Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review

Abstract

Objective: To analyze the toxicological effects of anti-tuberculosis chemotherapy in adults in national and international literature in the period from 2015 to 2020.
 Methodology: It is a qualitative descriptive research, of the type Integrative Literature Review (ILR). In the VHL databases PubMed / Medline, Arca, Web of Science, Microsoft Academic and Cochrane Library. Data analysis was performed with the aid of the IRaMuTeQ software.
 Results: 36 articles were found in which the following categories were created: 1) Association of hepatotoxicity and appearance of liver damage; 2) The incidence of adverse events related to antituberculin therapy; 3) Risk factors of regular consumption of antituberculins; 4) Intensive renal treatment for patients with nephrotoxicity.
 Conclusion: in our review we identified that the elderly, HIV positive and alcohol users are more likely to have toxicological effects during treatment, which can lead to a possible abandonment of treatment.