Riga-Fede disease (Cardarelli’s aphthae): A report of nine cases

Mohan, Ravi Prakash Sasankoti; Verma, Sankalp; Gill, Navneet; Singh, Udita

doi:10.7196/sajch.636

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…In this case, the diagnosis of RFD relied on the history of trauma from primary teeth during the practice of oral habits. The presence of multiple congenital anomalies was supplementary and in line with the described literature [ 4 ].…”

Section: Discussionsupporting

confidence: 68%

“…Diagnosis of RFD mainly relies on history and clinical examination. Differential diagnosis of lesions includes ulcerative candidiasis, syphilis, tuberculosis and lymphomas [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Riga–Fede disease can occur in infants with congenital anomalies. Also, it was found to be associated with some neuro-developmental disorders as Tourette's syndrome, congenital indifference to pain, familial dysautonomia and Lesch–Nyhan syndrome [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Congenital anomalies-associated Riga–Fede disease as an early manifestation of Lesch–Nyhan syndrome: rare entities in the same pediatric patient—a case report

Eita

2022

BMC Oral Health

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Background Riga–Fede disease is a rare begnin disorder of the oral tissues, it can be associated with congenital anomalies and neurological disturbances. Lesch–Nyhan syndrome is a rare X-linked recessive disorder characterized by neurological and behavioral manifestations. A patient can rarely be diagnosed with both diseases in a lifetime. Therefore, reporting manifestations from such disorders is important to avoid misdiagnosis and help in timely intervention. Case presentation This case report presents an 8-months-old male infant with traumatic oral ulcers from deciduous teeth. A diagnosis of Riga–Fede disease was made. Teeth grinding was performed and the oral lesions were healed. At the age of 2.5 years, the patient presented with neurological manifestations as well as facial tissue and premature teeth loss from self mutilation. Genetic sequencing revealed a variant of uncertain significance in the Hypoxanthine Phosphoribosyltransferase 1 gene. He was diagnosed with Lesch–Nyhan syndrome. Cleft palate, ventricular septal defect, congenitally undescended testis and ectopic left iliac kidney were also reported. The patient was scheduled on psychiatric treatment and after about six months of follow-up, both the behavioral and neurological symptoms were improved. Conclusions Riga–Fede disease can be an early manifestation of Lesch–Nyhan syndrome. To the best of our knowledge, this is the first reported case with the incidence of all the mentioned entities in one pediatric patient.

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Section: Discussionsupporting

confidence: 68%

“…Diagnosis of RFD mainly relies on history and clinical examination. Differential diagnosis of lesions includes ulcerative candidiasis, syphilis, tuberculosis and lymphomas [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Congenital anomalies-associated Riga–Fede disease as an early manifestation of Lesch–Nyhan syndrome: rare entities in the same pediatric patient—a case report

Eita

2022

BMC Oral Health

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“…In the present case, we performed extraction of the natal teeth and this offered improvement and normalization of feeding. In conclusion, as Riga Fede disease often mimics many oral malignant and benign disorders, the differential diagnosis is important [6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Riga-Fede Syndrome : A Rare Case Report With Literature Review

2023

TMOA

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Riga-Fede syndrome is characterised as an ulcerative lesion that originates on the ventral surface of a neonate’s tongue due to vigorous back and forth movements of the tongue over the precociously erupted mandibular anterior teeth. This condition has been receiving discernible attention as a progressing condition with escalating case reports over the years. The aetiology of this issue is not precisely deduced; however, there have been multiple treatment options discovered that have secured success with higher precision. The purpose of this research paper is to exhibit various case reports and aetiologies responsible for this disease, as well as an explanation of different treatment plans depending on the status of the tooth, that is, the mobility of the tooth and the precarious chances of aspiration. Moreover, radiographic study to visualise if it is a supernumerary or a primary regular tooth and if it is associated with hindrance in breast-feeding causing soft tissue injuries and the state of the child’s health. A 28-day-old female infant was presented to the oral pathology clinic with a natal tooth exhibiting grade 2 mobility along with a lesion on the ventral surface of the tongue, leading to the clinical diagnosis of Riga-Fede disease. The treatment performed, consisting of the extraction of natal teeth, was selected as the treatment of choice over more conservative treatments for the rapid resolution of the lesion and the limited risk of inadequate nutrient intake since the tooth was interfering with the feeding process. Following the extraction of the tooth, it underwent microscopic studies to identify diverse changes associated with the erupted tooth. There was regular monitoring of the patient, and complete wound healing was observed after 4 weeks. The proposed treatment was successful, and the patient is still in follow-up without recurrence of the lesion after one year. This paper presents a concise review of the literature about neonatal teeth and their role in Riga-Fede disease.

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“…Any surface of the oral mucosa may be affected; however the ventral tongue region is the most common site of occurrence of the ulcer [ 7 ]. Failure to diagnose the lesions can lead to deformity or tongue mutilation, dehydration, and inadequate intake of nutrients, resulting in medical sequelae as poor development [ 12 ]. In the case reported the patient had irritability and difficulties with breastfeeding because of the injury on the ventral surface of the tongue, which could eventually generate nutritional damage among other problems.…”

Section: Discussionmentioning

confidence: 99%

Riga-Fede Disease Associated with Natal Teeth: Two Different Approaches in the Same Case

Volpato

Simões

et al. 2015

Case Reports in Dentistry

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Natal teeth are those present in the oral cavity at the child's birth. These teeth can cause ulcers on the ventral surface of the tongue, lip, and the mother's breast characterizing the Riga-Fede Disease. The treatment depends on the tooth's mobility and the risk of aspiration or swallowing; whether it is supernumerary or regular primary teeth; whether it is causing interference in breastfeeding; breast and oral soft tissue injuries; and the general state of child's health. A 1-month-old female infant was diagnosed with two natal teeth and an ulcerated lesion on the ventral surface of the tongue, leading to the clinical diagnosis of Riga-Fede Disease. The treatment performed consisted of the maintenance of the natal tooth that showed no increased mobility, adding a small increment of glass ionomer cement to its incisal edge, and orientation for hygiene with saline solution. Due to the increased mobility of the other natal tooth, surgical removal was performed. There was regular monitoring of the patient and complete wound healing was observed after 15 days. The proposed treatment was successful and the patient is still in follow-up without recurrence of the lesion after one year.

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Riga-Fede disease (Cardarelli’s aphthae): A report of nine cases

Cited by 5 publications

References 15 publications

Congenital anomalies-associated Riga–Fede disease as an early manifestation of Lesch–Nyhan syndrome: rare entities in the same pediatric patient—a case report

Congenital anomalies-associated Riga–Fede disease as an early manifestation of Lesch–Nyhan syndrome: rare entities in the same pediatric patient—a case report

Riga-Fede Syndrome : A Rare Case Report With Literature Review

Riga-Fede Disease Associated with Natal Teeth: Two Different Approaches in the Same Case

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