Ring 10 chromosome: 46,XX,r10(p15q26)

Sparkes, Robert S.; Ling, Shun M.; Müller, Herbert

doi:10.1007/bf00278844

Cited by 28 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In an earlier paper, we touched upon an interesting finding of an aggressive follicular thyroid carcinoma in a young girl with a constitutional ring chromosome, most likely lacking genetic material at the distal part of chromosome lOq (Sparkes et al 1978;Tommerup and Lothe 1992). In the present study, more than one-third of the tumors showed LOH at chromosome lOq (Fig 1).…”

Section: Discussionsupporting

confidence: 51%

Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors

et al. 1996

View full text Add to dashboard Cite

Previous studies of follicular thyroid tumors have shown loss of heterozygosity (LOH) on the short arm of chromosome 3 in carcinomas, and on chromosome 10 in atypical adenomas and carcinomas, but not in common adenomas. We studied LOH on these chromosomal arms in 15 follicular thyroid carcinomas, 19 atypical follicular adenomas and 6 anaplastic (undifferentiated) carcinomas. Deletion mapping of chromosome 10 using 15 polymorphic markers showed that 15 (37.5%) of the tumors displayed LOH somewhere along the long arm. Thirteen of these tumors showed deletions involving the telomeric part of chromosome lOq, distal to D10S187. LOH on chromosome 3p was found in 8 (20%) cases. Seven of these also showed LOH on chromosome lOq. In eight cases LOH was seen on chromosome lOq but not 3p. In comparison, the retinoblastoma gene locus at chromosome 13q showed LOH in 22% of the tumors. Most of these also had deletions on chromosome lOq. The results indicate that a region at the telomeric part of 1 Oq may be involved in progression of follicular thyroid tumors.

show abstract

Section: Discussionsupporting

confidence: 51%

Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Four cases of ring chromosome 10 [present case; Simoni et al, 1979;Sparkes et al, 1978;Tsukino et al, 19801 had breakpoints assigned at p15;q26. The degree of mosaicism was quite similar, and 46 chromosomes were found in 84-96% of cells in these four patients ( Table I).…”

Section: Discuss1 Onmentioning

confidence: 95%

“…Ring chromosome 10 has been reported previously in five patients whose chromosomes were studied using banding methods [Fryns et al, 1978;Lansky et al, 1977;Simoni et al, 1979;Sparkes et al, 1978;Tsukino et al, 19801. Four of these patients had a ring 10 chromosome as their only abnormality, but one also had a t(lOq;l9p) [Fryns et al, 19781.…”

Section: Introductionmentioning

confidence: 95%

Phenotype associated with ring 10 chromosome: Report of patient and review of literature

Michels¹,

Driscoll²,

Ledbetter³

et al. 1981

Am. J. Med. Genet.

View full text Add to dashboard Cite

A 15-month-old infant's peripheral blood chromosome analysis showed the following defects: 46,XY,r(10)(p15.3q26.1) in 84 cells, 45,XY,-r(10) in 13 cells, and 47,XY,r(10),+r(10) in one cell. Clinical abnormalities included growth retardation, microcephaly, prominent nasal bridge, macular hypoplasia, persistent pulmonary hypertension, and posterior urethral valves with hydronephrosis. Comparison of the phenotype of five other patients with a ring chromosome 10 with the present case showed the following common manifestations: growth retardation, microcephaly, undescended testes, hydronephrosis, and, in males, posterior urethral valves. To date, this last anomaly has not been seen in patients with either a del(10p) or a del(10q) abnormality.

show abstract

“…Only nine patients with a ring chromosome 10 have so far been reported (Lansky et al, 1977;Fryns et al, 1978;Sparkes et al, 1978;Simoni et al, 1979;Tsukino et al, 1980;Michels et al, 1981, Serville et al, 1982Nakai et al, 1983;Kondo et al, 1984). In this report, we present a patient with a mosaic karyotype of 45,XY, -10/46,XY/46,XY,r(10) (pl 5.3@6.3) who showed relatively mild phenotypic anomalies.…”

Section: Introductionmentioning

confidence: 67%

Report of a patient with a ring chromosome 10: mos45,XY,−10/46,XY/46,XY,r(10) (p15.3q26.3)

et al. 1985

View full text Add to dashboard Cite

SummaryA 2.5-year-old boy with a ring chromosome 10 was described. Clinical features included developmental retardation, short stature, mild mental retardation and cryptorchidism. He had a history of photohypersensitivity. By using PHA stimulated peripheral blood lymphocytes, Epstein-Barr virus transformed lymphoblastoid cell line and cultured skin fibroblasts, his karyotype was identified to be mos45,XY,-10/46,XY/ 46,XY,r(10) (pl 5.3q26.3). INTRODUCTIONOnly nine patients with a ring chromosome 10 have so far been reported (Lansky et al., 1977;Fryns et al., 1978;Sparkes et al., 1978;Simoni et al., 1979;Tsukino et al., 1980;Michels et al., 1981, Serville et al., 1982Nakai et al., 1983;Kondo et al., 1984). In this report, we present a patient with a mosaic karyotype of 45,XY, -10/46,XY/46,XY,r(10) (pl 5.3@6.3) who showed relatively mild phenotypic anomalies. The ring chromosome was analyzed in more detail by high-resolution banding. CASE REPORTThe proband was the first child of non-consanguineous parents. He was born after an uncomplicated pregnancy of 39 weeks and a normal delivery. There was

show abstract

Ring 10 chromosome: 46,XX,r10(p15q26)

Cited by 28 publications

References 13 publications

Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors

Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors

Phenotype associated with ring 10 chromosome: Report of patient and review of literature

Report of a patient with a ring chromosome 10: mos45,XY,−10/46,XY/46,XY,r(10) (p15.3q26.3)

Contact Info

Product

Resources

About