Risk analysis of early childhood eczema

Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age

“…Even though these are common comorbidities, the extrapolation of risk factors between these disorders is probably not justified. 29 Our finding of an inverse association between early bacterial diversity and the development of allergic sensitization is consistent with the other 2 available reports, 30,31 but not 3 others. [32][33][34] In the latter studies, sensitization was assessed in infancy, when very few children are sensitized, reducing the power for such association analyses.…”

Increased risk of eczema but reduced risk of early wheezy disorder from exclusive breast-feeding in high-risk infants

“…Our previous conventional cross-sectional analysis at 3 years of age raised suspicion that duration of exclusive breast-feeding increased risk of eczema with an odds ratio of 2.80 (95% CI 0.87-9.03), but this was not statistically significant (P 5 .10). 10 Furthermore, as in other previous studies, this observed trend could be biased from inverse causality-that is, disease-related modification of exposure-as well as a number of other methodologic issues that often confound such complicated interrelations. Typically, mothers may prolong breast-feeding after debut of eczema or wheeze in an infant because of the common perception of a protective effect from breast-feeding.…”

“…20 We previously described the development of skin lesions in detail. 10,21,22 Wheezy episode Wheeze was recorded by the parents in daily diaries since the first month of life. The term wheeze was explained to the parents as wheeze or whistling sounds, breathlessness, or recurrent troublesome cough severely affecting the well being of the infant.…”

Polyunsaturated fatty acid content of mother’s milk is associated with childhood body composition

“…The COPSAC cohort has previously been described in detail (32,33). A total of 411 infants of asthmatic mothers were enrolled at the age of 1 mo.…”