Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery

Song, Xu Chun; Lin, Qing; Guo, Litao; Fu, Yao; Han, Jianfeng; Ke, Huan; Sun, Xun; Gong, Tao; Zhang, Zhirong

doi:10.1007/s11095-014-1572-3

Cited by 62 publications

(25 citation statements)

References 41 publications

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“…The particle size was found around 160 nm. The rifampicin was found to be entrapped above 90% within the system and high uptake was observed in NR8383 cells and alveolar macrophages (Song et al, 2015).…”

Section: Nanostructured Lipid Carriermentioning

confidence: 97%

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Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

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From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of emergence poses a vital challenge to control TB cases across the world. Mortality and morbidity rates are high due to this new face of TB. The newer nanotechnology-based drug-delivery approaches involving micro-metric and nano-metric carriers are much needed at this stage. These delivery systems would provide more advantages over conventional systems of treatment by producing enhanced therapeutic efficacy, uniform distribution of drug molecule to the target site, sustained and controlled release of drug molecules and lesser side effects. The main aim to develop these novel drug-delivery systems is to improve the patient compliance and reduce therapy time. This article reviews and elaborates the new concepts and drug-delivery approaches for the treatment of TB involving solid-lipid particulate drug-delivery systems (solid-lipid micro- and nanoparticles, nanostructured lipid carriers), vesicular drug-delivery systems (liposomes, niosomes and liposphere), emulsion-based drug-delivery systems (micro and nanoemulsion) and some other novel drug-delivery systems for the effective treatment of tuberculosis and role of immunomodulators as an adjuvant therapy for management of MDR-TB and XDR-TB.

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Section: Nanostructured Lipid Carriermentioning

confidence: 97%

“…NLCs mainly accommodates drug due to their highly unordered lipid structures (Kamble et al, 2012). Song et al (2015) developed nanostructured lipid carrier to encapsulate rifampicin. The particle size was found around 160 nm.…”

Section: Nanostructured Lipid Carriermentioning

confidence: 99%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

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“…Results of in vivo toxicity studies showed that capreomycin oleate exhibited its lowest toxic potential suggesting it be used as super generics in pulmonary tuberculosis treatment [73]. Outcomes of various miscellaneous lipid based drug delivery systems in the treatment of TB are summarized in Table 6 [74][75][76][77][78][79][80][81][82][83][84][85][86].…”

Section: Miscellaneous Lipid Based Formulationsmentioning

confidence: 99%

Exploring the Use of Lipid Based Nano-Formulations for the Management of Tuberculosis

Cm¹,

Cd²,

M³

et al. 2017

J Nanosci Curr Res

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Tuberculosis (TB) is an airborne infectious disease spreading very fast from person to person, which affect the health as well as socioeconomic conditions harshly. Though varieties of antitubercular drugs (ATDs) are available for its treatment, associated stern side effects restrict the patients to receive complete therapeutic benefits. Moreover, emergence of drug-resistant tuberculosis and co-infection of TB with HIV further worsen the situations. Polymeric formulations are introduced for progressive and long-term delivery of therapeutic agents, but owing to their noted limitations, performance is not up to the mark. In this juxtaposition, lipid based nano-formulations are introduced as an alternative to the polymic formulations in the management of TB with an intention to overcome side effects related to drugs along with limitations of polymeric formulations. The lipid based formulations comprise nanoemulsions, solid-lipid nanoparticles (SLNs), nano-structured lipid carriers (NLCs), liposomes, and niosomal systems, etc.Liposomes have more promising antitubercular activity as its intended for targeted drug delivery especially to the infected part. Further mannosylation of liposomes offers tremendous results in TB chemotherapy as it directly binds to mannose receptors available on the surface of alveolar macrophages resulting mycobacterium destruction. Niosomes may have superior drug targeting ability, chemical stability, osmotic activeness and in vivo activity in comparison to that of liposomes. SLNs and manosylated SLNs are the advanced form of the lipid formulations which enhance the drug uptake at the infected organ and show significant in vivo anti-tubercular activity with reduced toxicity. Moreover, NLCs shows its satisfactory potential against MTb along with drug targeting action. Advancement on the development of miscellaneous or other vesicular lipid formulations are not encouraging in the field of tubercular chemotherapy. Hence, lipid based formulations could be successfully employed for targeted delivery of ATDs with promising anti-tubercular activity.

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“…Nanostructured lipid carriers (NLCs) employ a blend of both sold and liquid lipids and Song et al utilised this technique to produce cationic mannosylated NLCs for the targeted delivery of rifampicin to alveolar macrophages. With an encapsulation efficiency of >90% and a diameter of approximately 160 nm, mannosylated rifampicin NLCs displayed grater macrophage targeting and uptake than unmodified rifampicin NLCs in both a NR8383 cell line and in vivo after intravenous administration without causing undue inflammation or toxicity [246]. Equally, solid lipid particles can be formed as solid lipid microparticles (SLMs) for suitability in a range of applications.…”

Section: Lipid Based Drug Delivery Systemsmentioning

confidence: 99%

Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

O'Connor

Gleeson

Fagan-Murphy

et al. 2016

Advanced Drug Delivery Reviews

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Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery

Abstract: RFP-Man-NLCs provided an alternative strategy for selectively delivering rifampicin to alveolar macrophages.

Cited by 62 publications

References 41 publications

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

Exploring the Use of Lipid Based Nano-Formulations for the Management of Tuberculosis

Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

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