Right ventricular failure due to primary right ventricle osteosarcoma

Sogabe, Osanori; Ohya, Takashi

doi:10.1007/s11748-006-0053-y

Cited by 12 publications

(3 citation statements)

References 6 publications

(4 reference statements)

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“…In addition to soft tissue sarcomas, bone sarcomas can also arise in heart [27–30]. In this series, we reported 1 dedifferentiated chondrosarcoma and 1 osteosarcoma of the heart.…”

Section: Discussionmentioning

confidence: 80%

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival

Zhang¹,

Brooks²,

Goldblum³

et al. 2008

Human Pathology

115

100

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Summary Although cardiac sarcomas are rare in comparison to their soft tissue counterparts, they are the second most common type of primary cardiac neoplasm. Of the few hundred cases reported, most has been based on autopsy series. A series of 27 cardiac sarcomas removed at surgery for curative and diagnostic intent were reviewed for clinicopathologic features with correlation to available postoperative follow-up data in 17 patients. There were 6 angiosarcomas, 6 myxofibrosarcomas, 3 malignant peripheral nerve sheath tumors, 3 leiomyosarcomas, 2 synovial sarcomas, 1 epithelioid hemangioendothelioma, 1 chondrosarcoma, 1 osteosarcoma, and 4 poorly differentiated sarcomas. There was a wide age and size range with slight female predilection. There were 20 cases that arose in the atria/pulmonary vessels, 4 in the ventricles, 1 in mitral valve, and 2 in epi/pericardium. There was a slight left predilection. The histologic grade was low in 4, moderate in 3, and high in 20 cases. Six high-grade and 1 low-grade tumors were also treated with adjuvant chemotherapy and/or radiation. In 17 patients with follow-up data, 6 of 12 patients with high-grade tumor died (4 within 5 days of the initial surgery, 1 in 21 months, and 1 in 131 months), and 1 patient with moderate-grade tumor and all 4 patients with low-grade tumor were alive without evidence of disease at the end of follow-up. Tumor grade appeared to be prognostically important in cardiac sarcoma. Long survival was achieved in patients who survived the initial surgery well.

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“…In addition to soft tissue sarcomas, bone sarcomas can also arise in heart [27–30]. In this series, we reported 1 dedifferentiated chondrosarcoma and 1 osteosarcoma of the heart.…”

Section: Discussionmentioning

confidence: 80%

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival

Zhang¹,

Brooks²,

Goldblum³

et al. 2008

Human Pathology

115

100

View full text Add to dashboard Cite

show abstract

“…Primary cardiac tumours leading to pulmonary tumour emboli include atrial myxoma [13], papillary fibroelastoma [14], lipoma [15], rhabdomyosarcoma [16], osteosarcoma [17], liposarcoma [18] and lymphoma [19]. Primary pulmonary artery undifferentiated sarcoma can present as chronic thromboembolic disease [20].…”

Section: Discussionmentioning

confidence: 99%

A 29-year-old male with chest pain and haemoptysis

Young¹,

Mills²,

Henriksen³

et al. 2008

European Respiratory Journal

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A 29-yr-old African male was admitted with a 1-week history of chest pain, shortness of breath and haemoptysis. He had returned from Africa by plane 2 weeks previously. The patient denied fever, sweats or weight loss. He had no significant past medical history, was not taking any regular medication, and was a lifelong nonsmoker. He lived in the UK and was in full-time education. with a predominance of neutrophils. Chest radiograph was normal. Computed tomography (CT) pulmonary angiography confirmed the presence of filling defects within branches of the right lower lobe, left lingular and left lower lobe pulmonary arteries, with no radiological evidence of right heart strain. Small nodules of f7 mm were identified in both lungs ( fig. 1). Several small mediastinal nodes were also identified. The patient was anti-coagulated with warfarin for bilateral pulmonary thromboembolism.The patient had further episodes of atypical chest pain and haemoptysis over the following month. He was readmitted with signs of right heart failure and normocytic anaemia. A repeat chest radiograph showed a globular heart with small bilateral pleural effusions.

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“…The tumor cells were strongly stained with antibodies to the osteoclast marker CD68 and vimentin, but were weakly stained with antibodies to CK, EMA, S-100, and CD34 (Figure 1). Based on these histological and immunohistochemical findings, the final diagnosis was primary cardiac osteosarcoma [1,2]. At present, 2 years after surgical removal of the tumor, the patient remains healthy with no evidence of tumor recurrence.…”

Section: Case Reportmentioning

confidence: 99%

Primary cardiac osteosarcoma in a 42-year-old woman

Lei

et al. 2010

J Cardiothorac Surg

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We describe here a 42-year-old woman who was admitted to hospital with a pedunculated mass in her left atrium. She was diagnosed with a primary cardiac osteosarcoma with special immunohistochemical characteristics. Echocardiography and computed tomography can be used to differentiate cardiac osteosarcomas from routine intracardiac tumors. The patient was treated by surgical removal of the mass. Two years later, she has shown no evidence of disease recurrence. We discuss primary osteosarcomas in the cardiac cavity and their management.

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Right ventricular failure due to primary right ventricle osteosarcoma

Cited by 12 publications

References 6 publications

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival

A 29-year-old male with chest pain and haemoptysis

Primary cardiac osteosarcoma in a 42-year-old woman

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