Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

Abstract

BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history.MethodsFour thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression.ResultsWomen consumed more non-aspirin NSAIDs (38.8% [36.7–41.0]) than men (22.3 [20.5–24.2]), but men consumed more aspirin (11.7% [10.3–13.2]) than women (5.2% [4.3–6.3]). Consumption of non-aspirin NSAIDs decrease with age from 44.2% (39.4–49.1) in younger than 45 to 21.1% (18.3–24.2) in older than 75, but the age-pattern for aspirin usage was the opposite. Aspirin was reported by about 11% patients, as being twice as used in men (11.7%) than in women (5.2%); its consumption increased with age from 1.7% (< 45 years old) to 12.4% (≥75 years old). Aspirin was strongly associated with the presence of cardiovascular risk factors or established cardiovascular disease, reaching odds ratios of 15.2 (7.4–31.2) in women with acute coronary syndrome, 13.3 (6.2–28.3) in women with strokes and 11.1 (7.8–15.9) in men with acute coronary syndrome. Participants with cardiovascular risk factors or diseases consumed as much non-aspirin NSAID as participants without such conditions.ConclusionsNon-aspirin NSAIDs were more consumed by women and aspirin by men. The age patterns of aspirin and non-aspirin NSAIDs were opposite: the higher the age, the lower the non-aspirin NSAIDs usage and the higher the aspirin consumption. People with cardiovascular risk factors or diseases consumed more aspirin, but they did not decrease their non-aspirin NSAIDs usage.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-6019-z) contains supplementary material, which is available to authorized users.

Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany

“…As in our study, studies from Norway and Spain observed that NSAIDs use decreased with age [11,29]. This complies with guidelines recommending avoiding NSAIDs for pain management in older adults whenever possible, due to high concerns of gastrointestinal hemorrhage, cardiovascular events, and renal impairment [7,30].…”

“…Adverse effects associated with opioids, such as constipation, respiratory depression, and addiction, can present a barrier to longterm treatment [8]. In recent years, the topic of analgesics use has received much attention in Europe [9][10][11][12][13][14]. However, the existing drug utilization studies, done on analgesics use in the older German population, either include only nursing home residents [15,16] or multi-morbid older adults [17], or focus on selected analgesics [13,18].…”

Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19

“…Pre-admission NSAID use was lower in older age groups, which is in line with a recent European study of NSAID epidemiology [22]. NSAIDS account for 25% of adverse drug events reported in the United Kingdom [23], and it is thought that the elderly are more susceptible to the adverse effects of these drugs [4].…”

Effects of Drugs and Excipients on Hydration Status

“…The prevalence of regular NSAIDs consumption in the United States population has grown in recent decades, reaching values of 10.4, 11.8, and 4.4% for aspirin, non-aspirin and multiple NSAIDs, respectively [160]. Data from other countries, such as Spain, revealed higher prevalences of consumption (11.2 and 29.6% for aspirin and non-aspirin NSAIDs, respectively) [161]. However, NSAIDs consumption varies, depending on different factors, such as ethnic group, age, or sex [160,161].…”

“…Data from other countries, such as Spain, revealed higher prevalences of consumption (11.2 and 29.6% for aspirin and non-aspirin NSAIDs, respectively) [161]. However, NSAIDs consumption varies, depending on different factors, such as ethnic group, age, or sex [160,161]. Likewise, self-medicated NSAIDs consumption is widespread [162], regardless of the age group, including the polymedicated elderly and other population groups, including athletes.…”