Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
Synthesis and Photosynthesis-Inhibiting Activity of Some Anilides of Substituted Pyrazine-2-carboxylic Acids.-Several novel hydroxyphenylamides of the title pyrazinecarboxylic acids (III) are synthesized by standard techniques. The ability of these compounds to inhibit photosynthesis in spinach chloroplasts is shown to increase with increasing lipophilicity. In general, the introduction of a chlorine substituent into the pyrazine ring increases the pharmacological activity. The best results are obtained for derivative (IIIb). -(DOLEZAL, M.; HARTL, J.; MILETIN, M.; MACHACEK, M.; KRALOVA, K.; Chem. Pap. 53 (1999) 2, 126-130; Fac. Pharm., Charles Univ., CZ-500 05 Hradec Kralove, Czech Republic; EN)
A group of 26 new 2-halogeno-6-alkylsulfanyl-and 2,6-bis-alkylsulfanyl-4-amidopyridines and corresponding thioamidopyridines was synthesised. Some of the amidopyridines and all thioamidopyridines were tested for their antimycobacterial activity against atypical mycobacterial strains. Promising photosynthesis-inhibiting activity was also found for some of the amidopyridines.
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