in contrast with our study, where this pathogen was present twice more frequently in patients with BE than in the patients with RE, which is in compliance with a very recent study of Johansson et al (2007) suggesting a synergetic effect of colonization of H. pylori and reflux for the development of BE.…”

Section: Discussioncontrasting

confidence: 57%

Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus

et al. 2007

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Reflux esophagitis (RE) and Barrett's esophagus (BE) belong to the most common esophageal complications of gastroesophageal reflux disease. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. Therefore, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and BE. GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and an additional group of 22 subjects with BE as the fourth grade of esophagitis) and 173 unrelated controls. There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between the controls and patients with RE or BE. Similarly, frequencies of GSTP1 alleles were non-significantly different between the control and RE groups. However, GSTP1 B allele carriers were more frequent among the patients with BE compared to those in the reflux esophagitis group (P = 0.04, OR = 2.10, 95% CI 0.99-4.44) and most significantly when compared to the controls (P = 0.0067, P corr < 0.05, OR = 2.56, 95%CI 1.30-5.05). Although the GSTM1 and GSTT1 genes did not show any relationship with reflux disease, the GSTP1 gene might be one of the risk factors associated with susceptibility to RE, especially to BE.

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Section: Discussioncontrasting

confidence: 57%

Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus

et al. 2007

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“…30,31 Although some previous studies have shown inverse correlation with wine use 32,33 but positive correlation with liquor use 34 and BE development, some authors have argued that alcohol itself, not the type of the different drinks, was directly related to GERD. 35 Our study found a significant relationship between BE and alcohol abuse and tobacco use, and demonstrates that BE development increases with alcohol abuse and smoking.…”

Section: Discussionmentioning

confidence: 98%

Utility of Endoscopy for Diagnosis of Barrett in a Non-Western Society: Endoscopic and Histopathologic Correlation

Ege¹,

Dinç

Yildiz

et al. 2015

International Surgery

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Barrett esophagus is metaplastic transformation of esophageal squamous epithelium to columnar cells. A total of 1370 patients who had undergone upper endoscopy because of dyspeptic complaints were enrolled in the study. Age, sex, alcohol and smoking habits, body mass index, type and duration of symptoms (heartburn, epigastric pain, nausea, vomiting), and use of proton pump inhibitors were evaluated in all patients and recorded on standardized forms. Patients were grouped as normal esophagogastric junction, long-segment Barrett esophagus, and short-segment Barrett. Biopsies were taken from at least 6 points and examined histopathologically. Of the 1370 patients involved in the study, 748 (54.6%) were female and 622 (45.4%) were male. Mean age was 47.2 6 15.30 years. Short-segment Barrett esophagus was detected in 16 patients, and long-segment Barrett was detected in 11 patients. Although Barrett esophagus was detected in 11 cases that were suspected to have Barrett during endoscopy, histopathology was negative in all cases that were not suspected to have Barrett. Barrett esophagus prevalence was significantly higher in people who used alcohol and tobacco and who had hiatal hernia. Although Barrett esophagus was detected in 40% of cases that were suspected to have Barrett during endoscopy, histopathology was negative in all cases that were not suspected to have Barrett. Barrett was detected in 40.7% of cases that were suspected to have Barrett during endoscopy; histopathology was negative in all cases that were not suspected to have Barrett. Senstivity of endoscopy is questionable in detection of short-segment Barrett.

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“…A determinant of esophageal disorders is often the presence of GERD, so the lack of information on the presence of GERD may have led authors to underestimate the role of studied beverages. 46 Moreover, population controls might have an undiagnosed BE or GERD, even though BE is rarely diagnosed among healthy volunteers and is found in less than 10% of subjects with severe reflux. 47,48 Contrasting results may be also obtained with adjustment for different confounders or when considering different temporalities of the associations.…”

Section: Modelmentioning

confidence: 99%

Association between coffee or tea drinking and Barrett’s esophagus or esophagitis: an Italian study

et al. 2017

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BACKGROUND/OBJECTIVES: Only a few papers have treated of the relationship between Barrett's esophagus (BE) or erosive esophagitis (E) and coffee or tea intake. We evaluated the role of these beverages in BE and E occurrence. SUBJECTS/METHODS: Patients with BE (339), E (462) and controls (619) were recruited. Data on coffee and tea and other individual characteristics were collected using a structured questionnaire. RESULTS: BE risk was higher in former coffee drinkers, irrespective of levels of exposure (cup per day; ⩽ 1: OR = 3.76, 95% CI 1.33-10.6; 41: OR = 3.79, 95% CI 1.31-11.0; test for linear trend (TLT) P = 0.006) and was higher with duration (430 years: OR = 4.18, 95% CI 1.43-12.3; TLT P = 0.004) and for late quitters, respectively (⩽3 years from cessation: OR = 5.95, 95% CI 2.19-16.2; TLT P o 0.001). The risk of BE was also higher in subjects who started drinking coffee later (age 418 years: OR = 6.10, 95% CI 2.15-17.3). No association was found in current drinkers, but for an increased risk of E in light drinkers (o 1 cup per day OR = 1.85, 95% CI 1.00-3.43). A discernible risk reduction of E (about 20%, not significant) and BE (about 30%, P o 0.05) was observed in tea drinkers. CONCLUSIONS: Our data were suggestive of a reduced risk of BE and E with tea intake. An adverse effect of coffee was found among BE patients who had stopped drinking coffee. Coffee or tea intakes could be indicative of other lifestyle habits with protective or adverse impact on esophageal mucosa.

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Risk factors for Barrett's oesophagus: A population-based approach

Abstract: Reflux is the predominant risk factor for BO, and proximal gastric colonization of H. pylori seems to amplify this risk.

Cited by 65 publications

References 29 publications

Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus

Polymorphisms of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett’s esophagus

Utility of Endoscopy for Diagnosis of Barrett in a Non-Western Society: Endoscopic and Histopathologic Correlation

Association between coffee or tea drinking and Barrett’s esophagus or esophagitis: an Italian study

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