Role of P-Selectin In Patients with Slow Coronary Flow.

Abstract

Objective: To evaluate role of P-selectin as a marker of platelets activation in coronary slow flow patients. Patients:A case control study, where seventy two patients underwent cardiac catheterization for suspected coronary artery disease. There were divided into patients group (primary coronary slow flow patients) and control group (normal coronary angiography). Methods:All patients were subjected to history, physical examination and laboratory investigation included CBC serum glucose, lipid profile and immune phenotyping of platelets activation (p selectin CD 62p by flow cytometery). Results:We have two groups: Group1 (patients group): Patients with primary coronary slow flow phenomenon=36 patients. Mean age of cases 49.33 ± 4.99 years with range of (34-55) years. In patients group there was 24 male and 12 female. Group II (control group): Patients with normal coronary angiography=36 patients. Mean age in control group 51.44 ± 3.36 years with range of (43-55) years. Conclusion:The results of the present study revealed that there is very high statistically significant difference in P-selectin level between group 1 (primary coronary slow flow patients) and group 2 (normal coronary angio patients) and there is statistically significant association between P-selectin and TIMI frame count in coronary slow flow.