Risk Factors Associated With the Development of Nephropathy 10 Years After Diagnosis in Taiwanese Children With Juvenile-Onset Type 1 Diabetes—A Cohort Study From the CGJDES

Yang, C. L.; Lin, Chia-Hung; Wang, Nan-Kai; Lai, Chi-Chun; Lo, Fu‐Sung

doi:10.3389/fendo.2018.00429

Cited by 8 publications

(3 citation statements)

References 52 publications

(44 reference statements)

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“…In this study, 52.16% were female participants while 55.60% of the participants had low SES and a mean age of 15.78 ± 2.81 years, similar to previous studies in Taiwan indicating 52.5% of TID adolescents were female, 42.9% were low SES, and having a mean age of 14.90 ± 2.46 years (Lee et al, 2020). The mean BMI was 20.82 ± 3.41 kg/cm 2 in this study, which was similar to 20.1 ± 2.8 kg/cm 2 in the study of Yang et al (2018). Of our participants, 71.6% had 6‐month HbA1c levels higher than 7.5%, which was consistent with 81.9% in a previous study in Taiwan (Lee et al, 2020).…”

Section: Discussionsupporting

confidence: 90%

Pathways of emotional autonomy, problem‐solving ability, self‐efficacy, and self‐management on the glycemic control of adolescents with type 1 diabetes: A prospective study

Chen

Shu

et al. 2021

Research in Nursing & Health

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This prospective study tested a model to depict associations between a number of individual characteristics and 6‐month glycated hemoglobin (HbA1c) levels in adolescents with type 1 diabetes (T1D). Adolescents (N = 232) aged 10–19 years with T1D were recruited from a medical center in Taiwan. Demographic characteristics, emotional autonomy, problem‐solving ability, self‐efficacy at baseline, and self‐management information three months after baseline were collected using a self‐reported questionnaire. HbA1c levels 6 months after study commencement were obtained from medical records. Structural equation modeling was used to test the model. Higher baseline self‐efficacy and self‐management at 3 months were directly associated with lower 6‐month HbA1c levels. Higher baseline problem‐solving ability and self‐efficacy were directly associated with higher 3‐month self‐management, and higher baseline problem‐solving ability was directly associated with higher baseline self‐efficacy. Higher baseline emotional autonomy was directly associated with lower 6‐month HbA1c levels but indirectly associated with higher 6‐month HbA1c levels through the mediation of lower problem‐solving ability, self‐efficacy, and 3‐month self‐management. Findings indicate that improving self‐management is essential to improving subsequent glycemic control, which might be achieved by enhancing problem‐solving ability and self‐efficacy. Strengthening problem‐solving ability could diminish the negative impact of emotional autonomy on subsequent glycemic control in adolescents with T1D.

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Section: Discussionsupporting

confidence: 90%

Pathways of emotional autonomy, problem‐solving ability, self‐efficacy, and self‐management on the glycemic control of adolescents with type 1 diabetes: A prospective study

Chen

Shu

et al. 2021

Research in Nursing & Health

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“…The mean value of HbA1c in patients' with complications was 9.63% indicating poor control of diabetes. These findings are in accordance with previous studies by Yang et al (26) , Bjornstad et al (27) , and Lind et al (28) who reported that long diabetes duration, poor glycemic control and hypertension are risk factors for the development of microvascular complications as diabetic nephropathy. Moreover, there was significantly statistically difference between patients subgroups regarding cholesterol, which was increased in complicated patients (p = 0.001).…”

Section: Il29supporting

confidence: 93%

Levels of Growth Differentiation Factor 15 and Interleukin-29 in Children and Adolescents with Type 1 Diabetes Mellitus

Afify¹,

Elzoghby²,

Sarhan³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Micro-vascular complications of type 1 diabetes are characterized by damage to the microvasculature of the kidney, retina, and neurons. Some proteins are interesting in their biological functions and can be engaged in the development of micro-angiopathy such as growth/differentiation factor 15 (GDF-15) and interleukin 29 . Aim: This study aimed to investigate the diagnostic value of growth/differentiation factor 15 (GDF-15) and interleukin 29 in cases of type one diabetes and its relation to micro-vascular complications. Subjects and Methods: This study included 80 participants that were divided into 3 groups. Group 1 included 20 patients with T1DM who had micro-vascular complications, group 2 contained 20 patients with T1DM who did not have microvascular complications and group 3: 40 healthy controls. All participants were subjected to full history taking and thorough clinical examination. Laboratory investigations included HbA1c, fasting lipid profile, micro-albumin in random urine sample, eGFR calculation, GDF-15 and IL-29 assay using ELISA kit. Results: There was a statistically significant difference between patients and control group as regards GDF-15 and IL29 (p= 0.041 and 0.013, respectively) which were higher in patients group. A high statistically significant difference was found between both groups as regards levels of GDF-15, which was higher in diabetic patients with complications than patients free of complications (p= 0.001). But no statistically significant difference between both patients' groups as regards levels of IL-29 (P > 0.05). Conclusion:Our results strongly indicate that in T1DM, serum GDF-15 level might serve as a useful marker to detect micro-angiopathy such as diabetic kidney disease, peripheral neuropathy, and retinopathy.

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“…Structural changes may be observed in kidney biopsies as early as the first few years after the onset of diabetes, but the disease has a long “silent period” in its development ( 18 ). Thus, our current understanding of the trajectory of DN in children and adolescents suggests that advanced CKD and kidney failure take decades to develop after the onset/diagnosis of diabetes, which means that the data on the prevalence and time course of these outcomes in childhood-onset diabetes is largely derived from adult studies ( 19 , 20 ). This presents a dilemma for any rigorous study of diabetic kidney disease (DKD) in children and adolescents because understanding any aspect of DN, for example biomarkers, risk factors for progression, and assessment of response to interventions, has had to rely on intermediate outcomes, such as albuminuria, and hyperfiltration.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Apoptotic, Clinical, and Laboratory Parameters in Type 1 Diabetes and Early Diabetic Nephropathy: Clustering and Potential Groups Evaluation for Additional Therapeutic Interventions

Ie.a.¹

2022

Jcrpe

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Objective: Type 1 diabetes (T1D) is one of the most prevalent chronic illnesses diagnosed in childhood. Diabetic nephropathy (DN) is one of the commonest complication of T1D. Therefore the development of specific treatment that arrests progression of DN based on an individual approach would be beneficial. Analysis of criteria of apoptosis, and clinical, and laboratory characteristics in T1D and early DN in the framework of clustering may be helpful in the identification of potential groups for additional therapeutic interventions. Methods: A survey of 104 children (62 males, 42 females) with T1D and DN aged 2 to 17 years in the Endocrinology unit of Clinical Pediatric Hospital No 6 (Kyiv, Ukraine) was performed. Clinical data (age, gender, disease duration, blood pressure), conventional laboratory markers including complete blood count, serum cholesterol, hemoglobin A1c (Hb1Ac), glomerular filtration rate (GFR), and microalbuminurea (MAU), and markers of apoptosis (BcL-xL, caspase-3) and transcriptional factor HIF-1alfa were analyzed. Results: A cluster group in T1D children was characterized by somewhat higher number of platelets (PLT) - 344.9±7.88·10 9 /L, increased GFR up to hyperfiltration level 124.5±8.86 mL/min/1.73 m 2 and decreased anti-apoptotic defense - BcL-xL 144.9±2.35 a.u. was identified. Children with DN may be divided into three groups based on age, body mass index, systolic blood pressure, PLT count, erthyrocyte sedimentation rate, albumin/globulin ratio, serum cholesterol, Hb1Ac, number of diabetic ketoacidosis (DKA) episodes, GFR, MAU, HIF-1alfa, Bcl-xL, caspase-3 levels. Among children with early DN a cluster characterized by the following parameters was found: PLT count - 311.±12.05·10 9 /L, frequency of DKA episodes - 4.82±0.26 episodes/year, MAU - 112.0±10.12 mm/24 h, HIF - 200.5±3.49 a.u., BcL-xL - 128.8±3.1 a.u., and caspase-3 - 159.6±5.5 a.u. Conclusion: Thus, we hypothesize that T1D pediatric patients with increased PLT count, hyperfiltration and reduced anti-apoptotic defense may represent a group for additional therapeutic interventions, such as antioxidants along with stndard therapies to achieve optimal glycemic control. Within the DN group there was a sub-group with somewhat increased PLT count, high frequency of DKA episodes/year, high MAU, prominent increase in HIF level, prominent disturbances in apoptosis controlling factors BcL-xL and caspase-3 tht may require additional therapeutic interventions, again including antioxidants, but may additionally benefit from anti-apoptotic effectors along with optimal glycemic control, and management of hypertension and albuminuria.

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Risk Factors Associated With the Development of Nephropathy 10 Years After Diagnosis in Taiwanese Children With Juvenile-Onset Type 1 Diabetes—A Cohort Study From the CGJDES

Cited by 8 publications

References 52 publications

Pathways of emotional autonomy, problem‐solving ability, self‐efficacy, and self‐management on the glycemic control of adolescents with type 1 diabetes: A prospective study

Pathways of emotional autonomy, problem‐solving ability, self‐efficacy, and self‐management on the glycemic control of adolescents with type 1 diabetes: A prospective study

Levels of Growth Differentiation Factor 15 and Interleukin-29 in Children and Adolescents with Type 1 Diabetes Mellitus

Analysis of Apoptotic, Clinical, and Laboratory Parameters in Type 1 Diabetes and Early Diabetic Nephropathy: Clustering and Potential Groups Evaluation for Additional Therapeutic Interventions

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