Right Heart Failure in Pulmonary Hypertension

Cassady, S.J.; Ramani, Gautam

doi:10.1016/j.ccl.2020.02.001

Cited by 54 publications

(47 citation statements)

References 77 publications

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“…It is recognized that the change of RV structure is the main predictor of poor clinical outcomes in PAH (22). There was no more than 18% of IPAH patients presented with ARHR after a mean of 20 ± 12 months in our study, despite that more than 93% of patients had received PAH-specific therapies.…”

Section: Discussioncontrasting

confidence: 51%

“…The RHRR might serve as a tool for pending prognosis in patients with IPAH. RA area, RVMD, and LV-EId selected in this study were conventional and important echocardiography indices (12,17,(21)(22)(23)(24). For example, RA area >18 cm 2 was considered as one of the preferred parameters for end-diastole RA enlargement (17).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, our findings supposed the change of RA area was also a marker of RA dilatation. If there is RV dilatation, RVMD should be measured to respond the chronic volume and/or pressure overload (22). In our study, RV size was measured from a four-chamber view, where RVMD was easily obtained and markers of RV dilatation.…”

Section: Discussionmentioning

confidence: 99%

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Echocardiographic Prognosis Relevance of Attenuated Right Heart Remodeling in Idiopathic Pulmonary Arterial Hypertension

Zhao

Gong

Jiang

et al. 2021

Front. Cardiovasc. Med.

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Background: Right ventricular (RV) function is a great determination of the fate in patients with pulmonary arterial hypertension (PAH). Monitoring RV structure back to normal or improvement should be useful for evaluation of RV function. The aims of this study were to assess the prognostic relevance of changed right heart (RH) dimensions by echocardiography and attenuated RH remodeling (ARHR) in idiopathic PAH (IPAH).Methods: We retrospectively analyzed 232 consecutive adult IPAH patients at baseline assessment and included RH catheterization and echocardiography. ARHR at the mean 20 ± 12 months' follow-up was defined by a decreased right atrium area, RV mid-diameter, and left ventricular end-diastolic eccentricity index. The follow-up end point was all-cause mortality.Results: At mean 20 ± 12 months' follow-up, 33 of 232 patients (14.2%) presented with ARHR. The remaining 199 surviving patients were monitored for another 25 ± 20 months. At the end of follow-up, the survival rates at 1, 3, and 5 years were 89, 89, and 68% in patients with ARHR, respectively, and 84, 65 and 41% in patients without ARHR (log-rank p = 0.01). ARHR was an independent prognostic factor for mortality. Besides, ARHR was available to further stratify patients' risk assessment through the French PAH non-invasive-risk criteria.Conclusions: Echocardiographic ARHR is an independent determinant of prognosis in IPAH at long-term follow-up. ARHR might be a useful tool to indicate the RV morphologic and functional improvement associated with better prognostic likelihood.

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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Echocardiographic Prognosis Relevance of Attenuated Right Heart Remodeling in Idiopathic Pulmonary Arterial Hypertension

Zhao

Gong

Jiang

et al. 2021

Front. Cardiovasc. Med.

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“…PH are nonspecific and asymptomatic in the early stage. As the disease progresses, the disease symptoms include dyspnea, fatigue, decreased exercise tolerance, syncope, angina pectoris, chest pain and right heart failure ( Cassady and Ramani, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

RNA Methylations in Cardiovascular Diseases, Molecular Structure, Biological Functions and Regulatory Roles in Cardiovascular Diseases

et al. 2021

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Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the world. Despite considerable progress in the diagnosis, treatment and prognosis of CVDs, new diagnostic biomarkers and new therapeutic measures are urgently needed to reduce the mortality of CVDs and improve the therapeutic effect. RNA methylations regulate almost all aspects of RNA processing, such as RNA nuclear export, translation, splicing and non-coding RNA processing. In view of the importance of RNA methylations in the pathogenesis of diseases, this work reviews the molecular structures, biological functions of five kinds of RNA methylations (m6A, m5C, m1a, m6am and m7G) and their effects on CVDs, including pulmonary hypertension, hypertension, vascular calcification, cardiac hypertrophy, heart failure. In CVDs, m6A “writers” catalyze the installation of m6A on RNAs, while “erasers” remove these modifications. Finally, the “readers” of m6A further influence the mRNA splicing, nuclear export, translation and degradation. M5C, m1A, m6Am and m7G are new types of RNA methylations, their roles in CVDs need to be further explored. RNA methylations have become a new research hotspot and the roles in CVDs is gradually emerging, the review of the molecular characteristics, biological functions and effects of RNA methylation on CVDs will contribute to the elucidation of the pathological mechanisms of CVDs and the discovery of new diagnostic markers and therapeutic targets of CVDs.

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“…1 Especially acute-onchronic s-RVF has a tremendously high mortality rate with up to 40%. 2 Mechanical circulatory support of the RV may be the only therapeutic strategy facing this rapidly progressive syndrome and was reported to be successful with various percutaneous cannulation techniques in cases of RVF due to myocardial infarction, after left ventricular assist device implantation and prior lung transplantation. 3,4 Herewith, we describe our experience with a percutaneously implanted right ventricular assist device (RVAD) combined with a regular veno-arterial extracorporeal membrane oxygenation (ECMO) set-up in a patient with acute s-RVF due to PAH under on-going resuscitation.…”

Section: Introductionmentioning

confidence: 99%

Dual-outflow extracorporeal membrane oxygenation support in secondary right ventricular failure

Hecker

Keller

Ischewski

et al. 2021

Preprint

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Acute-on-chronic right ventricular failure has a tremendously high mortality rate and pulmonary artery hypertension plays a major role in the progression of secondary right ventricular failure. Here, we report a case of drug-refractory acute-on-chronic right ventricular failure due to primary artery hypertension and a two-step approach of a percutaneous dual-outflow extracorporeal membrane oxygenation support set-up implanted under on-going mechanical resuscitation for immediate biventricular support with a consequent downgrade to right ventricular assist device after left ventricular recompensation.

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Right Heart Failure in Pulmonary Hypertension

Cited by 54 publications

References 77 publications

Echocardiographic Prognosis Relevance of Attenuated Right Heart Remodeling in Idiopathic Pulmonary Arterial Hypertension

Echocardiographic Prognosis Relevance of Attenuated Right Heart Remodeling in Idiopathic Pulmonary Arterial Hypertension

RNA Methylations in Cardiovascular Diseases, Molecular Structure, Biological Functions and Regulatory Roles in Cardiovascular Diseases

Dual-outflow extracorporeal membrane oxygenation support in secondary right ventricular failure

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