RIR-MAPLE deposition of multifunctional films combining biocidal and fouling release properties

Yu, Qian; Ge, Wangyao; Atewologun, Ayomide; López, Gabriel P.

doi:10.1039/c4tb00566j

Cited by 51 publications

(31 citation statements)

References 36 publications

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“…[94,130] When the system was additionally loaded with low molecular weight quaternary ammonium salts, the killing efficiency against E. coli and S. aureus was between 80-85%, and it released 65-80% of the attached bacteria. [131] Similar effects were obtained with release systems consisting of nano-patterned PNIPAM brushes and quaternary ammonium salts, [132] or PNIPAM with lysozyme. [133] While these materials are conceptually very interesting, the remaining question is how practical this temperature dependent property is for real-life applications.…”

Section: Regeneration Of Antimicrobial Activity Of Polymer Surfacessupporting

confidence: 54%

“…Below the LCST, the material was protein‐repellent and released up to 62% of attached dead bacteria . When the system was additionally loaded with low molecular weight quaternary ammonium salts, the killing efficiency against E. coli and S. aureus was between 80–85%, and it released 65–80% of the attached bacteria . Similar effects were obtained with release systems consisting of nano‐patterned PNIPAM brushes and quaternary ammonium salts, or PNIPAM with lysozyme .…”

Section: Regeneration Of Antimicrobial Activity Of Polymer Surfacessupporting

confidence: 53%

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Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Riga¹,

Vöhringer²,

Widyaya³

et al. 2017

Macromol. Rapid Commun.

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Contact-active antimicrobial polymer surfaces bear cationic charges and kill or deactivate bacteria by interaction with the negatively charged parts of their cell envelope (lipopolysaccharides, peptidoglycan, and membrane lipids). The exact mechanism of this interaction is still under debate. While cationic antimicrobial polymer surfaces can be very useful for short-term applications, they lose their activity once they are contaminated by a sufficiently thick layer of adhering biomolecules or bacterial cell debris. This layer shields incoming bacteria from the antimicrobially active cationic surface moieties. Besides discussing antimicrobial surfaces, this feature article focuses on recent strategies that were developed to overcome the contamination problem. This includes bifunctional materials with simultaneously presented antimicrobial and protein-repellent moieties; polymer surfaces that can be switched from an antimicrobial, cell-attractive to a cell-repellent state; polymer surfaces that can be regenerated by enzyme action; degradable antimicrobial polymers; and antimicrobial polymer surfaces with removable top layers.

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Section: Regeneration Of Antimicrobial Activity Of Polymer Surfacessupporting

confidence: 54%

Section: Regeneration Of Antimicrobial Activity Of Polymer Surfacessupporting

confidence: 53%

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Riga¹,

Vöhringer²,

Widyaya³

et al. 2017

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…Furthermore, the laser-based technologies are exhibiting a lot of advantages, as they allow for the fabrication of a wide-range of different biomaterials, with a fairly uniform spreading of material over rather large areas, controlled film thickness (with an accuracy of 1 Å), good adhesion to substrate (Blind et al, 2005;Duta et al, 2013;Mihailescu et al, 2016), and specific surface properties (Sima and Mihailescu, 2013). Moreover, these deposition methods imply a low material consumption, and ensure the stoichiometry preservation of the growing films (Eason, 2006;Yu et al, 2014;Cristescu et al, 2012). In the same time, remarkable efforts were recently paid to the development by combinatorial processing of new biomaterials with innovative properties.…”

Section: Introductionmentioning

confidence: 99%

Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders

Visan

Stan

Ristoscu

et al. 2016

International Journal of Pharmaceutics

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Chitosan/biomimetic apatite thin films were grown in mild conditions of temperature and pressure by Combinatorial Matrix-Assisted Pulsed Laser Evaporation on Ti, Si or glass substrates. Compositional gradients were obtained by simultaneous laser vaporization of the two distinct material targets. A KrF* excimer (λ=248nm, τFWHM=25ns) laser source was used in all experiments. The nature and surface composition of deposited materials and the spatial distribution of constituents were studied by SEM, EDS, AFM, GIXRD, FTIR, micro-Raman, and XPS. The antimicrobial efficiency of the chitosan/biomimetic apatite layers against Staphylococcus aureus and Escherichia coli strains was interrogated by viable cell count assay. The obtained thin films were XRD amorphous and exhibited a morphology characteristic to the laser deposited structures composed of nanometric round shaped grains. The surface roughness has progressively increased with chitosan concentration. FTIR, EDS and XPS analyses indicated that the composition of the BmAp-CHT C-MAPLE composite films gradually modified from pure apatite to chitosan. The bioevaluation tests indicated that S. aureus biofilm is more susceptible to the action of chitosan-rich areas of the films, whilst the E. coli biofilm proved more sensible to areas containing less chitosan. The best compromise should therefore go, in our opinion, to zones with intermediate-to-high chitosan concentration which can assure a large spectrum of antimicrobial protection concomitantly with a significant enhancement of osseointegration, favored by the presence of biomimetic hydroxyapatite.

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“…17 Emulsion-based RIR-MAPLE has already been applied to fabricate OSCs, 18,19 optical coatings, 20 and functional biosurfaces. 21,22 A schematic diagram of the emulsion-based RIR-MAPLE technique is shown in Figure 1. Compared to traditional MAPLE, emulsion-based RIR-MAPLE also combines aspects of PVD and solution-processing; yet, two important aspects of emulsion-based RIR-MAPLE stand in sharp contrast to traditional MAPLE.…”

Section: Introductionmentioning

confidence: 99%

Emulsion-Based RIR-MAPLE Deposition of Conjugated Polymers: Primary Solvent Effect and Its Implications on Organic Solar Cell Performance

McCormick

et al. 2016

ACS Appl. Mater. Interfaces

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Emulsion-based, resonant infrared matrix-assisted pulsed laser evaporation (RIR-MAPLE) has been demonstrated as an alternative technique to deposit conjugated polymer films for photovoltaic applications; yet, a fundamental understanding of how the emulsion target characteristics translate into film properties and solar cell performance is unclear. Such understanding is crucial to enable the rational improvement of organic solar cell (OSC) efficiency and to realize the expected advantages of emulsionbased RIR-MAPLE for OSC fabrication. In this paper, the effect of the primary solvent used in the emulsion target is studied, both experimentally and theoretically, and it is found to determine the conjugated polymer cluster size in the emulsion as well as surface roughness and internal morphology of resulting polymer films. By using a primary solvent with low solubility-in-water and low vapor pressure, the surface roughness of deposited P3HT and PCPDTBT polymer films was reduced to 10 nm, and the efficiency of P3HT:PC 61 BM OSCs was increased to 3.2% (∼100 times higher compared to the first MAPLE OSC demonstration [Caricato, A. P.; et al. Appl. Phys. Lett. 2012, 100, 073306]). This work unveils the mechanism of polymer film formation using emulsion-based RIR-MAPLE and provides insight and direction to determine the best ways to take advantage of the emulsion target approach to control film properties for different applications.

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RIR-MAPLE deposition of multifunctional films combining biocidal and fouling release properties

Abstract: Multifunctional films combining switchable biocidal and fouling release properties were deposited on substrates using RIR-MAPLE.

Cited by 51 publications

References 36 publications

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications

Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders

Emulsion-Based RIR-MAPLE Deposition of Conjugated Polymers: Primary Solvent Effect and Its Implications on Organic Solar Cell Performance

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