Risk assessment of hepatotoxicity among tuberculosis and human immunodeficiency virus/AIDS-coinfected patients under tuberculosis treatment

Ngouleun, Williams; Nya, Prosper Cabral Biapa; Pieme, Anatole Constant; Telefo, Phélix Bruno

doi:10.1016/j.ijmyco.2016.05.003

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…On the same token history of alcohol intake was not found to be significantly associated with hepatotoxicity. A similar finding was reported from Brazil and Jimma Ethiopia [3, 5], whereas a study from Loum District Hospital and Cameroon found a history of alcohol intake as one risk factor [7, 13]. This might be ascribable to the fact that the risk of hepatotoxicity depends on the amount of alcohol intake and in the current study the amount of alcohol intake was not studied.…”

Section: Discussionsupporting

confidence: 85%

“…The effect of different factors such as age, sex, BMI, alcohol intake, type of TB, adherence, CD4+ count were assessed and lower BMI (≤ 18.5 kg/m 2 ), and presence of extrapulmonary TB were associated with an increase in drug induced hepatotoxicity. BMI of less than 18.5 kg/m 2 was mentioned as a factor in Jimma [3], whereas a study elsewhere did not found malnutrition as a factor [4, 13]. This significant association could be explained by derangement and disruption of drug metabolism pathways during protein-energy malnutrition including the acetylation pathways involved in isoniazid metabolism [7], possible depletion of glutathione stores, which makes patients more vulnerable to oxidative injuries, and the slower pace at which the liver metabolize drugs [3].…”

Section: Discussionmentioning

confidence: 99%

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Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

2020

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ObjectivesAnti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence and associated factors of drug-induced hepatotoxicity among tuberculosis and human immunodeficiency virus co-infected patients in Dessie referral hospital northeast Ethiopia.ResultsIn this cross-sectional study 84 patients were enrolled retrospectively. Data from September 1/2015 to August 30/2018 were extracted from March 1/2019 to April 1/2019. Association between dependent and independent variables was determined using the odds ratio and a P value of < 0.05 was considered as statistical significance. Out of 84 patients, 17 patients developed drug-induced hepatotoxicity which makes the prevalence of drug-induced hepatotoxicity 20.2%. The result revealed that the presence of disseminated or extrapulmonary tuberculosis [(AOR: 7.728, 95% CI (1.516–39.404)] and/or body mass index less than 18.5 kg/m2 [(AOR = 5.593, 95% CI (1.180–26.519)] were a risk factor for drug-induced hepatotoxicity. Tuberculosis and human immunodeficiency virus co-infected patients with extra- pulmonary tuberculosis and/or body mass index less than 18.5 kg/m2 should be closely followed and supervised for the development of hepatotoxicity.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

2020

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“…It was analyzed that advanced age as a risk factor for hepatoxicity and found that patients over 60 years old had a prevalence in these cases, due to physiological changes and increased risk of drug toxicity [23]. In turn, it was assessed that the risk of hepatotoxicity in HIVcoinfected patients, concluding that advanced age (over 45 years), HIV / AIDS status and regular alcohol consumption were identified as factors that aggravate the occurrence of hepatotoxicity when taking TB medications [33].…”

Section: Class 1-association Of Hepatotoxicity and Appearance Of Liver Diseasementioning

confidence: 99%

Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review

Aguiar

Carvalho

Bendelaque

et al. 2021

JPRI

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Objective: To analyze the toxicological effects of anti-tuberculosis chemotherapy in adults in national and international literature in the period from 2015 to 2020. Methodology: It is a qualitative descriptive research, of the type Integrative Literature Review (ILR). In the VHL databases PubMed / Medline, Arca, Web of Science, Microsoft Academic and Cochrane Library. Data analysis was performed with the aid of the IRaMuTeQ software. Results: 36 articles were found in which the following categories were created: 1) Association of hepatotoxicity and appearance of liver damage; 2) The incidence of adverse events related to antituberculin therapy; 3) Risk factors of regular consumption of antituberculins; 4) Intensive renal treatment for patients with nephrotoxicity. Conclusion: in our review we identified that the elderly, HIV positive and alcohol users are more likely to have toxicological effects during treatment, which can lead to a possible abandonment of treatment.

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“…Ali et al juga melaporkan proporsi pasien yang serupa di mana proporsi drug induced liver disease (DILI) akibat OAT pada kelompok gizi kurang lebih besar daripada kelompok gizi cukup dengan uji chi-square yang tidak signifikan (p>0,05) (29). Ketiga penelitian ini sesuai dengan teori yang ada menyatakan bahwa pasien dengan IMT yang lebih rendah berisiko mengalami cedera oksidatif akibat menurunya glutation yang berperan dalam sistem kekebalan tubuh, regenerasi sel, aktivitas antioksidan, serta antitoksin (30).…”

Section: Hasil Dan Diskusiunclassified

Faktor resiko kejadian peningkatan kadar transminase pada penggunaan obat antituberkulosis pasien tuberkulosis paru di RST Wijayakusuma Purwokerto

Dasuki

Muti

Yusmaini

2020

JFI

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Kasus penyakit tuberkulosis terbanyak yang dilaporkan di Indonesia terdapat di provinsi dengan kepadatan penduduk yang tinggi termasuk Jawa Tengah. Kombinasi obat antituberkulosis lini pertama yaitu pirazinamid, isoniazid, dan rifampisin berpotensi menyebabkan hepatotoksitas yang ditandai oleh peningkatan kadar transaminase. Insiden peningkatan kadar transaminase ini menyebabkan resistensi obat dan kegagalan terapi. Penting untuk mendeteksi dini peningkatan kadar transaminase oleh obat antituberkulosis dengan cara mempelajari faktor risiko predisposisinya. Tujuan penelitian adalah meneliti hubungan antara faktor resiko kejadian peningkatan kadar transaminase akibat penggunaan obat antituberkulosis pada pasien tuberkulosis paru yang ada di RST Wijayakusuma Purwokerto. Jenis penelitian ini adalah studi analitik observasional dengan desain cross-sectional. Sebanyak 80 sampel dipilih secara random sampling. Pengumpulan data dilakukan dengan melihat dan mencatat di rekam medis pasien. Data dianalisis menggunakan uji Chi-squared dan uji Regresi Logistik. Hasil analisis bivariat dengan uji Chi-Square didapatkan bahwa terdapat hubungan yang signifikan antara usia lanjut (p=0,000), jenis kelamin perempuan (p= 0,035), gizi kurang (0,000), lama pengobatan (p=0,026) dan riwayat konsumsi obat lain (p=0,008). Faktor yang paling berhubungan peningkatan kadar transaminase akibat konsumsi OAT pada pasien TB paru di RST Wijayakusuma Purwokerto adalah usia (OR=8,815) diikuti oleh status gizi (OR=6,478).

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Risk assessment of hepatotoxicity among tuberculosis and human immunodeficiency virus/AIDS-coinfected patients under tuberculosis treatment

Cited by 7 publications

References 7 publications

Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia

Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review

Faktor resiko kejadian peningkatan kadar transminase pada penggunaan obat antituberkulosis pasien tuberkulosis paru di RST Wijayakusuma Purwokerto

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