Risk Factors and Angiographic Findings in Patients with LBBB Who Underwent Coronary Angiography in Duhok Heart Center

Abstract

The objectives of this study were to determine presenting symptoms, risk factors, echocardiographic and angiographic findings in patients with Left bundle branch block (LBBB), who underwent coronary angiography in Duhok heart center. All patients with symptomatic complete LBBB who attended Duhok cardiac heart center from September 15, 2007 to September 1, 2009 were included. Demographic profile such as age and sex, presenting symptoms, risk factors, echocardiographic and coronary angiographic findings were studied. The study included 75 patients, 41 patients (54.7%) were males and 34 patients (45.3%) were females with a mean age of 56 years. Male patients with LBBB have more incidences of both abnormal coronary angiography (70.3%) and three vessels disease (70%) than female patients. In our study 57.4% of patients with LBBB had hypertension. Patients with 2 or more risk factors showed a higher percentage (47.7%) of having abnormal angiography. Based on echocardiography findings, WMA constitutes the major finding (24, 32%). In the patients with CAD, there were normal ejection fraction (EF) in 7 patients (26%) and depressed EF in 20 patients (74%). In conclusion, hypertension was a major risk factor for LBBB. left anterior descending artery (LAD) artery was the most common vessel disease. Males show an overall higher degree of affection than females in regards with three vessels disease. Patients who had 2 or more risk factors had a higher percentage of having abnormal angiography. Left ventricular EF was lower in LBBB patients who had CAD.

Role of P-Selectin In Patients with Slow Coronary Flow.

“…These aggregates can further enhance activation of monocyte, facilitating activation of inflammation and thrombosis. Platelet rolling and platelet endothelial adhesion are also mediated by P-selectin expression upon platelet activation [6]. P-selectin, expressed on the activated platelets, has been found to have a prominent role in stabilization of platelet aggregates and in size determination of platelet aggregates [7].…”