Risk factors associated with serious bacterial infections among newborns with high body temperature

Naseh, Ali; Taleghani, Naeeme Taslimi

doi:10.15167/2421-4248/jpmh2020.61.4.1461

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…The results of this meta-analysis are in line with the results of most of the studies included in the meta-analysis. 7,[17][18][19][20][21][22][23][24] The association between PROM and neonatal sepsis may be influenced by the longer time interval between rupture of the membranes and delivery, which may lead to further complications. Dundar et al 25 reported on such complications, including respiratory distress syndrome (RDS), intraventricular hemorrhage, necrotizing enterocolitis, and neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies included in our meta-analysis on gestational age and neonatal sepsis, did not show significant differences between premature and term infants in the incidence of neonatal sepsis. 19,20,28,30,33,34 Differences in the selection of control groups or in the diagnosis of sepsis may have led to this result. Sorsa 28 reported a 39% prevalence of neonatal sepsis, which was lower than reports submitted from other countries (45.9%) because other countries used much stricter criteria to define neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

“…17,18,23,26,27,29,31,33,[37][38][39] In the remaining eight studies, the ORs were not statistically significant. [19][20][21][22]25,28,30,35 Since the data were heterogenous (I 2 =86%), a random effects model was used for analysis. We obtained a pooled OR of 2.69 (95%CI.56 to 4.65; P< 0.00001).…”

Section: Studies Included In Qualitative Synthesismentioning

confidence: 99%

“…7,9,17,18,22,24,27,29,36,39 The remaining six studies found statistically non-significant ORs. 19,20,28,30,33,34 Since the data were heterogenous (I 2 =86%), a random effects model was used for analysis. The pooled OR was 2.55 (95%CI 1.61 to 4.04; P<0.00001).…”

Section: Studies Included In Qualitative Synthesismentioning

confidence: 99%

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The association between premature rupture of membranes (PROM) and preterm gestational age with neonatal sepsis: a systematic review and meta-analysis

Andini,

Rohmawati,

Fikri

et al. 2023

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Background Sepsis is one of the main causes of neonatal mortality. The morbidity and mortality rates due to neonatal sepsis are as high as 9-20%. Premature rupture of membranes (PROM) and preterm gestational age are among the risk factors of neonatal sepsis. Objective To evaluate for potential associations between PROM as well as preterm gestational age to neonatal sepsis by meta-analysis and systematic review. Methods A meta-analysis and systematic review were performed using literature sourced from PubMed, Cochrane, and Google Scholar according to PRISMA guidelines. We calculated the incidence of sepsis in neonates with and without PROM and premature gestational age. Journal quality was assessed according to the Newcastle-Ottawa Scale (NOS) criteria. Results From the literature search for PROM, 21 case-control studies met the inclusion criteria. Neonatal sepsis was more common in neonates who had a maternal history of PROM than in those without [OR 2.69 (95%CI 1.56 to 4.65); P<0.00001]. From the literature search for gestational age, we found 17 case-control studies that met the inclusion criteria. Neonatal sepsis was more common in preterm than term neonates [OR 2.55 (95%CI 1.61 to 4.04); P<0.00001]. Conclusion Neonates with a maternal history of PROM and/or preterm gestational age are at high risk of developing neonatal sepsis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Studies Included In Qualitative Synthesismentioning

confidence: 99%

Section: Studies Included In Qualitative Synthesismentioning

confidence: 99%

See 2 more Smart Citations

The association between premature rupture of membranes (PROM) and preterm gestational age with neonatal sepsis: a systematic review and meta-analysis

Andini,

Rohmawati,

Fikri

et al. 2023

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“…Neonatal sepsis indicates bacteremia and its related clinical signs and symptoms within the first month of birth and is an important cause of neonatal mortality. Since the immune system in neonates is not fully matured (10), they are susceptible to developing infections (11)(12)(13). Sepsis occurs among 1 to 8 neonates out of 1000 live births.…”

Section: Introductionmentioning

confidence: 99%

Association Between Maternal and Neonatal Serum Vitamin D Levels and the Incidence of Early-Onset Sepsis

2021

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Background: Early-onset neonatal sepsis (EOS) is a systemic infection that occurs within the first week of life. Objectives: This study investigated the association of serum vitamin D levels in pregnant women and their neonates with the prevalence of EOS. Methods: This case-control study was performed among 50 term/late pre-term neonates admitted to our NICU due to EOS, alongside 50 healthy neonates matched for gestational age range and sex. Maternal and neonatal serum vitamin D levels were measured. The criteria for diagnosing EOS included any/combination of: respiratory, cardiovascular, hemodynamic, neurological, gastrointestinal, body temperature, or metabolic signs. For sepsis cases, CBC, CRP, blood type, blood culture, chest X ray, and in some cases, and CSF analysis and culture were tested. Mothers’ clinical history was collected. Results: Each group included 30 (60%) male and 20 (40%) female neonates. Birth weight averages were 2772 ± 667 and 3215 ± 349 grams in the case and control groups, respectively (P < 0.001). The mean serum vitamin D levels were 49.75 ± 25.53 and 56.41 ± 18.17 nmol/L in the case and control groups, respectively. The control group mothers had a significantly higher vitamin D level (68.24 nmol/L versus 55.01 in mothers of sepsis cases, p=0.005) and showed a correlation with the vitamin D levels of their neonates (R = 0.731, P < 0.001), while the data failed to show a correlation between vitamin D level in mothers and their neonates in the sepsis group (R = 0.241, P = 0.115). C-section delivery was more prevalent among the sepsis cases (P < 0.001). Conclusions: Early-onset neonatal sepsis is associated with vitamin D deficiency in neonates and their mothers, low birth weight, and being delivered by C-section.

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Possible Vertical Transmission From an Unsuspected SARS-CoV-2-Infected Mother to Her Newborn

Naseh¹,

Ashrafzadeh²

2021

Cureus

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Although the Coronavirus Disease 2019 (COVID-19) has been found to have multiple routes of transmission, limited data exist on whether the vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur from asymptomatic infected mothers to their newborns during pregnancy. We report a full-term newborn girl who was found to be positive for COVID-19 at 24 hours of life and subsequently symptomatic with fever, tachycardia, tachypnea, elevated lactate dehydrogenase, and elevated total bilirubin. The newborn was delivered by a mother who was not suspected of having COVID-19 before giving birth, but who developed fever and dyspnea five hours after delivery and was found to be positive for COVID-19. Upon further history collection, the mother reported recent mild nasal congestion in the days prior to delivery. This case highlights that the vertical transmission of COVID-19 to a newborn may occur late during the third trimester from a mother who was not suspected of having the infection. All pregnant women may need to be screened for COVID-19 symptoms, including non-specific symptoms, prior to admission for labor and delivery floors in order to perform diagnostic tests and recommended safety precautions to keep newborns and hospital personnel safe.

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Risk factors associated with serious bacterial infections among newborns with high body temperature

Cited by 3 publications

References 7 publications

The association between premature rupture of membranes (PROM) and preterm gestational age with neonatal sepsis: a systematic review and meta-analysis

The association between premature rupture of membranes (PROM) and preterm gestational age with neonatal sepsis: a systematic review and meta-analysis

Association Between Maternal and Neonatal Serum Vitamin D Levels and the Incidence of Early-Onset Sepsis

Possible Vertical Transmission From an Unsuspected SARS-CoV-2-Infected Mother to Her Newborn

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