Risk factors associated with nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal bleeding resulting on people over 60 years old in Beijing

Chi, Tianyu; Zhu, Hongming; Zhang, Mei

doi:10.1097/md.0000000000010665

Cited by 33 publications

(28 citation statements)

References 62 publications

(52 reference statements)

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“…Moreover, some health-related behaviours, such as alcohol [ 9 ] or -we speculate- tobacco usage, if associated with NSAID consumption, could potentiate their risk of cardiovascular episodes or gastrointestinal bleeding. Thus, Chi et al observed that the proportions of patients with concomitant antiplatelet drugs, H pylori infection and status of smoking were also considerably higher in GI (gastrointestinal) bleeding group compared to non-GI bleeding group GI bleeding group associated with NSAIDs drugs [ 10 ] and Sostres et al also observed that a higher risk of upper GI bleeding was associated with current or past smoking habit and previous history of peptic ulcer [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

et al. 2018

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BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history.MethodsFour thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression.ResultsWomen consumed more non-aspirin NSAIDs (38.8% [36.7–41.0]) than men (22.3 [20.5–24.2]), but men consumed more aspirin (11.7% [10.3–13.2]) than women (5.2% [4.3–6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4–49.1) in younger than 45 to 21.1% (18.3–24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (≥75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4–31.2) in women with acute coronary syndrome, 13.3 (6.2–28.3) in women with strokes and 11.1 (7.8–15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions.ConclusionsNon-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-6019-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

et al. 2018

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“…Previously, some studies had investigated that male and previous history of diabetes were independent risk factors for non-varicose upper gastrointestinal bleeding in patients taking aspirin or other non-steroidal anti-inflammatory drugs [7][8][9][10]. It had been demonstrated that multiple comorbidities (such as hypertension, diabetes) were associated with the occurrence of GIB in elderly inpatients, rather than only a single organ failure or the combined use of multiple drugs [11].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Bleeding in Patients Admitted to Cardiology: risk factors and a new risk score

Zhang

Liu

Wang

et al. 2020

Preprint

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Background: Although the early use of a risk stratification score in gastrointestinal bleeding(GIB) is recommended, there has been no risk score for GIB in patients admitted to cardiology so far.Objective:To describe the risk factors of GIB and develop a new risk score model in patients admitted to cardiology. Methods: A total of 633 inpatients with GIB from January 2014 to December 2018 were recruited, 4,231 inpatients with non-GIB recruited as the control group. Multivariate logistic regression was used to describe the risk factors of GIB,A new risk score model was developed in the derivation cohort. Accuracy to predict GIB was assessed by the area under the receiver operating characteristic (AUROC) curve in the validation cohort.Results: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin and alanine aminotransferase(ALT) were associated with GIB . The model had a high predictive accuracy (AUROC 0.816; 95%CI, 0.792-0.839), which was supported by the validation cohort (AUROC 0.841; 95% CI, 0.807~0.874). Besides,the prediction of the model better than HAS-BLED score(AUROC 0.557; 95%CI, 0.513~0.602) and CRUSADE score(AUROC 0.791; 95%CI, 0.757~0.825), respectively. Among the inpatients with a score 0-3, 4-7, and ≥8 points, the incidence of GIB, the proportion of inpatients requiring suspended red blood cells transfusion, length of stay and in-hospital mortality all increased gradually(P< 0.001). Conclusions: Male, coronary heart disease, hypertension, stroke, systolic blood pressure, hematocrit, plasma albumin and ALT are associated with GIB. The new risk score model is an accurate risk score that predicts GIB in patients admitted to cardiology.

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“…Patient characteristics increasing the risk of NSAID-induced GI events have been identified (summarized in Table 1 ). These include: advanced age ( Fries et al, 1991 ; Hernández-Díaz and Rodríguez, 2000 ; Russell, 2001 ; Sostres et al, 2013 ; Chi et al, 2018 ); H. pylori infection ( Leontiadis and et al, 2007 ; Sostres et al, 2010 ); multimorbidity/comorbidity ( Chi et al, 2018 ; Jankovic et al, 2009 ; Weil and et al, 2000 ; Kim, 2015 ); polypharmacy ( Davies and Wallace, 1996 ) and concomitant medications ( de Abajo et al, 1999 ; Silverstein et al, 2000 ; Sorensen et al, 2000 ; Garcia Rodriguez and Hernández-Díaz, 2001 ; Johnsen et al, 2001 ; Lazzaroni and Bianchi Porro, 2001 ; Laine et al, 2002 ; de Jong et al, 2003 ; Helin-Salmivaara et al, 2007 ; Lanas et al, 2007 ; Åhsberg et al, 2010 ; Masclee et al, 2013 ; Sostres et al, 2013 ; Anglin et al, 2014 ; Olsen et al, 2020 ). Studies have shown that the risk of NSAID-induced GI complications is dose-dependent ( Silverstein and et al, 1995 ; Bombardier et al, 2000 ; Laporte et al, 2004 ; González-Pérez and et al, 2014 ; Figueiras and et al, 2016 ) and remains linear over time ( Silverstein and et al, 1995 ; Bombardier et al, 2000 ; Rostom et al, 2007 ; Goldstein et al, 2011 ).…”

Section: Nsaid-induced Upper Gastrointestinal Toxicitymentioning

confidence: 99%

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity

McEvoy

Carr

2021

Front. Pharmacol.

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Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary prevention of cardiovascular disease. Chronic non-steroidal anti-inflammatory drug use is associated with potentially serious upper gastrointestinal adverse drug reactions (ADRs) including peptic ulcer disease and gastrointestinal bleeding. A few clinical and genetic predisposing factors have been identified; however, genetic data are contradictory. Further research is needed to identify clinically relevant genetic and non-genetic markers predisposing to NSAID-induced peptic ulceration.

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Risk factors associated with nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal bleeding resulting on people over 60 years old in Beijing

Cited by 33 publications

References 62 publications

Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

Gastrointestinal Bleeding in Patients Admitted to Cardiology: risk factors and a new risk score

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity

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