Risk analysis and an alternative protocol for reduction of screening for retinopathy of prematurity

Yang, Michael B.; Donovan, Edward F.

doi:10.1016/j.jaapos.2009.10.002

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…However, in studies from the United States, black race has been shown to be associated with a lower likelihood for the development of SROP, a finding that is supported by the current study. 9–11,26 This observation initially seemed to contradict our hypothesis that lower light exposure in utero increases the risk of SROP. However, in model 1, which evaluated the risk of all eyes in the cohort developing SROP, black race and ADL were independent predictors.…”

Section: Discussionmentioning

confidence: 88%

“…We retrospectively analyzed only complete years (1998–2002) of a previously described cohort of premature infants with a birth weight (BW) of 401 to 1250 g who were admitted to the neonatal intensive care unit of the University of Cincinnati Medical Center. 9,10 Some infants required additional care and were transferred to Cincinnati Children's Hospital Medical Center. Infants discharged from the hospital typically received eye examinations as outpatients at Cincinnati Children's Hospital Medical Center.…”

Section: Methodsmentioning

confidence: 99%

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Length of Day during Early Gestation as a Predictor of Risk for Severe Retinopathy of Prematurity

et al. 2013

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Purpose Fetal mice require light exposure in utero during early gestation for normal vascular development in the eye. Because angiogenic abnormalities in retinopathy of prematurity (ROP) are manifested in preterm infants, we investigated whether day length during early gestation was associated with severe ROP (SROP). Design Single-center, retrospective cohort study. Participants We included a total of 343 premature infants (401–1250 g birth weight [BW], from 1998–2002): 684 eyes (1 eye each of 2 patients excluded) with 76 eyes developing SROP, defined as (1) classic threshold ROP in zone I or II, (2) type 1 ROP in zone I, or (3) in a few eyes, type 1 ROP in posterior zone II that was treated. Methods For each infant, average day length (ADL) was calculated during different cumulative time periods and time windows after the estimated date of conception (EDC). Multiple logistic regression analysis (with generalized estimating equations to account for inter-eye correlation) was performed. Main Outcome Measures Association of ADL during early gestation with SROP. Results In a model evaluating all 684 eyes with 76 eyes developing SROP, BW, gestational age, multiple births, race, per capita income in the mother's residence ZIP code, and ADL during the first 90 days after the EDC were factors associated with the development of SROP. Each additional hour of ADL (90 days) decreased the likelihood of SROP by 28% (P = 0.015; odds ratio [OR], 0.72; 95% confidence interval [CI], 0.55–0.94). In a model evaluating the subset of 146 prethreshold ROP eyes with 76 eyes developing SROP, each additional hour of ADL during the first 105 days after the EDC decreased the likelihood of SROP by 46% (P = 0.001; OR, 0.54; 95% CI, 0.37–0.78). Time windows when ADL was most closely associated with SROP were 31 to 60 days and 61 to 90 days after the EDC for the all eyes and the prethreshold ROP eyes models, respectively. Conclusions Higher ADL during early gestation was associated with a lower risk for SROP and may imply a role for prophylactic light treatment during early gestation to decrease the risk of SROP. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.

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Section: Discussionmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Length of Day during Early Gestation as a Predictor of Risk for Severe Retinopathy of Prematurity

et al. 2013

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“…The effects of several risk factors on the clinical outcomes of ROP have been investigated, including birth history (gestational age and birth weight), postdelivery care (oxygen exposure and infection), and ROP care (screening and treatment) [1,2,4,5]. ROP treatment has now shifted from cryotherapy to laser photocoagulation [3,6,7].…”

Section: Introductionmentioning

confidence: 99%

Refractive Error in Patients with Retinopathy of Prematurity after Laser Photocoagulation or Bevacizumab Monotherapy

Kuo

Sun²,

Chung³

et al. 2015

Ophthalmologica

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Purpose: To evaluate the refractive development of premature infants with retinopathy of prematurity (ROP) after treatment with laser photocoagulation or intravitreal injection of bevacizumab (IVB). Methods: The medical records of patients with ROP treated between 2003 and 2012 who underwent yearly follow-ups were retrospectively reviewed. Patients with residual ROP abnormalities were excluded. The cycloplegic refraction at 3 years of age, assessed using an autorefractometer, was recorded. Results: In total, 54 eyes from 54 patients were enrolled. Patients were divided into 4 groups: group 1, including 14 eyes of 14 patients treated with laser therapy; group 2, 15 eyes of 15 patients treated with IVB; group 3, 13 eyes of 13 patients with non-type 1 ROP under conservative follow-up, and group 4, 12 eyes of 12 premature patients without ROP. The mean spherical equivalent at 3 years of age was -1.71 ± 1.27 dpt in group 1, -1.53 ± 2.20 dpt in group 2, 0.63 ± 1.37 dpt in group 3, and 0.41 ± 1.95 dpt in group 4. The mean refractive error differed significantly among the 4 groups (p < 0.001). Patients in groups 1 and 2 were more prone to myopia compared with those in groups 3 and 4. Furthermore, patients with type 1 ROP treated by laser photocoagulation (group 1) and those treated by IVB (group 2) had similar refraction (p = 1). Conclusions: The results of this study suggest that treatment-demanding ROP eyes are susceptible to more severe myopia with age compared with eyes without ROP or those with spontaneously regressed ROP. In addition, the myopic status between laser and IVB treatment did not differ statistically.

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“…One model validation study 17 met the criteria for level I evidence. One model development study, 18 and 2 model validation studies 14,19 met the criteria for level II evidence. The remaining 19 studies were categorized as level III.…”

Section: Description Of Evidencementioning

confidence: 99%

Clinical Models and Algorithms for the Prediction of Retinopathy of Prematurity

et al. 2016

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Risk analysis and an alternative protocol for reduction of screening for retinopathy of prematurity

Cited by 11 publications

References 33 publications

Length of Day during Early Gestation as a Predictor of Risk for Severe Retinopathy of Prematurity

Length of Day during Early Gestation as a Predictor of Risk for Severe Retinopathy of Prematurity

Refractive Error in Patients with Retinopathy of Prematurity after Laser Photocoagulation or Bevacizumab Monotherapy

Clinical Models and Algorithms for the Prediction of Retinopathy of Prematurity

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