Risk factors associated with striae gravidarum

Chang, Anne Lynn S.; Agredano, Yolanda Z; Kimball, Alexa B.

doi:10.1016/j.jaad.2004.05.030

Cited by 129 publications

(154 citation statements)

References 11 publications

(16 reference statements)

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“…These marks appear as erythematous bands on several parts of the body, including the abdomen, breasts, hips, and thighs. They usually start appearing from the 24th week of gestation [98]. The exact mechanism that leads to striae gravidarum is yet to be elucidated, but it is clearly related to the alteration in dynamics of skin connective tissue [99,100].…”

Section: Factors That Affect Collagen and Elastin Dynamicsmentioning

confidence: 99%

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz

Shezali

Radzi

et al. 2016

Skin Pharmacol Physiol

5,041

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Collagen and elastin networks make up the majority of the extracellular matrix in many organs, such as the skin. The mechanisms which are involved in the maintenance of homeostatic equilibrium of these networks are numerous, involving the regulation of genetic expression, growth factor secretion, signalling pathways, secondary messaging systems, and ion channel activity. However, many factors are capable of disrupting these pathways, which leads to an imbalance of homeostatic equilibrium. Ultimately, this leads to changes in the physical nature of skin, both functionally and cosmetically. Although various factors have been identified, including carcinogenesis, ultraviolet exposure, and mechanical stretching of skin, it was discovered that many of them affect similar components of regulatory pathways, such as fibroblasts, lysyl oxidase, and fibronectin. Additionally, it was discovered that the various regulatory pathways intersect with each other at various stages instead of working independently of each other. This review paper proposes a model which elucidates how these molecular pathways intersect with one another, and how various internal and external factors can disrupt these pathways, ultimately leading to a disruption in collagen and elastin networks.

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Section: Factors That Affect Collagen and Elastin Dynamicsmentioning

confidence: 99%

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz

Shezali

Radzi

et al. 2016

Skin Pharmacol Physiol

5,041

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“…They occur in all racial and ethnic groups, but are more common in dark skinned [1], young, primigravid, and obese women [2]. SG usually begin to appear in the second half of pregnancy and occur as pigmented marks in all quadrants of the abdomen.…”

Section: Introductionmentioning

confidence: 99%

Prevention of striae gravidarum with cocoa butter cream

Buchanan

Fletcher

Reid

2009

Intl J Gynecology & Obste

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“…3 Nas gestantes, as estrias ocorrem em mais de 70% das pacientes 4 e são encontradas mais comumente no abdome, no quadril, nas nádegas e nos seios. 5 Elas tendem a se desenvolver a partir da 25ª semana gestacional, 5,6 apresentam coloração eritematosa, esmaecem no puerpério e permanecem como cicatrizes prateadas. O aspecto estético é a grande preocupação para a maioria das mulheres.…”

Section: Introductionunclassified

“…As variáveis de risco clínicas e demográficas, relatadas na literatura como fatores independentes ou associados, e as conclusões são, frequentemente, conflituosas. 6 A idade materna, o tipo de pele da mãe e o peso do recém-nascido são algumas das variáveis consideradas significantes. Entretanto, outros fatores têm sido apontados, como: ganho de peso na gravidez, tendência familiar, cor dos cabelos, classe socioeconô-mica, tolerância diminuída à glicose e nutrição.…”

Section: Introductionunclassified

Estrias de distensão na gravidez: fatores de risco em primíparas

Maia

Marçon

Rodrigues

et al. 2009

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS: Estrias ocorrem em mais de 70% das gestantes. Elas tendem a se desenvolver a partir da 25ª semana gestacional. Apesar de sua etiologia não ser bem compreendida, aceita-se que a combinação de fatores genéticos com alterações endócrinas e estiramento mecânico da pele tem papel significante. Em função dos diferentes resultados encontrados na literatura, os autores avaliaram os fatores de risco comumente citados com o objetivo de determinar se estão associados com a ocorrência de estrias na gestação. OBJETIVO: Avaliar em primíparas os supostos fatores de risco para o aparecimento de estrias. MÉTODOS: Estudo observacional transversal não controlado e descritivo em primíparas. O período avaliado foi de quatro meses (janeiro a maio de 2008), em uma maternidade pública. Foram incluídas 164 primíparas de feto único após 48 horas do parto. Um total de 14 variáveis foi registrado em cada paciente. RESULTADOS: Das 164 mulheres em estudo, 59,8% desenvolveram estrias durante a gestação. Foi estatisticamente significante a associação entre a faixa etária materna (p < 0,01), o peso materno adquirido durante a gestação (p < 0,01) e o peso de recém-nascido (p = 0,01) com o aparecimento de estrias na gestação. O teste de associação utilizado foi o qui-quadrado. CONCLUSÃO: As estrias foram mais frequentes em pacientes mais jovens, nas que adquiriram maior peso na gestação e/ou nas que deram à luz bebês mais pesados. Este estudo sugere que a idade materna mais avançada poderia ser um fator protetor contra a presença de estrias na gestação. Palavras-chave: Derme; Estrias angioides; Fatores de risco; Gravidez; Primíparas Abstract: BACKGROUND: Striae occur in over 70% of pregnant women and tend to develop after 25 weeks of gestation. Despite the fact that their etiology has not yet been fully understood, it is accepted that a combination of genetic factors, endocrine alterations and mechanical stretching of skin play a significant role. Due to different results reported in the literature, the authors assessed commonly cited risk factors to determine whether they are associated with the development of striae in pregnancy. OBJECTIVE: To assess hypothetical risk factors for the development of striae in primiparous women. METHODS: This was a cross-sectional, observational, non-controlled, descriptive study with primiparous women. The study was conducted in a public maternity unit and lasted for four months (from January to May 2008). 164 primiparous women who had had a single fetus pregnancy took part in the study 48 hours after delivery. Fourteen variables were recorded for each patient. RESULTS: From the total sample, 59.8% developed striae during pregnancy. The association of maternal age range (p < 0,01), maternal weight gain during pregnancy (p < 0,01) and birth weight of newborn infants (p = 0,01) with the development of striae during pregnancy was statistically significant. The chisquared test of association was used. CONCLUSIONS: Striae were more frequently observed in younger women, in those who gained more we...

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Risk factors associated with striae gravidarum

Cited by 129 publications

References 11 publications

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Prevention of striae gravidarum with cocoa butter cream

Estrias de distensão na gravidez: fatores de risco em primíparas

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