Risk assessment, development and validation of a GC‐ECD‐based method for the quantification of cypermethrin from green pea

Abstract

The present work describes the persistence, dissipation behaviour, half‐life, risk assessment and novel gas chromatography method for the residue estimation of cypermethrin in green pea by spraying cypermethrin 10EC at 50 g a.i. ha−1 at fruiting stage followed by another application at a 10 day interval. The sample extraction and cleanup was followed bya modified quick, easy, cheap, effective, rugged, and safe method, and the residues of cypermethrin were determined using a validated gas chromatography method. The initial deposits were found to be 1.21 mg kg−1 following the application of insecticide at 50 g a.i. ha−1. Cypermethrin residues declined to below the detection limit of 0.05 mg kg−1 after 15 days at the recommended dosage. The half‐life of cypermethrin was 2.66 days at 50 g a.i. ha−1. For risk assessment studies, the waiting period of 15 days is recommended as safe for consumption for the insecticide. The GC‐ECD method was validated according to the SANTE guidelines by various analytical parameters including linearity, accuracy, detection and quantification limits. The developed method is simple, selective and repeatable, and can be used for the standardization of pesticides on fruits and vegetables.

Dissipation kinetics, risk assessment, and waiting period of spiromesifen on chili fruits using gas chromatography–electron capture detector

“…The average per capita daily consumption of vegetables in India is 200 g (Anonymous, 2012), of which the proportion of green chilies in the daily diet is a maximum of 5% (10 g day −1 ). Therefore, the TMRC has been calculated by multiplying the residue level with the daily consumption of chili (Jan et al, 2018, 2022; Wani et al, 2022; Wani, Dar, et al, 2019; Wani, Jan, et al, 2019). During the experimental period, the TMRC values were found to be 0.01212 and 0.01207 mg person −1 day −1 and 0.01953 and 0.01948 mg person −1 day −1 for maximum and average spiromesifen residues at the recommended dose (96 g. a.i.…”

Simultaneous quantification of losartan potassium and its active metabolite, EXP3174, in rabbit plasma by validated HPLC–PDA

“…The peak purity values of LP, EXP3174 and internal standard (valsartan) were found to be >997 (ideal value, 1,000), which shows that the peak was pure with no co‐eluting or interfering substances. This proves that method is specific (Jan et al, 2022).…”

Development and validation of gas chromatography with electron capture detection method using QuEChERS for pesticide residue determination in cucumber

“…In addition, electron capture detectors are widely available in both research and commercial laboratories (Biswas et al, 2019;Tankiewicz, 2019). In continuation of the previous reports (Bhat et al, 2019;Dar et al, 2019Dar et al, , 2022Fayaz et al, 2018;Jan et al, 2022;Singh et al, 2018;Wani et al, 2019), the aim of the present study was to develop an analytical procedure for routine analysis and simultaneous determination of selected electronegative pesticides in vegetables with high water concentration. For extraction, a modified QuEChERS sample preparation method was used and optimized.…”

“…They are one of the main sources of contaminants in water, vegetables, and fruits with serious risks to human and animal health. In addition, they cause changes in the ecosystem with harmful consequences for the environment and agriculture; the emergence and spread of new pests and diseases results in the need for using more pesticides (Dar et al, 2018; Jan et al, 2022). The continuous and indiscriminate use of pesticides and their longer period of persistence have resulted in the accumulation of residues in the terrestrial and aquatic ecosystem (Rizwan et al, 2022).…”