Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors

Abstract

Previous studies of follicular thyroid tumors have shown loss of heterozygosity (LOH) on the short arm of chromosome 3 in carcinomas, and on chromosome 10 in atypical adenomas and carcinomas, but not in common adenomas. We studied LOH on these chromosomal arms in 15 follicular thyroid carcinomas, 19 atypical follicular adenomas and 6 anaplastic (undifferentiated) carcinomas. Deletion mapping of chromosome 10 using 15 polymorphic markers showed that 15 (37.5%) of the tumors displayed LOH somewhere along the long arm. Thirteen of these tumors showed deletions involving the telomeric part of chromosome lOq, distal to D10S187. LOH on chromosome 3p was found in 8 (20%) cases. Seven of these also showed LOH on chromosome lOq. In eight cases LOH was seen on chromosome lOq but not 3p. In comparison, the retinoblastoma gene locus at chromosome 13q showed LOH in 22% of the tumors. Most of these also had deletions on chromosome lOq. The results indicate that a region at the telomeric part of 1 Oq may be involved in progression of follicular thyroid tumors.

The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive

“…Moreover, loss of heterozygosity on chromosome 10q22 has been observed in two follicular carcinomas adjacent to an area of anaplastic carcinomas (29,30). These data would support the involvement of other suppressor genes in the progression process leading to the anaplastic phenotype.…”

PTEN/MMAC1 Mutation and Frequent Loss of Heterozygosity Identified in Chromosome 10q in a Subset of Hepatocellular Carcinomas

“…Recent studies have shown that the distal region of chromosome 10q is commonly deleted in glioma, lung cancer, melanoma, prostate cancer, bladder cancer, and thyroid tumor. 12,15,16,20,37) These results indicate that there are putative tumor suppressor gene(s) on the distal region of 10q, which are involved in various types of carcinomas.…”

Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma

“…Clearly, the existence of such candidate genes, which are lost in the samples studied here, remains to be determined. Analysis of LOH in a variety of tumours has suggested that multiple discrete regions of chromosome 10 loss may occur in a single tumour or tumour type (Parmiter et al, 1988;Karlbom et al, 1993;Herbst et al, 1994;Peiffer et al, 1995;Albarosa et al, 1996;Ittmann, 1996;Trybus et al, 1996;Zedenius et al, 1996;Marsh et al 1998b). The precise physical localization of such deleted regions with respect to one another and the number of tumoursuppressor genes they represent has been difficult to determine, in part because of the variety of markers used in the different studies.…”