Rightward cerebral asymmetry in subtypes of schizophrenia according to Leonhard's classification and to DSM-IV: a structural MRI study

Sallet, Paulo Clemente; Elkis, Hélio; Alves, Tânia Maria; Oliveira, José Renato Silva de; Sassi, Erlei; Castro, Cláudio Campi de; Busatto, Geraldo F.; Gattaz, Wagner F.

doi:10.1016/s0925-4927(03)00020-9

Cited by 24 publications

(19 citation statements)

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“…Abnormalities in cerebral lateralization were thought to reflect early neurodevelopmental defects in schizophrenia [51]. Our findings were consistent partly with the few previous studies; the negative symptom in schizophrenia was reported to be associated with the lateralization of brain structure and function [67], [68].…”

Section: Discussionsupporting

confidence: 92%

Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia

et al. 2012

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IntroductionCurrent pathophysiological theories of schizophrenia highlight the role of altered brain functional and anatomical connectivity. The cognitive division of anterior cingulate cortex (ACC-cd) is a commonly reported abnormal brain region in schizophrenia for its importance in cognitive control process. The aim of this study was to investigate the functional and anatomical connectivity of ACC-cd and its cognitive and clinical manifestation significance in schizophrenia by using the resting-state functional magnetic resonance imaging (fMRI) and the diffusion tensor imaging (DTI).MethodsThirty-three medicated schizophrenics and 30 well-matched health controls were recruited. Region-of-interest (ROI)-based resting-state functional connectivity analysis and Tract-Based Spatial Statistics (TBSS) were performed on 30 patients and 30 controls, and 24 patients and 29 controls, respectively. The Pearson correlation was performed between the imaging measures and the Stroop performance and scores of the Positive and Negative Syndrome Scale (PANSS), respectively.ResultsPatients with schizophrenia showed significantly abnormal in the functional connectivity and its hemispheric asymmetry of the ACC-cd with multiple brain areas, e.g., decreased positive connectivity with the bilateral putamen and caudate, increased negative connectivity with the left posterior cingulated cortex (PCC), increased asymmetry of connectivity strength with the contralateral inferior frontal gyrus (IFG). The FA of the right anterior cingulum was significantly decreased in patients group (p = 0.014). The abnormal functional and structural connectivity of ACC-cd were correlated with Stroop performance and the severity of the symptoms in patients.ConclusionsOur results suggested that the abnormal connectivity of the ACC-cd might play a role in the cognitive impairment and clinical symptoms in schizophrenia.

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Section: Discussionsupporting

confidence: 92%

Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia

et al. 2012

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“…Thus, to simultaneously investigate the complex inter face between the factors "illness phase" (first episode vs. Baiano et al, 2008Breier et al, 1992Chakos et al, 2005c Fukuzako et al, 1996Fukuzako et al, 1997Kuroki et al, 2006Marsh et al, 1997Meisenzahl et al, 2009c Rametti et al, 2007Razi et al, 1999c Sachdev et al, 2000Sallet et al, 2003Sanfilipo et al, 2000Sim et al, 2006Spoletini et al, 2011c Swayze et al, 1992Velakoulis et al, 1999c Weiss et al, 2005Whitworth et al, 1998c Whitworth et al, 2005c Wood et al, 2001c Zipursky et al, 1994 Total (95% CI) Heterogeneity: Tau² = 0.65; Chi² = 229.32, df = 21 (P < 0.00001); I² = 91% Test for overall effect: Z = 3.17 (P = 0.002) The Neuroscientist 18(2) chronic) and "side" (left hippocampus vs. right hippo campus), we performed (on the sample of studies that included the illness phase variable) a twoway ANOVA on the effect size of the hippocampal volume change. This twoway analysis indicated no significant effect of the illness phase factor (F = 0.026; df = 1, 66; P = .8718), no significant effect of the side factor (F = 0.019; df = 1, 66; P = .8911), and no significant effect of the interac tion between these two factors (F = 0.178; df = 1, 66; P = .6744).…”

Section: "Illness Phase" By "Side" Anovasmentioning

confidence: 99%

“…The Neuroscientist 18 (2) Study or Subgroup Altshuler et al, 1998Baiano et al, 2008Becker et al, 1990Breier et al, 1992Chakos et al, 2005Chakos et al, 2005c Ebdrup et al, 2010Exner et al, 2008Frazier et al, 2008Fukuzako et al, 1996Fukuzako et al, 1997Gur et al, 2000Kuroki et al, 2006Levitt et al, 2001Marsh et al, 1997Matsumoto et al, 2001Meisenzahl et al, 2009Meisenzahl et al, 2009c Niemann et al, 2000Rajarethinam et al, 2001Rametti et al, 2007Razi et al, 1999Razi et al, 1999c Rupp et al, 2005Rusch et al, 2008Sachdev et al, 2000Sallet et al, 2003Sanfilipo et al, 2000Sim et al, 2006Smith et al, 2003Spoletini et al, 2011c Strasser et al, 2005Sumich et al, 2002 Suzuki et al, 2005 (b) Swayze et al, 1992Szendi et al, 2006Szeszko et al, 2003Takahashi et al, 2006Tanskanen et al, 2005Velakoulis et al, 1999Velakoulis et al, 1999c Verma et al, 2009Weiss et al, 2005…”

mentioning

confidence: 99%

“…The Neuroscientist 18(2) Study or Subgroup Chakos et al, 2005Ebdrup et al, 2010Meisenzahl et al, 2009Niemann et al, 2000Razi et al, 1999Smith et al, 2003Sumich et al, 2002Szeszko et al, 2003Velakoulis et al, 1999Verma et al, 2009Whitworth et al, 1998Whitworth et al, 2005Wood et al, 2001 Total (95% CI) Heterogeneity: Tau² = 0.09; Chi² = 27.24, df = 12 (P = 0.007); I² = 56% Test for overall effect: Z = 5.29 (P < 0.00001) Baiano et al, 2008Breier et al, 1992Chakos et al, 2005c Fukuzako et al, 1996Fukuzako et al, 1997Kuroki et al, 2006Marsh et al, 1997Meisenzahl et al, 2009c Rametti et al, 2007Razi et al, 1999c Sachdev et al, 2000Sallet et al, 2003Sanfilipo et al, 2000Sim et al, 2006Spoletini et al, 2011c Swayze et al, 1992Velakoulis et al, 1999c Weiss et al, 2005Whitworth et al, 1998c Whitworth et al, 2005c Wood et al, 2001c Zipursky et al, 1994 Total (95% CI) Heterogeneity: Tau² = 0.21; Chi² = 90.26, df = 21 (P < 0.00001); I² = 77% Test for overall effect: Z = 5.72 (P < 0.00001) with schizophrenia, and surpassed the medium level. The test for overall effect was significant (P = .002).…”

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confidence: 99%

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Hippocampal Volume Reduction in First-Episode and Chronic Schizophrenia

2011

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Several magnetic resonance imaging studies have reported hippocampal volume reduction in patients with schizophrenia, but other studies have reported contrasting results. In this review and meta-analysis, the authors aim to clarify whether a reduction in hippocampal volume characterizes patients with schizophrenia by considering illness phase (chronic and first episode) and hippocampus side separately. They made a detailed literature search for studies reporting physical volumetric hippocampal measures of patients with schizophrenia and healthy control (HC) participants and found 44 studies that were eligible for meta-analysis. Individual meta-analyses were also performed on 13 studies of first-episode patients and on 22 studies of chronic patients. The authors also detected any different findings when only males or both males and females were considered. Finally, additional meta-analyses and analyses of variance investigated the role of the factors "illness phase" and "side" on hippocampal volume reduction. Overall, the patient group showed significant bilateral hippocampal volume reduction compared with HC. Interestingly, first-episode and chronic patients showed same-size hippocampal volume reduction. Moreover, the left hippocampus was smaller than the right hippocampus in patients and HC. This review and meta-analysis raises the question about whether hippocampal volume reduction in schizophrenia is of neurodevelopmental origin. Future studies should specifically investigate this issue.

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“…phrenia in terms of a medical diagnosis with a unique etiopathogenesis [2,5,6] . Therefore, there is an urgent need for matching the typical psychotic phenomena to brain functions and vice versa in order to bridge the gap between clinical symptoms and their possible pathophysiology at the level of brain systems.…”

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confidence: 99%

The Bern Psychopathology Scale for the Assessment of System-Specific Psychotic Symptoms

et al. 2010

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The translation from psychiatric core symptoms to brain functions and vice versa is a largely unresolved issue. In particular, the search for disorders of single brain regions explaining classical symptoms has not yielded the expected results. Based on the assumption that the psychopathology of psychosis is related to a functional imbalance of higher-order brain systems, the authors focused on three specific candidate brain circuitries, namely the language, and limbic and motor systems. These domains are of particular interest for understanding the disastrous communication breakdown during psychotic disorders. Core symptoms of psychosis were mapped on these domains by shaping their definitions in order to match the related brain functions. The resulting psychopathological assessment scale was tested for interrater reliability and internal consistency in a group of 168 psychotic patients. The items of the scale were reliable and a principal component analysis (PCA) was best explained by a solution resembling the three candidate systems. Based on the results, the scale was optimized as an instrument to identify patient subgroups characterized by a prevailing dysfunction of one or more of these systems. In conclusion, the scale is apt to distinguish symptom domains related to the activity of defined brain systems. PCA showed a certain degree of independence of the system-specific symptom clusters within the patient group, indicating relative subgroups of psychosis. The scale is understood as a research instrument to investigate psychoses based on a system-oriented approach. Possible immediate advantages in the clinical application of the understanding of psychoses related to system-specific symptom domains are also discussed.

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Rightward cerebral asymmetry in subtypes of schizophrenia according to Leonhard's classification and to DSM-IV: a structural MRI study

Cited by 24 publications

References 53 publications

Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia

Functional and Anatomical Connectivity Abnormalities in Cognitive Division of Anterior Cingulate Cortex in Schizophrenia

Hippocampal Volume Reduction in First-Episode and Chronic Schizophrenia

The Bern Psychopathology Scale for the Assessment of System-Specific Psychotic Symptoms

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