Riproximin is a recently discovered type II ribosome inactivating protein with potential for treating cancer

Adwan, Hassan; Bayer, Helene; Pervaiz, Asim; Sagini, Micah N.; Berger, Martin R.

doi:10.1016/j.biotechadv.2014.03.008

Cited by 23 publications

(10 citation statements)

References 37 publications

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“…This increases the expression of the UPR genes ATF6 and ERN1 . A higher concentration of RPX induces the UPR pathway via the EIF2AK3 branch, which results in numerous complex effects, such as translational arrest, growth inhibition, and apoptosis by enhanced EIF2A phosphorylation that includes elevated expression of transcription factors such as ATF3 and DDIT3 280 . The antioxidant 2-(3, 4-dihydroxyphenyl) ethanol (DPE) derived from olive oil induces growth arrest and apoptosis in HT-29 cells.…”

Section: Inhibitors and Activators Of Autophagy And The Upr In Crcmentioning

confidence: 99%

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

et al. 2017

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Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still remains a major life-threatening malignancy. CRC etiology entails both genetic and environmental factors. Macroautophagy/autophagy and the unfolded protein response (UPR) are fundamental mechanisms involved in the regulation of cellular responses to environmental and genetic stresses. Both pathways are interconnected and regulate cellular responses to apoptotic stimuli. In this review, we address the epidemiology and risk factors of CRC, including genetic mutations leading to the occurrence of the disease. Next, we discuss mutations of genes related to autophagy and the UPR in CRC. Then, we discuss how autophagy and the UPR are involved in the regulation of CRC and how they associate with obesity and inflammatory responses in CRC. Finally, we provide perspectives for the modulation of autophagy and the UPR as new therapeutic options for CRC treatment.

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Section: Inhibitors and Activators Of Autophagy And The Upr In Crcmentioning

confidence: 99%

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

et al. 2017

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“…All aforementioned studies indicate that the toxin has significant cytotoxicity and can be applied as an anticancer drug. Many anti-tumor studies of various RIPs were conducted by research-ers based on the MCF-7 cell line [19][20][21][22][23][24][25][26]. However, to the best of our knowledge, it is the first study that evaluates the toxicity of this toxin on MCF-7 cells.…”

Section: Discussionmentioning

confidence: 99%

Introduction of Dianthins: A New Promising Horizon Toward Continuous Research on Breast Cancer Bulldozing in Iran

Pour

Zargan

Hamed

et al. 2019

IJMTFM

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The production and secretion of defense proteins are one of the protective mechanisms exploited by plants against pathogens. The production and secretion of defense proteins are one of the protective mechanisms exploited by plants against pathogens. Ribosome-Inactivating Proteins (RIPs), as the main class of these proteins, are considered to facilitate cancer therapy worldwide, because of the potential anticancer activity. Indeed, some of these proteins have cytotoxic and anticancer properties. Extracted from the carnation (Dianthus caryophyllus), Dianthin inhibits protein synthesis in many different cells. Methods: In this research, the Dianthins was isolated and purified from the leaves of D. caryophyllus, using ion-exchange chromatography column (CM-Sephadex G-50). Subsequently, its cytotoxicity effect on MCF-7 cell line was investigated. The cell cytotoxicity assessment was performed, using 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT), neutral red uptake, and alkaline comet assays at the concentrations of 1.25μg/ mL to 10μg/mL of the protein applying the MCF-7 cell line. Results: the toxin induces cell death, mostly via necrosis rather than apoptosis, but in the special range of concentrations. Conclusion: because of the severe side effects of chemotherapy drugs, this toxin can undergo more research as a new drug candidate against breast cancer.

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“…As shown before, after intraportal injection, the ASML cells grew aggressively and consistently in the rat liver. To a certain extent, the resulting colonization simulates liver PDAC metastasis with regard to growth behavior and resistance towards chemotherapy [1,5,15,22]. …”

Section: Discussionmentioning

confidence: 99%

Metastasis-Related Processes Show Various Degrees of Activation in Different Stages of Pancreatic Cancer Rat Liver Metastasis

et al. 2014

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Background: Most pancreatic ductal adenocarcinoma (PDAC) patients who undergo tumor resection will develop postoperative liver metastasis within the first 2 years. Our hypothesis was that, during liver colonization, the temporal modulation of processes related to metastasis will change in a specific manner and that information on these changes might be used for new therapeutic approaches. Material and Methods: PDAC rat ASML cells were inoculated into the liver of BDX rats and re-isolated after different time periods of liver colonization (early, intermediate, advanced, and terminal). The total RNA of these samples was used to evaluate the expression profiles of more than 23,000 genes by chip array analysis. Results: Depending on the time span following re-isolation, 7-15% of all known genes were deregulated. These genes were assigned to metastasis-related processes during the 4 stages of colonization. Except for apoptosis, all other processes were not activated in the early and middle colonization stages. In the terminal phase of liver colonization, cell proliferation, cell homing, cell movement, and vasculogenesis were significantly activated. Conclusion: We hypothesize that targeting the relatively few deregulated genes in the early stage of liver colonization could ultimately improve the survival of PDAC patients.

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Riproximin is a recently discovered type II ribosome inactivating protein with potential for treating cancer

Cited by 23 publications

References 37 publications

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

Introduction of Dianthins: A New Promising Horizon Toward Continuous Research on Breast Cancer Bulldozing in Iran

Metastasis-Related Processes Show Various Degrees of Activation in Different Stages of Pancreatic Cancer Rat Liver Metastasis

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