Rising incidence of carbapenem resistant isolates: an Argentinian hospital’s experience. More trouble in the aftermath of the COVID-19 pandemic

This research, led by the IHCIT in collaboration with the ADAPTARC project of SERNA/UNDP, forms a crucial part of the author's doctoral and master's thesis. Focusing on the Rio Chiquito sub-basin in Tegucigalpa, the capital of Honduras, it aims to offer a preliminary insight into the dynamics of the isophreatic curves as a technical tool for decision-makers. Despite its relatively small size, this sub-basin features a dramatic elevation change, ranging from 950 - 2200 meters above sea level over a 21km river length and with 30% urbanization. The study involved meticulous information management of over 100 wells, primarily used for human consumption, highlighting the community's dependence on groundwater. Given the intermittent and insufficient municipal water supply, this was especially critical, emphasizing groundwater's role in meeting basic needs and public health. The findings reveal underground water levels varying between 5 to 20 meters on average, with peaks up to 60 meters in the subbasin's lower western area. This underground flow aligns with the sub-basin geomorphology and surface dynamics, showing a gradient from 950 to 1200 meters in the middle-lower part, ascending to 2200 meters in the middle-upper region. Keywords: water table, aquifer, groundwater, sub-basin,

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Post-Coronavirus Disease 2019 Pandemic Antimicrobial Resistance

Boccabella,

Palma,

Abenavoli

et al. 2024

Antibiotics

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Background and aim: Antimicrobial resistance (AMR) is a chronic issue of our Westernized society, mainly because of the uncontrolled and improper use of antimicrobials. The coronavirus disease 2019 (COVID-19) pandemic has triggered and expanded AMR diffusion all over the world, and its clinical and therapeutic features have changed. Thus, we aimed to review evidence from the literature on the definition and causative agents of AMR in the frame of the COVID-19 post-pandemic era. Methods: We conducted a search on PubMed and Medline for original articles, reviews, meta-analyses, and case series using the following keywords, their acronyms, and their associations: antibiotics, antimicrobial resistance, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), COVID-19 pandemic, personal protective equipment. Results: AMR had a significant rise in incidence both in in-hospital and outpatient populations (ranging from 5 up to 50%) worldwide, but with a variegated profile according to the germ and microorganism considered. Not only bacteria but also fungi have developed more frequent and diffuse AMR. These findings are explained by the increased use and misuse of antibiotics and preventive measures during the first waves of the SARS-CoV2 pandemic, especially in hospitalized patients. Subsequently, the reduction in and end of the lockdown and the use of personal protective equipment have allowed for the indiscriminate circulation of resistant microorganisms from low-income countries to the rest of the world with the emergence of new multi- and polyresistant organisms. However, there is not a clear association between COVID-19 and AMR changes in the post-pandemic period. Conclusions: AMR in some microorganisms has significantly increased and changed its characteristics during and after the end of the pandemic phase of COVID-19. An integrated supranational monitoring approach to this challenge is warranted in the years to come. In detail, a rational, personalized, and regulated use of antibiotics and antimicrobials is needed.

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Rising incidence of carbapenem resistant isolates: an Argentinian hospital’s experience. More trouble in the aftermath of the COVID-19 pandemic

Cited by 4 publications

References 34 publications

Antibiotic resistance associated with the COVID-19 pandemic: a systematic review and meta-analysis

Antibiotic resistance associated with the COVID-19 pandemic: a systematic review and meta-analysis

Dynamics of the Water Table in the Rio Chiquito Sub-basin, Honduras

Post-Coronavirus Disease 2019 Pandemic Antimicrobial Resistance

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