Right atrial structure and function in patients with hypertension and with chronic heart failure

Proplesch, Moritz; Merz, Allison A.; Claggett, Brian; Lewis, Eldrin F.; Dwyer, Kristin H.; Crousillat, Daniela R.; Lau, Emily S.; Silverman, Montane B; Peck, Julie; Rivero, Jose; Cheng, Susan; Platz, Elke

doi:10.1111/echo.13876

Cited by 5 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RA volume has been identified as an independent predictor of the adverse events in the patients with HF assessed on both the MRI and echocardiography (7,8). Larger RAVI and lower RAEF were associated with the 12-month HF hospitalizations or death irrespective of age, sex, and prior AF (11). This study shows the relation of BMI with the RA function measured by echocardiography that did not show a significant correlation.…”

Section: Discussionmentioning

confidence: 64%

“…An inverse association between the increased RA volume index (RAVI) and impaired RA emptying fraction (RAEF) has been reported in the patients with pulmonary arterial hypertension assessed by either echocardiography or MRI (9,10). Both the larger RAVI and lower RAEF were associated with the 12month HF hospitalizations or death irrespective of age, sex, and prior AF (11). It is unclear whether the alterations in atrial function observed in adipose patients are solely explained by the systemic effects (mechanical load, inflammation).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impaired Relaxation and Reduced Lusitropic Reserve in Atrial Myocardium in the Obese Patients

Wen

Primeßnig

Dushe

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Obesity can influence the structure and function of the atrium, but most studies focused on the relationship of body mass index (BMI) and overt left atrium (LA) dysfunction as assessed by clinical imaging. We combined the assessment of right atrium (RA) function in vivo and in vitro in obese and non-obese patients scheduled for elective cardiac surgery.Methods: Atrial structure and function were quantified pre-operatively by echocardiography. RA tissue removed for the establishment of extracorporeal support was collected and RA trabeculae function was quantified in vitro at baseline and with adrenergic stimulation (isoproterenol). Fatty acid-binding protein 3 (FABP3) was quantified in RA tissue. Results were stratified according to the BMI of the patients.Results: About 76 patients were included pre-operatively for the echocardiographic analysis. RA trabeculae function at baseline was finally quantified from 46 patients and RA function in 28 patients was also assessed with isoproterenol. There was no significant correlation between BMI and the parameters of atrial function measured by the clinical echocardiography. However, in vitro measurements revealed a significant correlation between BMI and a prolonged relaxation of the atrial myocardium at baseline, which persisted after controlling for the atrial fibrillation and diabetes by the partial correlation analysis. Acceleration of relaxation with isoproterenol was significantly lower in the obese group (BMI ≥ 30 kg/m2). As a result, relaxation with adrenergic stimulation in the obese group remained significantly higher compared to the overweight group (25 kg/m2 ≤ BMI < 30 kg/m2, p = 0.027) and normal group (18.5 kg/m2 ≤ BMI < 25 kg/m2, p = 0.036). There were no differences on impacts of the isoproterenol on (systolic) developed force between groups. The expression of FABP3 in the obese group was significantly higher compared to the normal group (p = 0.049) and the correlation analysis showed the significant correlations between the level of FABP3 in the RA trabeculae function.Conclusion: A higher BMI is associated with the early subclinical changes of RA myocardial function with the slowed relaxation and reduced adrenergic lusitropy.

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Impaired Relaxation and Reduced Lusitropic Reserve in Atrial Myocardium in the Obese Patients

Wen

Primeßnig

Dushe

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Systemic hypertension also impacts the right ventricle (RV), resulting in concentric RV remodeling and impaired RV diastolic function [ 137 , 138 ]. Numerous clinical studies have linked adverse RV remodeling to an unfavorable prognosis [ 139 , 140 , 141 ]. Right heart involvement may be attributed to pulmonary hypertension secondary to left heart conditions [ 142 ].…”

Section: Mechanisms Contributing To Hypertensive Heart Diseasementioning

confidence: 99%

Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

Huang,

Hu,

Long

et al. 2024

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Hypertensive heart disease (HHD) presents a substantial global health burden, spanning a spectrum from subtle cardiac functional alterations to overt heart failure. In this comprehensive review, we delved into the intricate pathophysiological mechanisms governing the onset and progression of HHD. We emphasized the significant role of neurohormonal activation, inflammation, and metabolic remodeling in HHD pathogenesis, offering insights into promising therapeutic avenues. Additionally, this review provided an overview of contemporary imaging diagnostic tools for precise HHD severity assessment. We discussed in detail the current potential treatments for HHD, including pharmacologic, lifestyle, and intervention devices. This review aimed to underscore the global importance of HHD and foster a deeper understanding of its pathophysiology, ultimately contributing to improved public health outcomes.

show abstract

“…A maximális JP-i volumen, illetve testfelszínre indexált ben írták le. HFrEF-betegekben a JPVI összefüggést mutatott a betegek funkcionális állapotával, valamint a mortalitás és egyéb adverz események független prediktorának bizonyult (26)(27)(28)(29)(30). Hasonló eredmények születtek PAH-populációban is (31,32).…”

Section: A Jobb Pitvar Méretének Klinikai Jelentőségeunclassified

A jobb pitvari méret és funkció noninvazív vizsgálatának módszerei és jelentőségük

Nógrádi¹,

Faludi²

2020

Cardiologia Hungarica

View full text Add to dashboard Cite

A szív képalkotó vizsgálatai hagyományosan a bal kamrára összpontosítottak, majd az utóbbi évtizedekben a bal pit-gálható a szívüregek közül utolsóként a jobb pitvar is. A pitvarméretek egy-majd kétdimenziós vizsgálata után ma már tak. A jobb pitvari morfológia és funkció részleteinek megismerése új adatokkal gazdagíthatja a diagnosztikát, valamint a rizikó és a prognózis becslését.The traditional target of the cardiovascular imaging was the left ventricle. In the last decades the left atrium and the right heart also gained importance. The development of new imaging modalities such as modern echocardiographic techniques, cardiac CT and MRI made it possible to acquire more exact and detailed knowledge of the right atrium, as the last cardiac chamber to be investigated. After the one-and two-dimensional evaluation of the right atrial size, assessment of the phases of right atrial function, providing more information on early functional impairment and compensatory mechanisms. The detailed knowledge of right atrial morphology and function allows for more exact diagnosis, risk assessment and prognostic evaluation. BevezetésRégen elmúlt már az a korszak, amikor a jobb szívfél ben. Napjainkban a jobb kamra (1, 2) mellett a jobb rek -modern echokardiográfiás technikák, CT, MRsegítségével egyre több diagnosztikus és prognosztiis.-ták, és ezek az adatok nagymértékben hozzájárultak a balszívfél-elégtelenség patofiziológiájának megértésépárhuzamosan egyre több adat áll rendelkezésre a JP-i mechanikával kapcsolatban is, amelyek figyelmet érdemelnek. Így jelen munkánk célja, hogy áttekintsük a JP-i méret-és funkció vizsgálatára szolgáló noninvazív kép-

show abstract

Right atrial structure and function in patients with hypertension and with chronic heart failure

Abstract: In an outpatient HF cohort, both lower RAEF and increased RAVI were associated with other markers of impaired cardiac function and 12-month adverse events.

Cited by 5 publications

References 29 publications

Impaired Relaxation and Reduced Lusitropic Reserve in Atrial Myocardium in the Obese Patients

Impaired Relaxation and Reduced Lusitropic Reserve in Atrial Myocardium in the Obese Patients

Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

A jobb pitvari méret és funkció noninvazív vizsgálatának módszerei és jelentőségük

Contact Info

Product

Resources

About