Primary cardiac osteosarcoma in a 42-year-old woman

Hy, Luo; Lei, Yiyan; Su, Chunhua; Li-hui, Cai; Zou, Jianyong; Chen, Zhenguang

doi:10.1186/1749-8090-5-120

Cited by 7 publications

(4 citation statements)

References 6 publications

(8 reference statements)

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“…Undifferentiated pleomorphic sarcoma is extremely rare. Most have been published as single case reports [6] and minimal epidemiological data have been collected. Usually, they present in young patients and have a poor prognosis, often fatal, considerably worse than that of extracardiac sarcomas.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence in autopsy series ranged from 0.001 to 0.3 % [5]. About threequarters of these are benign, the other quarter malignant [6].…”

mentioning

confidence: 99%

“…The incidence in autopsy series ranged from 0.001 to 0.3 % [5]. About threequarters of these are benign, the other quarter malignant [6]. Because of the few reported cases and poor prognosis of primary cardiac sarcomas, the metastatic potential and behaviour of these tumours are not fully understood [4].…”

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confidence: 99%

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Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

et al. 2015

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Dear Editor, Primary cardiac tumours are uncommon [3]. The incidence in autopsy series ranged from 0.001 to 0.3 % [5]. About threequarters of these are benign, the other quarter malignant [6]. Because of the few reported cases and poor prognosis of primary cardiac sarcomas, the metastatic potential and behaviour of these tumours are not fully understood [4].We present the case of a 28-year-old male who came acutely to our hospital because of congestive heart failure. He required an emergent thoracotomy to resection of a left atrium mass. The surgical excision was complete. The histological examination showed a diffusely infiltrating mass compatible with a pleomorphic high-grade sarcoma. After heart surgery the patient had chemotherapy and local radiation. One year later he was admitted to the neurosurgical department because of a 10-day history of headache, vomiting and instability. The cranial magnetic resonance imaging revealed a right cerebellar mass with ring contrast-enhancing and surrounding edema that compressed the fourth ventricle. The patient underwent an infratentorial craniectomy with complete resection of the lesion. Histopathologically the tumour was mainly composed of pleomorphic malignant cells with irregular nuclei and prominent nucleoli, areas of necrosis and a significant degree of anaplasia. Tumour cells were inmunoreative for vimentin, desmin, smooth muscle actin and neuronal specific enolase and negative for myo D1, CD99, CD68 and AE1/AE3. It was compatible with a metastasis of pleomorphic undifferentiated sarcoma with a positive muscle marker, suggesting leiomyosarcoma differentiation. The proliferation marker Ki67 was 60 %. The patient had subsequent chemotherapy and radiotherapy. Four years after complaining of left hip pain, the patient underwent hip magnetic resonance imaging, which revealed a well-demarcated mass at the left femoral neck, with heterogeneous gadolinium enhancement. There were no other bone, cardiac or brain lesions in the total body scan. He received palliative radiotherapy for the initial management of pain. Then a left proximal femoral resection and total hip replacement were performed. The histological analysis confirmed an osteolytic lesion composed of atypical giant undifferentiated cells compatible with a metastasis from cardiac pleomorphic sarcoma. More than 6 years after the initial diagnosis, the patient remains alive and healthy. DiscussionPrimary cardiac tumours represent between 5 % and 10 % of all cardiac tumours. The majority are benign, with only a small portion being malignant. Undifferentiated pleomorphic sarcoma is extremely rare. Most have been published as single case reports [6] and minimal epidemiological data have been collected. Usually, they present in young patients and have a poor prognosis, often fatal, considerably worse than that of * Aida Antuña Ramos

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Section: Discussionmentioning

confidence: 99%

“…The incidence in autopsy series ranged from 0.001 to 0.3 % [5]. About threequarters of these are benign, the other quarter malignant [6].…”

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confidence: 99%

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Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

et al. 2015

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“…The difference is that in our case, the two tumors in the cardiac cavity are anatomically independent of each other, indicating the double primary malignancies. The similar clinical symptoms and anatomic location lead to the confusion between primary cardiac osteosarcoma and atrial myxoma; however, some characteristics are helpful to distinguish them [11,12], such as myxomas tend to have a short and extensive base attached to adjacent sites, pedicled, soft, and often have some hemorrhagic and necrotic areas. Osteosarcoma generally originates from the non-septal atrial wall and often predisposes to invading the pulmonary vein.…”

Section: Discussionmentioning

confidence: 99%

A Primary Cardiac Osteosarcoma: Case Report and Literature Review

Zou

Chang

Gao

2021

Preprint

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Background: Primary cardiac osteosarcoma is an uncommon condition, which is challenging to diagnose, and rarely reported.Case presentation: Here, we present a previously healthy 27-year-old patient referred to our hospital with a long-term fever. Echocardiography and thoracic computed tomography (CT) presented two masses in the left atrium (LA) and left ventricle (LV), and surgical excision of the masses revealed cardiac high-grade osteosarcoma. Unfortunately, the left ventricular tumor recurred three months later, and the patient was administered periodic chemotherapy. Then, chest CT showed that the left ventricle was almost occupied by the tumor and also involved the left ventricular outflow tract, the left atrial appendage mass increased significantly, and multiple metastatic small nodules appeared in both lungs.The patient is still in follow-up.Conclusions: The prevalence of primary cardiac osteosarcoma is very low and did not involve LA and LV simultaneously. This patient was hospitalized in our hospital complaining of a long-term fever of unknown origin, which has never been reported in the previous literatures. Our case report findings suggest that primary cardiac osteosarcoma should not be ignored in the differential diagnosis of fever of unknown origin.

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Recurrent primary cardiac osteosarcoma: a case report and literature review

Dell’Amore

Asadi

Caroli

et al. 2013

Gen Thorac Cardiovasc Surg

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Primary malignant cardiac tumors are very rare. Among malignant tumors, sarcomas occupy first place. In particular, primary cardiac osteosarcoma is extremely rare. To the best of our knowledge, only 42 cases have been reported worldwide. Cardiac malignant tumors usually require complex operations due to the difficulty in completely removing the tumor with acceptable free surgical margins and because of the proximity to vital structures. The current multimodality treatment strategies for cardiac sarcoma are still suboptimal, and surgery in particular frequently has unsatisfactory results. We report a case of recurrent primary cardiac osteosarcoma in a young male who underwent trans-sternal right pneumonectomy and a wide resection of the left and right atrium followed by reconstruction with heterologous pericardium under extracorporeal circulation. The patient died 6 months after the operation due to local and systemic disease recurrence.

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Primary cardiac osteosarcoma in a 42-year-old woman

Cited by 7 publications

References 6 publications

Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

Cerebellar and bone metastasis from primary cardiac sarcoma: an unusual case

A Primary Cardiac Osteosarcoma: Case Report and Literature Review

Recurrent primary cardiac osteosarcoma: a case report and literature review

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