Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents

Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring

“…With the same concept, a series of ring substituted (E)-3-Phenyl-1-(2 pyrazinyl)-2-propen-1-ones were screened for their efficacy against Mtb H37Rv. Among all, compound 19 showed an inhibition of 94% at 12.5 μg/mL [41]. While in a series of pyrazine derivatives, two compound (140a and 20b) have shown equal potency of MIC 6.25 μg/mL against Mtb H37Rv [42].…”

Synthesis and Evaluation of Pyrazine Derivatives with Herbicidal Activity

“…2-Hydroxy substituted derivatives were found to be more effective inhibitors of photosynthesis than the 4-hydroxy substituted ones. The inhibitory activity of 2-hydroxy substituted derivatives was affected also by the branching of R 1 substituent: OER inhibition in photosynthesizing organisms by the isomers with branched alkyl chain (tert-butyl, isobutyl) was more pronounced than by the isomer with unbranched alkyl substituent (n-butyl) (Opletalová et al, 2002 Opletalová et al, 2006 (k) , Chlupáčová et al, 2005 (l) ), ND -not determined.…”

“…Several series (thirty two compounds) of ring substituted (E)-3-phenyl-1-(pyrazin-2-yl)-prop-2-en-1-ones XX (Fig. 12) were prepared in our laboratories by means of modified Claisen-Schmidt condensation of acetylpyrazines with aromatic aldehydes (Opletalová et al, 2002, Opletalová et al, 2006, Chlupáčová et al, 2005. Ring substituted (E)-3-phenyl-1-(pyrazin-2-yl)-prop-2-en-1-ones XX were tested for their activity related to OER inhibition in spinach chloroplasts and Chlorella vulgaris as well as reduction of chlorophyll content in statically cultured suspensions of freshwater alga Chlorella vulgaris.…”

“…Ring substituted (E)-3-phenyl-1-(pyrazin-2-yl)-prop-2-en-1-ones XX were tested for their activity related to OER inhibition in spinach chloroplasts and Chlorella vulgaris as well as reduction of chlorophyll content in statically cultured suspensions of freshwater alga Chlorella vulgaris. Opletalová et al, 2002).…”

Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

“…Pyrazine and pyrazinamide analogs exhibited potent antibacterial activity, e.g. pyrazinoic acid esters 1 , pyrazine thiocarboxamide 2 and ring substituted pyrazinylchalcones 3 . Pyrazine carboxamide derivatives have been reported to possess diverse pharmacological activities including antimicrobial activity, fungicidal activity, herbicidal activity, anti-oxidant activity and antialgal activity [4][5][6][7][8][9][10][11] .…”