Risk factors for adverse outcome in asphyxiated new born in Eastern Nepal

Yadav, Satish Kumar; Shah, G. L.; Poudel, Prakash; Mishra, Om P.

doi:10.18203/2394-6040.ijcmph20161604

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…Average duration of hospital stay of non-survivors was 4.35±2.98 days compared to 9.07±4.85 days in surviving neonates (p<0.0001). Similarly, a shorter duration of hospital stay was observed by various researchers 14,18 .…”

Section: Discussionsupporting

confidence: 64%

Risk factors for mortality in birth asphyxia of outborn neonates: A prospective observational study

Meshram

Bokade

2019

Sri Lanka J Child Health

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Background: Birth asphyxia accounts for around 23% of annual neonatal deaths in the developing world.Objective: To assess the risk factors for death in outborn neonates with birth asphyxia. Method:A one year prospective observational cohort study was undertaken in a tertiary care teaching government hospital in India. All outborn referral neonates diagnosed with birth asphyxia were included. Demographic, maternal and neonatal factors were included and analysed.Results: Incidence of birth asphyxia was 17.3% with a male: female ratio of 1.3:1. Ninety five percent mothers received antenatal care and 98% were delivered at either primary or secondary health care level institutes. Mean distance travelled by baby was 89.42±69.36 km. One hundred and twenty two (68%) mothers were anaemic, 45 (25%) had systemic hypertension and 75 (42%) had preeclampsia/eclampsia. One hundred and forty (78%) babies were term and 103 (57%) had average birth weights. A history of not crying at birth was available in 95% neonates who were resuscitated by paramedical person and medical officers. Case fatality rate was 40.6%. Average duration of hospital stay of non-survivors was 4.35±2.98 days compared to 9.07±4.85 days in surviving neonates (P<0.0001). Most deaths were in HIE stage III. Unbooked mothers (p=0.01), maternal anaemia (OR 3.07, p=0.02), neonates requiring resuscitation (OR 0.26, CI 0.10-0.68, p=0.006), neonates presenting with convulsions (OR 4.46, CI 1.46-12.16, p=0.003) or cyanosis (p<0.008), prolonged capillary refill time (OR 0.32, CI 0.47-0.82, p=0.004) and neonates in HIE stage III (OR 1.60, CI _________________________________________ 1

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Section: Discussionsupporting

confidence: 64%

Risk factors for mortality in birth asphyxia of outborn neonates: A prospective observational study

Meshram

Bokade

2019

Sri Lanka J Child Health

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“…Although birth asphyxia-related NM is a significant public health concern worldwide, developing nations, including Ethiopia, are the most affected. As per previous studies, the death rate among asphyxiated newborns ranged from 13.3% to 40.3% [13][14][15][16][17][18][19]. Different maternal and neonatal sociodemographic features, such as obstetric and health-care-related variables (home delivery, lack of ante natal follow up, spontaneous virginal delivery, premature neonates, shock during admission, severe asphyxia) were associated with mortality of asphyxiated neonates [14,15,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 77%

Birth asphyxia related mortality in Northwest Ethiopia: A multi-centre cohort study

et al. 2023

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Background Birth asphyxia is the second leading cause of neonatal death in Ethiopia, next to preterm-associated infections. Understanding the causes of death in asphyxiated newborns will help to design appropriate care. This study identifies predictors of neonatal mortality in asphyxiated newborns in selected hospitals in Northwest Ethiopia. Methods An institution-based prospective cohort study of 480 newborns with birth asphyxia was conducted at Debre Markos Comprehensive Specialized Hospital, Shegaw Motta District Hospital, and Injibara General Hospital. All newborns with asphyxia admitted to the neonatal critical care unit from the first of November 2018 to the first of November 2019 were included. Data were obtained prospectively from mothers using an interviewer’s administered questionnaire. The Kaplan-Meier survival curve was used to estimate survival time, and Log rank test was used to compare the survival curves. Bivariable and multivariable Cox proportional hazards models were fitted to identify the independent predictors of mortality in asphyxiated newborns. Adjusted hazard Ratios (AHRs) with 95% Cis (Confidence Intervals) were used to measure the strength of association and test statistical significance. Results The overall cumulative incidence of mortality among asphyxiated newborns was 42.29% (95% CI: 38%, 46). Asphyxiated neonates with other comorbidities (sepsis, neonatal anemia) (AHR = 2.63, 95% CI:1.69, 4.10), oxygen saturation of 50–69 (AHR = 4.62, 95% CI:2.55, 8.37), oxygen saturation of 70–89 (AHR = 2.82, 95% CI: 1.80, 4.42), severe Apgar score at one minute (AHR = 1.59, 95% CI:1.12, 2.25), neonates with Hypoxic Ischemic Encephalopathy (HIE) (AHR = 6.12, 95% CI:2.23, 16.75) were at higher risk of mortality. Conclusions The mortality rate among asphyxiated neonates remains high, and slightly higher than previous studies. Asphyxiated newborns with other comorbidities, severe Apgar score at one minute, who develop HIE, and low oxygen saturation were at higher risk of death. Therefore, designing appropriate interventions and prevention methods should be considered for identified variables.

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“…From the rest 94 articles, 48 were excluded as a result of not fulfilling our inclusion criteria by reviewing their titles and abstracts. Therefore, 46 full-text articles were accessed and assessed for eligibility based on the inclusion criteria [3,15,17,20,21,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71]. Finally, 13 studies that fulfilled the eligibility criteria were included in the meta-analysis (Figure 1).…”

Section: Characteristics Of Reviewed Studiesmentioning

confidence: 99%

Prevalence of perinatal asphyxia in East and Central Africa: systematic review and meta-analysis

Workineh

Semachew

Ayalew

et al. 2020

Heliyon

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Risk factors for adverse outcome in asphyxiated new born in Eastern Nepal

Cited by 5 publications

References 10 publications

Risk factors for mortality in birth asphyxia of outborn neonates: A prospective observational study

Risk factors for mortality in birth asphyxia of outborn neonates: A prospective observational study

Birth asphyxia related mortality in Northwest Ethiopia: A multi-centre cohort study

Prevalence of perinatal asphyxia in East and Central Africa: systematic review and meta-analysis

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