Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study

Muntyanu, Anastasiya; Nechaev, Vladimir; Pastukhova, Elena; Logan, James; Rahme, Elham; Netchiporouk, Elena; Zubarev, Andrei; Litvinov, Ivan V.

doi:10.1016/j.lanepe.2022.100454

Cited by 8 publications

(16 citation statements)

References 41 publications

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“…Human Papilloma Virus (HPV) infection can induce the formation of cSCCs, driven by the E6 and E7 viral oncoproteins [ 141 ]. In keratinocytes infected with HPV-16, retinoid treatment repressed transcription of E6 and E7, impairing transformation [ 142 , 143 , 144 , 145 ]. Additionally, HPV-16 infected keratinocytes were sensitized to retinoid-induced growth arrest and keratinization changes compared to HPV-negative keratinocytes [ 142 ].…”

Section: The Biological Effects Of Retinoids In the Skinmentioning

confidence: 99%

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review

Ramchatesingh

Villarreal

Arcuri

et al. 2022

IJMS

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Retinoids are natural and synthetic vitamin A derivatives that are effective for the prevention and the treatment of non-melanoma skin cancers (NMSC). NMSCs constitute a heterogenous group of non-melanocyte-derived skin cancers that impose substantial burdens on patients and healthcare systems. They include entities such as basal cell carcinoma and cutaneous squamous cell carcinoma (collectively called keratinocyte carcinomas), cutaneous lymphomas and Kaposi’s sarcoma among others. The retinoid signaling pathway plays influential roles in skin physiology and pathology. These compounds regulate diverse biological processes within the skin, including proliferation, differentiation, angiogenesis and immune regulation. Collectively, retinoids can suppress skin carcinogenesis. Both topical and systemic retinoids have been investigated in clinical trials as NMSC prophylactics and treatments. Desirable efficacy and tolerability in clinical trials have prompted health regulatory bodies to approve the use of retinoids for NMSC management. Acceptable off-label uses of these compounds as drugs for skin cancers are also described. This review is a comprehensive outline on the biochemistry of retinoids, their activities in the skin, their effects on cancer cells and their adoption in clinical practice.

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Section: The Biological Effects Of Retinoids In the Skinmentioning

confidence: 99%

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review

Ramchatesingh

Villarreal

Arcuri

et al. 2022

IJMS

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“…Squamous cell carcinoma cervix is immune reactive to pancytokeratin, CK5/6, EMA, p63, p40, p16, PDL1, CEA, CK7, PAX8 or GATA3. Tumefaction is immune non-reactive to inhibin, MELCAM, HPL, Napsin A, HNF-1B, p53 or CK20 [3,4] (Figure 1 & 2).…”

Section: Medpress Psychiatry and Behavioral Sciencesmentioning

confidence: 99%

“…Carcinoma cervix requires segregation from neoplasms such as clear cell carcinoma, adenoid basal carcinoma, adenoid cystic carcinoma, small cell neuroendocrine carcinoma, carcinosarcoma, epithelioid trophoblastic tumour, immature squamous metaplasia, placental site nodule, HSIL of endo-cervical glands, sexually transmitted infections, cervical fibroid, endometriosis or cervical polyps [3,4].…”

Section: Medpress Publications Llcmentioning

confidence: 99%

“…Neoplasms of stage IB may be discerned upon radiological examination. Ultrasonography demonstrates a hypoechoic, heterogeneous tumefaction [3,4]. Colour Doppler enunciates a neoplasm with increased vascularity.…”

Section: Medpress Publications Llcmentioning

confidence: 99%

“…Colour Doppler enunciates a neoplasm with increased vascularity. Computerized tomography (CT) is optimal for assessing regional lymph node enlargement and metastatic disease [3,4]. Positron emission tomography (PET-CT) can be employed to exclude regional lymph node and distant metastases.…”

Section: Medpress Publications Llcmentioning

confidence: 99%

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Deviant and Heretical–Carcinoma Cervix

Bajaj¹

2022

MPPBS

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Cervical cancer screening utilization and its predictors among women in bench Sheko Zone, Southwest Ethiopia: using health belief model

2023

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Background Cervical cancer is the fourth most frequently diagnosed and found to be the leading cause of cancer death in women, especially in low and middle-income countries. Even though cervical cancer is a preventable disease, its preventive measures have not been equitably implemented across and within different countries; especially in low and middle-income countries, due to different contributing factors. Objective This study aimed to assess cervical cancer screening utilization and its’ predictors among Women in Bench Sheko Zone, Southwest Ethiopia. Method A community-based cross-sectional study design was employed in Bench Sheko Zone from February 2021 to April 2021. Using a multi-stage stratified sampling method, a total of 690 women in the age range of 30–49 years were included in the study. The logistic regression analysis was used considering a 95% confidence interval and a P-value of < 0.05. Results Ninety-six (14.2%) of the participants have utilized cervical cancer screening. Predictors like; age between 40–49 years (AOR = 5.35, 95% CI = [2.89, 9.90]), partner educational status of certificate and above (AOR = 4.36, 95% CI = [1.65, 11.51]), first sexual intercourse before eighteen years (AOR = 4.85, 95% CI = [2.29, 10.26]), ever used of alcohol (AOR = 3.99, 95% CI = [1.23, 12.89]), good knowledge (AOR = 8.98, 95% CI = [4.06, 19.89]), favorable attitude (AOR = 3.56, 95% CI = [1.78, 7.09]), and high perceived benefit (AOR = 2.94, 95% CI = [1.48, 5.84]) were strongly associated with cervical cancer screening utilization. Conclusion In this study, cervical cancer screening utilization was relatively low. Therefore, promotion of the perception of women towards cervical cancer screening, and provision of health-related information towards different behavioral-related factors should have to be addressed at each level of health care.

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Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study

Cited by 8 publications

References 41 publications

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review

The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review

Deviant and Heretical–Carcinoma Cervix

Cervical cancer screening utilization and its predictors among women in bench Sheko Zone, Southwest Ethiopia: using health belief model

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