2005
DOI: 10.1590/s0100-879x2005000500004
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Abstract: Blood transfusion in patients with sickle cell disease (SCD) is limited by the development of alloantibodies to erythrocytes. In the present study, the frequency and risk factors for alloimmunization were determined. Transfusion records and medical charts of 828 SCD patients who had been transfused and followed at the Belo Horizonte Blood Center, Belo Horizonte, MG, Brazil, were retrospectively reviewed. Alloimmunization frequency was 9.9% (95% CI: 7.9 to 11.9%) and 125 alloantibodies were detected, 79% of whi… Show more

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Cited by 60 publications
(46 citation statements)
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References 22 publications
(46 reference statements)
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“…In the present study, the risk of alloimmunization was associated with the number of blood transfusions, which agreed with the literature (12,(14)(15)(16) . The risk of alloimmunization for patients who received over 30 transfusions was statistically higher than patients who received up to 5 transfusions.…”
Section: Profile Frequencysupporting
confidence: 93%
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“…In the present study, the risk of alloimmunization was associated with the number of blood transfusions, which agreed with the literature (12,(14)(15)(16) . The risk of alloimmunization for patients who received over 30 transfusions was statistically higher than patients who received up to 5 transfusions.…”
Section: Profile Frequencysupporting
confidence: 93%
“…may show a difference in the risk of alloimmunization for older patients (9)(10)(11) . The higher frequency of alloimmunization found in this study, in comparison to other Brazilian studies, may be due to the fact that here the antibody identifi cation method used was tube and gel centrifugation, increasing diagnostic sensitivity in relation to the studies that used the tube centrifugation method only (12,13) . However, in the present study, alloimmunization rates found were lower than in international studies, which may refl ect higher phenotype compatibility between blood donors and the patients in this population.…”
Section: Profile Frequencycontrasting
confidence: 48%
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“…SCD patients require blood when there is a sickle cell crisis. Murao and Viana [16] observed 9.9% alloimmunization in SCD. Domen and Ramirez [17] have reported low rate (6.1%) of antibody formation in CRF patients undergoing dialysis while a north Indian study [1] reports 9.9% rate of antibody formation in the same category of patients.…”
Section: Discussionmentioning
confidence: 93%