Risk factors for antibiotic-resistant Escherichia coli isolated from community-acquired urinary tract infections in Dakar, Senegal

Dromigny, Jacques Albert; Nabeth, Pierre; Juergens-Behr, Ann; Perrier-Gros-Claude, Jean-David

doi:10.1093/jac/dki158

Cited by 74 publications

(74 citation statements)

References 7 publications

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“…The average prevalence found in this country was 6.5%. [15] Meanwhile the prevalence found in Cameroon was 45.3%. This result is higher than the Senegal study carried out 10 years ago.…”

Section: Discussionmentioning

confidence: 96%

Prevalence of CTX-M beta-Lactamases in Escherichia coli from community-acquired urinary tract infections and associated risk factors among women in Cameroon

Djuikoue

Njajou

Kamga

et al. 2017

JER

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Background: In recent years, a worldwide dissemination of CTX-M beta-lactamase-type in Escherichia coli strains isolates from community-acquired urinary tract infections (CA-UTI) has been observed. However little is known on the prevalence and risk factors of this global threat in developing countries. Objective: The aim of this study was to study the prevalence and risk factors for CA-UTI in Yaoundé, Cameroon. Methods: Eighty six patients with urinary E.coli infection recruited from 10 health structures in the town of Yaoundé, Cameroon. After taking the first urine, faeces were collected from the patients for the study of the intestinal flora. The sample collection of faeces was done on a selected gel of enterobacteria resistant to third generation of cephalosporin. The molecular typing of extended-spectrum β-lactamase (ESBL) was carried out. Results: Eighty-six strains of E. coli from 86 patients were included. We found that 39 (45.3%) strains produced an extendedspectrum beta-lactamase. Among risk factors, previous use of antibiotic and the dry season were associated with the presence of an ESBL-producing strain in the urine. All ESBL were identified as CTX-M. The production of CTX-M was found to be significantly associated with resistance to fluoroquinolones, aminoglycosides and to the association of trimethoprim-sulfamethazole. Conclusions: The prevalence of CTX-M ESBL in Yaoundé, Cameroon, provides new evidence on the global dissemination of CTX-M and the extent of this phenomenon in developing countries.

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“…The average prevalence found in this country was 6.5%. [15] Meanwhile the prevalence found in Cameroon was 45.3%. This result is higher than the Senegal study carried out 10 years ago.…”

Section: Discussionmentioning

confidence: 96%

Prevalence of CTX-M beta-Lactamases in Escherichia coli from community-acquired urinary tract infections and associated risk factors among women in Cameroon

Djuikoue

Njajou

Kamga

et al. 2017

JER

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“…Consequently, when urine samples are collected for laboratory tests, there may be an overrepresentation of microorganisms that do not respond to treatment. In spite of this possible bias due to recruitment of patients in a laboratory setting, we can provide information about risk factors for urinary tract infection due to E. coli strains that are resistant to antimicrobial agents that are commonly used in developing countries [8].…”

Section: Discussionmentioning

confidence: 99%

“…The aminoglycosides are Antibiotic Resistance in Pediatric Community-Acquired Urinary Infections Resistance to ampicillin and TMP/SMX has increased progressively in the last decade. In the United States, Gupta observed an increase from 7% in 1990 to 16%-18% in 1996-2001 in outpatient treatment of non-complicated UTIs [8]. This increase in the resistance rate is probably a consequence of indiscriminate use of this drug.…”

Section: Discussionmentioning

confidence: 99%

“…There is a paucity of literature concerning antibiotic therapy for uncomplicated UTI in the developing world. Increasing rates of resistance among bacterial uropathogens has caused growing concern in both developed and developing countries [8]. We evaluated the frequency of uropathogens in a community of São Paulo, Brazil, and we examined the antimicrobial susceptibility of E. coli and other uropathogens.…”

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confidence: 99%

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Antibiotic resistance patterns of pediatric community-acquired urinary infections

Guidoni¹,

Berezin²,

Nigro³

et al. 2008

Braz J Infect Dis

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Knowledge about antimicrobial resistance patterns of the etiological agents of urinary tract infections (UTIs) is essential for appropriate therapy. Urinary isolates from symptomatic UTI cases attended at Santa Casa University Hospital of São Paulo from August 1986 to December 1989 and August 2004 to December 2005 were identified by conventional methods. Antimicrobial resistance testing was performed by Kirby Bauer's disc diffusion method. Among the 257 children, E. coli was found in 77%. A high prevalence of resistance was observed against ampicillin and TMP/SMX (55% and 51%). The antibiotic resistance rates for E. coli were: nitrofurantoin (6%), nalidixic acid (14%), 1 st generation cephalosporin (13%), 3 rd generation cephalosporins (5%), aminoglycosides (2%), norfloxacin (9%) and ciprofloxacin (4%). We found that E. coli was the predominant bacterial pathogen of community-acquired UTIs. We also detected increasing resistance to TMP/SMX among UTI pathogens in this population. Key-Words: Urinary tract infection, pediatrics urinary tract infection, bacterial resistance, Escherichia coli.Urinary tract infection (UTI) is a common cause of fever and one of the most common community-acquired infections. In vitro resistance is a significant problem, not only in complicated UTIs, but also in community-acquired urinary infections. Escherichia coli is the most frequent etiological agent, accounting for 65%-90% of urinary infections [1][2][3][4]. Frequent use of wide-spectrum antibiotics may change the intestinal flora, and as a consequence, induce bacterial resistance [5,6].The American Academy of Pediatrics, the Royal College of Physicians of London and the National Guideline Clearinghouse recommend empirical and precocious treatment of UTI, based on the susceptibility standard to the antimicrobials that are habitually utilized, with the objective of reducing risks of pyelonephritic scarring [7]. There is a paucity of literature concerning antibiotic therapy for uncomplicated UTI in the developing world. Increasing rates of resistance among bacterial uropathogens has caused growing concern in both developed and developing countries [8]. We evaluated the frequency of uropathogens in a community of São Paulo, Brazil, and we examined the antimicrobial susceptibility of E. coli and other uropathogens. Additionally, we compared the antimicrobial susceptibility of E. coli between two periods. Material and Methods PatientsThe study population consisted of children younger than 17 years old, who had culture-proven UTI evaluated in the pediatrics department of Santa Casa Hospital, from August 2004 to December 2005 and August 1986 to December 1989. The exclusion criteria were previous hospitalization (<30 days), presence of catheters and vesicle continent derivation (Mitrofanoff procedure). Urine CultureEpisodes of UTI were identified by positive urine culture. Cultures were obtained from midstream-collected urine or transurethral bladder catheterization. Bacterial identification and determination of antimicrobial susceptibilit...

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“…In general, upto 95% of cases with severe symptoms are treated without bacteriological investigation. 10 Occurrence and susceptibility profiles of E. coli show substantial geographic variations as well as significant differences in various populations and environments. 11 Routine monitoring of antibiotic resistance provides data for antibiotic therapy and resistance control.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Patterns of Escherichia Coli From Various Clinical Sources

et al. 2013

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Risk factors for antibiotic-resistant Escherichia coli isolated from community-acquired urinary tract infections in Dakar, Senegal

Abstract: We hope our results will assist medical authorities in the development of appropriate control strategies.

Cited by 74 publications

References 7 publications

Prevalence of CTX-M beta-Lactamases in Escherichia coli from community-acquired urinary tract infections and associated risk factors among women in Cameroon

Prevalence of CTX-M beta-Lactamases in Escherichia coli from community-acquired urinary tract infections and associated risk factors among women in Cameroon

Antibiotic resistance patterns of pediatric community-acquired urinary infections

Antimicrobial Susceptibility Patterns of Escherichia Coli From Various Clinical Sources

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