Clinical Models and Algorithms for the Prediction of Retinopathy of Prematurity

Hutchinson, Amy K.; Melia, Michele; Yang, Michael B.; VanderVeen, Deborah K.; Wilson, Lorri B.; Lambert, Scott R.

doi:10.1016/j.ophtha.2015.11.003

Cited by 48 publications

(39 citation statements)

References 43 publications

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“…We observed that the model combining LCC, CPAP, GA and BW was significantly better than the model combining GA and BW for the prediction of TR-ROP both among all infants and among infants with any degree of ROP. We also calculated AUCs using the ROPScore and the CHOP model from among the various predictive models for ROP because their parameters could be extracted from our data base 11, 39 . The prediction of TR-ROP from all infants was not improved by using the ROPScore or CHOP model alone compared to the model using GA and BW.…”

Section: Discussionmentioning

confidence: 99%

Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis

Arima

Tsukamoto

Fujiwara

et al. 2017

Sci Rep

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AbstractsVisual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the efficiency of significant predictors compared with existing predictive models, ROPScore and CHOP model. Multivariable logistic regression analyses supported the following factors were useful for predicting TR-ROP from all infants and infants with any ROP: GA (odds ratio [OR], 0.47 and 0.48), history of late-onset circulatory collapse (LCC) (OR, 2.76 and 2.44) and use of continuous positive airway pressure (CPAP) at 35 weeks of postmenstrual age (OR, 3.78 and 4.50). The comparison of areas under receiver operating characteristic curves indicated the combination of LCC, CPAP and ROPScore was better than ROPScore to predict TR-ROP from all infants and infants with any ROP (P = 0.007 and 0.02) and the combination of LCC, CPAP and CHOP model was also better than CHOP model to predict TR-ROP from all infants and infants with any ROP (P = 0.01 and 0.02). Our results suggested infants with a history of LCC and a long CPAP support have a high incidence of TR-ROP.

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Section: Discussionmentioning

confidence: 99%

Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis

Arima

Tsukamoto

Fujiwara

et al. 2017

Sci Rep

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“…(137) Although several studies were performed in the US and throughout the world assessing algorithms that included infant weight gain, only one study was deemed to provide sufficient evidence. (87) The American Academy of Ophthalmology concluded that additional research was needed to optimize ROP predictive model development before models were used widely to reduce the burden of ROP screening examinations(87). …”

Section: Change In Clinical Concepts Diagnosis and Management Imentioning

confidence: 99%

Advances in understanding and management of retinopathy of prematurity

Hartnett

2017

Survey of Ophthalmology

115

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The understanding, diagnosis and treatment of retinopathy of prematurity (ROP) have changed in the last seventy years since the original description of retrolental fibroplasia associated with high oxygenation. It is now recognized that ROP differs in appearance world-wide and as ever smaller and younger premature infants survive. New methods are being evaluated to image the retina, diagnose severe ROP, and determine windows of time for treatment to save eyes and improve visual and neural outcomes. New treatments to promote physiologic retinal vascular development, vascular repair, and inhibit vasoproliferation by regulating proteins involved in vascular endothelial growth factor, insulin-like growth factor, or erythropoietin signaling. Reducing excessive oxidative/nitrosative stress and understanding progenitor cells and neurovascular and glial vascular interactions are being studied.

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“…However, these efforts will have no effect on the lack of available ophthalmologists for treatment, [61][62][63] and studies are still evaluating its widespread use. 64 However, it remains to be seen if efforts to address screening burden will also address the lack of qualified ophthalmologists to provide appropriate treatment. 2,59 In some cases, despite early laser therapy or in those infants in whom late recognition of the disease occurred, ROP can progress to retinal detachments and other complications.…”

Section: Complications Of Retinopathy Of Prematuritymentioning

confidence: 99%

The Role of Anti-vascular Endothelial Growth Factor Agents in the Management of Retinopathy of Prematurity

Conrady¹,

Hartnett²

2017

US Ophthalmic Review

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Clinical Models and Algorithms for the Prediction of Retinopathy of Prematurity

Abstract: Additional research is needed to optimize ROP predictive model development, validation, and application before such models can be used widely to reduce the burdensome number of ROP screening examinations.

Cited by 48 publications

References 43 publications

Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis

Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis

Advances in understanding and management of retinopathy of prematurity

The Role of Anti-vascular Endothelial Growth Factor Agents in the Management of Retinopathy of Prematurity

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