Right foot congenital infantile fibrosarcoma treated only with chemotherapy

Demir, Hacı Ahmet; Akyüz, Canan; Varan, Ali; Ergen, Fatma Bilge; Büyükpamukçu, Münevver

doi:10.1002/pbc.22389

Cited by 18 publications

(13 citation statements)

References 16 publications

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“…Another study showed a rate of 21 % [14]. Lymphadenectomy is usually not warranted, because IFS seldom metastasizes to lymph nodes, but two case reports have described regional lymph node metastasis [17, 18]. We did not observe any regional lymph node metastasis, except for positive omental lymph nodes in the patient with a retroperitoneal lesion.…”

Section: Discussionmentioning

confidence: 48%

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Clinical management of infantile fibrosarcoma: a retrospective single-institution review

et al. 2013

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Background Infantile fibrosarcoma (IFS) is an uncommon soft-tissue sarcoma. Here we review our experience treating this tumor. Patients and methods We retrospectively reviewed records of patients with IFS treated at St. Jude Children’s Research Hospital between 1980 and 2009. Results We identified 15 patients, 8 girls and 7 boys; 13 white and 2 black. Median age at diagnosis was 3 months. Primary sites included the leg (n = 3), chest wall (n = 2), foot (n = 2), and one each in the tongue, occipital region, axilla, parascapular region, arm, forearm, retroperitoneum, and thigh. All patients underwent resection; 11 upfront surgery, and 4 delayed. Complications included loss of the posterior tibial nerve and artery, axillary vein, biceps, pectoralis major, gallbladder, and transverse/sigmoid sinus. Eight received chemotherapy and three radiotherapy. Seven experienced local recurrence and three lung metastasis. Median follow-up was 65 months. At the time of the review, 12 patients were alive and 3 had died. All deaths were in patients older than 1 year at diagnosis with an axial primary site. Conclusions Non-mutilating surgery should be the primary treatment for IFS. Neoadjuvant chemotherapy is indicated when upfront resection is unfeasible. Patients with positive surgical margins should receive adjuvant chemotherapy. Radiotherapy is indicated for axial primary sites where complete resection is impossible.

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Section: Discussionmentioning

confidence: 48%

“…Patients have been treated with neoadjuvant chemotherapy [13, 23] or chemotherapy alone [18, 21, 22, 24]. Neoadjuvant chemotherapy should be used for extensive lesions when complete surgical excision during an upfront procedure is not possible or would result in amputation [20, 25].…”

Section: Discussionmentioning

confidence: 99%

Clinical management of infantile fibrosarcoma: a retrospective single-institution review

et al. 2013

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“…The 5-year survival rate for CIFS is high and has been reported between 84% and 93%. [10] Our patient is now two years old with no recurrence.…”

Section: Discussionmentioning

confidence: 89%

“…We have reviewed 107 cases reported in the literature in children under one year of age until 2010. [1,2,[4][5][6][7][8][9][10] About 40% of CIFS are diagnosed at birth, and 60% before 3 months. Boys are more often affected than girls (sex-ratio = 3/1 to 4/1) [11] .…”

Section: Discussionmentioning

confidence: 99%

Unusual case of congenital/infantile fibrosarcoma in a new born

Tarik¹,

Lamiae²,

Abdelouahed³

et al. 2013

Afr J Paediatr Surg

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Congenital infantile fibrosarcoma (CIFS) is a rare mesenchymal tumor that is primarily developed in the soft tissue of distal extremities and occasionally in unusual locations such as the lung and retroperitoneum. It occurs mainly in children below the age of 5 years. About 200 cases have been reported in the literature so far, very few of them in new-borns. The prognosis of this tumor is relatively good compared to adult forms. We report an unusual case of CIFS occurring in new-born mimicking an hemangioma and causing hemorrhage in the neonatal period. The tumor is located in the left arm and axilla and associated with a hand malformation. A shoulder amputation is performed after chemotherapy failure. The infant is now two-years old with no recurrence.

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“…[20] Recently, Demir et al . [24] were able to successfully treat a newborn with CFS of the right foot that had destroyed all tarsals, metatarsals and phalangeal bones, with only VAC-based chemotherapy. Spontaneous regression has also been reported in some neonatal and pediatric cases of CFS.…”

Section: Discussionmentioning

confidence: 99%