Risk factors associated with renal insufficiency in horses with primary gastrointestinal disease: 26 cases (2000–2003)

Groover, Erin S.; Woolums, Amelia R.; Cole, Dana; LeRoy, Bruce E.

doi:10.2460/javma.228.4.572

Cited by 44 publications

(38 citation statements)

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“…In particular, an increase of 1 unit of creatinine concentration was associated with a five-fold increased probability of death, with the best specificity at >2.16 mg/dL in the ROC curve analysis performed to predict mortality upon admission. Creatinine represents an indicator of the glomerular filtration rate and the increase in its concentration in colic horses may be related to reduced renal perfusion or acute kidney injury associated with colic events (Groover et al, 2006). This could be relevant for equine colic management and prognosis and should be elucidated in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…Endotoxaemia and the serial events of the reduction of tissue perfusion, inflammation, disseminated intravascular coagulation and multiple organ dysfunction could be associated with a fatal outcome (Vandenplas et al, 2005;Groover et al, 2006;Cesarini et al, 2010). Many conditions causing equine colic can be responsible for the development of inflammation, leading to an acute phase response (APR).…”

Section: Introductionmentioning

confidence: 99%

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Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Dondi

Lukacs

Gentilini

et al. 2015

The Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Dondi

Lukacs

Gentilini

et al. 2015

The Veterinary Journal

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“…Laut einer retrospektiven Studie von Groover et al (2006) wies fast die Hälfte (79/167) der aufgrund von Kolik eingelieferten Pferde eine erhöhte SerumKreatinin-Konzentration auf. Es handelt sich bei dem ANV um ein klinisches Syndrom, welches mit einer plötzlichen Reduktion der glomerulären Filtrationsrate (GFR) einhergeht.…”

Section: Introductionunclassified

“…Dabei sind insbesondere Koliker mit Ileus-Symptomatik prädi-sponiert, eine akute Niereninsuffizienz zu entwickeln. Laut einer retrospektiven Studie von Groover et al (2006) sind vor allem Pferde mit Colitis, Reflux und Diarrhoe besonders gefährdet. Dabei kann das ANV bei den betroffenen Pferden auch nach einer gelungenen Operation und guter Erholung postoperativ zum Tod führen (Groover et al 2006).…”

Section: Introductionunclassified

Acute renal failure in horses with gastrointestinal disease

May¹,

Schmitz²,

Gehlen³

2012

PHK

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Die prärenale akute Niereninsuffizienz ist grundsätzlich reversibel. Sie kommt beim Pferd im Verlauf gastrointestinaler Erkrankungen nicht selten vor und ist eine Folge von Dehydratation, Endotoxämie und nephrotoxischen Medikamenten. Nachfolgend werden acht Pferde vorgestellt, die initial mit unterschiedlicher Koliksymptomatik in der Klinik für Pferde der FU Berlin vorgestellt wurden. In allen Fällen wurde eine akute Niereninsuffizienz mit deutlich erhöhten Harnstoff-und Kreatininwerten erkannt. Nach Detektion der Niereninsuffizienz wurde jeweils eine intensive Infusionstherapie durchgeführt. Während diese in sieben Fällen zu einer raschen Normalisierung der Nierenparameter führte, entwickelte ein Warmblutwallach, der bereits seit einer Woche Durchfall und zunehmende Apathie zeigte, aus der akuten präre-nalen Niereninsuffizienz eine intrinsische (renale) Niereninsuffizienz. Die hier beschriebenen klinischen Fälle machen deutlich, dass nur die rechtzeitige Diagnose und die früh einsetzende und adäquate Infusionstherapie den Übergang von der prärenalen in die intrinsische (renale) Niereninsuffizienz mit nachfolgender irreversibler Schädigung der Niere verhindern kann. Die Früherkennung der Niereninsuffizienz stellt sich dabei oftmals schwierig dar, da die Symptomatik meist auch mit der gastrointestinalen Grunderkrankung oder anderen postoperativen Komplikationen erklärt werden kann. Nur zielgerichtete Blutuntersuchungen (Harnstoff, Kreatinin, Nierenfunktionsanalyse) führen zu einer gesicherten Diagnose.Schlüsselwörter: Niereninsuffizienz / prärenal / Kolik / Infusionstherapie / reversibel / Gastroenterologie Acute renal failure in horses with gastrointestinal diseasePrerenal acute renal insufficiency is a reversible condition which likely occurs in the course of gastrointestinal diseases as a result of dehydration, endotoxemia and nephrotoxic medication. Eight cases presented to the Equine Clinic of the Free University Berlin with different gastrointestinal diseases are described. In all cases renal insufficiency with elevated urea and creatinine levels was detected early in its course. All cases received sufficient fluid therapy after detection of renal insufficiency until polyuria occurred. While the administration of fluids led to the normalization of renal parameters in 7 horses, prolonged hypovolemia in one (which was presented with diarrhea and apathy for a few days) had resulted in the development of intrinsic renal failure. These case reports show that early diagnosis and immediate and adequate rehydration treatment are crucial to prevent the transition from prerenal to intrinsic renal insufficiency. Intrinsic renal failure is often accompanied by irreversible impairment of the kidneys and a worse prognosis. Early detection can be a challenge as clinical symptoms are often related to the underlying gastrointestinal disease. Specific blood examinations (urea, creatinine, renal function test) are useful in establishing a diagnosis.

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“…Individual organ dysfunction has been reported in horses with acute gastrointestinal (GI) disease . Criteria for MODS in horses were proposed recently based on MODS criteria used in people, referred to herein as MODS EQ, but remain unvalidated .…”

mentioning

confidence: 99%

Scoring System for Multiple Organ Dysfunction in Adult Horses with Acute Surgical Gastrointestinal Disease

McConachie

Giguère

Barton

2016

Veterinary Internal Medicne

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BackgroundThe prevalence of multiple organ dysfunction syndrome (MODS) in horses with acute surgical gastrointestinal (GI) disease is unknown. Currently, there are no validated criteria to confirm MODS in adult horses.ObjectivesTo develop criteria for a MODS score for horses with acute surgical colic (MODS SGI) and evaluate the association with 6‐month survival. To compare the MODS SGI score with a MODS score extrapolated from criteria used in people (MODS EQ).AnimalsAdult horses that required exploratory laparotomy (n = 62) for colic. Healthy adult horses undergoing elective surgical procedures (n = 12) established the reference range of some variables.MethodsProspectively, a MODS SGI score was developed based on organ‐specific criteria established from a literature review, data collection, and clinical judgment. Data for scoring each horse were collected on Days 1 and 2 postoperatively. Horses were scored retrospectively using both scoring criteria. The prognostic performance of the MODS SGI score and its overall performance compared with the MODS EQ score were assessed with receiver operating characteristic (ROC) curve analysis.ResultsThe MODS SGI score had excellent performance for predicting 6‐month survival with an area under the ROC curve (AUC) of 0.95 (95% CI: 0.87–0.99). The AUC for the MODS SGI score was significantly higher than the MODS EQ (AUC: 0.76; 0.63–0.86).Conclusions and Clinical ImportanceThe MODS SGI score predicts 6‐month survival from discharge in horses with acute surgical colic. The MODS SGI score performed better than a score extrapolated from human scoring systems.

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Risk factors associated with renal insufficiency in horses with primary gastrointestinal disease: 26 cases (2000–2003)

Cited by 44 publications

References 6 publications

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Acute renal failure in horses with gastrointestinal disease

Scoring System for Multiple Organ Dysfunction in Adult Horses with Acute Surgical Gastrointestinal Disease

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