Risk associations of melanoma in a Southern European population: results of a case/control study

Nikolaou, Vasiliki; Sypsa, Vana; Stefanaki, Irene; Gogas, Helen; Papadopoulos, Othon; Polydorou, Dorothea; Plaka, M.; Tsoutsos, Dimosthenis; Dimou, Anastasia; Mourtzoukou, Eleni G.; Korfitis, Chrysovalantis; Hatziolou, E.; Antoniou, Christina; Hatzakis, Angelos; Katsambas, Andreas; Stratigos, Alexander J.

doi:10.1007/s10552-008-9130-0

Cited by 37 publications

(44 citation statements)

References 39 publications

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“…A Norwegian study described a latitude gradient for MM with decreasing incidence with increasing latitude [9, 10]; the same result was found in Sweden, for both general population [11] and children [12], and in Australia [13]. MM incidence increased at lower latitude [14] also among non-Hispanic whites in the USA.…”

Section: Introductionmentioning

confidence: 72%

Relationship between Latitude and Melanoma in Italy

et al. 2012

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Objective. Evaluate the ecological relationship between skin melanoma epidemiology and latitude in Italy. Methods. We used data from the Italian network of cancer registries (Airtum). In a Poisson model, we evaluated the effect on incidence, mortality, and survival of latitude, adjusting for some demographic, social, phenotypic, and behavioural variables. Results. Incidence increased in Italy by 17% for each degree of increase in latitude. The effect of latitude was statistically significantly present also adjusting for other variables (incidence rate ratio = 1.08). The effect of latitude on increasing mortality (mortality rate ratio = 1.27) and improving survival (relative excess risk of death = 0.93) was no longer present in the multivariate model. Conclusion. Melanoma incidence, mortality, and survival vary in Italy according to latitude. After adjustment for several confounders, incidence still grows with growing latitude. Presumably, latitude expresses other variables that might be related to individual susceptibility and/or local care.

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Section: Introductionmentioning

confidence: 72%

Relationship between Latitude and Melanoma in Italy

et al. 2012

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“…In general, cancer registries do not collect information regarding duration of residence at this address, nor any residential history information; thus average annual UVR at place of diagnosis may not necessarily correlate with exposure in earlier life which may be most relevant to melanoma development (34–36). We also were unable to analyze time trends in melanoma incidence by UVR exposure, since National Oceanic and Atmospheric Association (NOAA)-derived measures were only reliable for more recent time periods.…”

Section: Discussionmentioning

confidence: 99%

Interaction of Area-Level Socioeconomic Status and UV Radiation on Melanoma Occurrence in California

Clarke

Moy

Swetter

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Melanoma incidence has been correlated strongly and positively with both socioeconomic status (SES) and lower latitude and other measures of ambient UV radiation (UVR). However, because high-SES populations may be colocated in areas of high UVR, we assessed their joint influences on melanoma occurrence to better target subpopulations for melanoma education and screening.Methods: We obtained from the California Cancer Registry information regarding 23,564 incident cases of invasive cutaneous melanoma among non-Hispanic white residents between January 1, 1998, and December 31, 2002. We geocoded each case based on residence at diagnosis and linked previously tested neighborhood measures of SES and average annual UVR to calculate age-adjusted incidence rates, rate ratios, and the corresponding 95% confidence intervals. Poisson regression was used to calculate multivariately adjusted rate ratios.Results: UVR was significantly and positively associated with melanoma incidence only among persons living in the top 40% of California neighborhoods ranked by SES. People in neighborhoods of the highest SES and UVR categories had 60% higher rates of melanoma than those from neighborhoods in the lowest categories (rate ratio, 1.60; 95% confidence interval, 1.02-2.51).Conclusion: Our findings indicate that UVR and SES interact to influence melanoma occurrence and suggest that socioeconomic gradients in melanoma incidence are not explained entirely by UVR.Impact: Cancer prevention and early detection educational efforts should be targeted to high-SES groups in areas of high UVR exposure. Contextual measures of both SES and UVR should be considered important determinants of melanoma occurrence in future studies.

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“…With respect to nevi, Holly et al13 reported relative risks of 1.6 for patients with 11–25 nevi, 4.4 for 26–50 nevi, 5.4 for 51–100 nevi and 9.8 for ≥100 nevi, and relative risks of 3.8 for 1–5 atypical nevi and 6.3 for ≥6 atypical nevi. Additional risks are associated with having fair skin (4-fold),14 red hair and blue eyes (2-fold),15 history of non-melanoma skin cancer (2–3 fold),16,17 and history of sunburns or excessive UV exposure (2-fold)18 including indoor tanning (2–3 fold) 19. Other important aspects to consider are age and sex, as risk increases with age and men have higher melanoma incidence than women,20 and changing or new nevi are more likely to be melanoma in patients over age 50 21.…”

Section: Screeningmentioning

confidence: 99%

Strategies for early melanoma detection: Approaches to the patient with nevi

Goodson¹,

Grossman²

2009

Journal of the American Academy of Dermatology

159

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Given its propensity to metastasize, and lack of effective therapies for most patients with advanced disease, early detection of melanoma is a clinical imperative. Although there are no non-invasive techniques for definitive diagnosis of melanoma, and the "gold standard" remains biopsy with histologic examination, a variety of modalities may facilitate early melanoma diagnosis and the detection of new and changing nevi. This article reviews general clinical principles of early melanoma detection, and various modalities that are currently available or on the horizon, providing the clinician with an up-to-date understanding of management strategies for their patients with numerous or atypical nevi.Learning objectives-At the conclusion of this learning activity, participants should: 1) understand the clinical importance of early melanoma detection; 2) appreciate the challenges of early melanoma diagnosis and which patients are at highest risk; 3) know general principles of early melanoma detection; 4) be familiar with current and emerging modalities that may facilitate early melanoma diagnosis and the detection of new and changing nevi; 5) know the advantages and limitations of each modality; and 6) be able to practice a combined approach to the patient with numerous or clinically atypical nevi.

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Risk associations of melanoma in a Southern European population: results of a case/control study

Cited by 37 publications

References 39 publications

Relationship between Latitude and Melanoma in Italy

Relationship between Latitude and Melanoma in Italy

Interaction of Area-Level Socioeconomic Status and UV Radiation on Melanoma Occurrence in California

Strategies for early melanoma detection: Approaches to the patient with nevi

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