Exploring the Use of Lipid Based Nano-Formulations for the Management of Tuberculosis

Cm, Bibhas; Cd, Subas; M, Gitanjali; Np, Narahari

doi:10.4172/2572-0813.1000112

Cited by 3 publications

References 57 publications

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Poly(lactic-co-glycolic) Acid–Lipid Hybrid Microparticles Enhance the Intracellular Uptake and Antibacterial Activity of Rifampicin

Maghrebi

Joyce

Jambhrunkar

et al. 2020

ACS Appl. Mater. Interfaces

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An urgent demand exists for the development of effective carrier systems that systematically enhance the cellular uptake and localization of antibiotic drugs for the treatment of intracellular pathogens. Commercially available antibiotics suffer from poor cellular penetration, restricting their efficacy against pathogens hosted and protected within phagocytic cells. In this study, the potency of the antibiotic rifampicin against intracellular small colony variants of Staphylococcus aureus was improved through encapsulation within a strategically engineered cellpenetrant delivery system, composed of lipid nanoparticles encapsulated within a poly(lactic-co-glycolic) acid (PLGA) nanoparticle matrix. PLGA−lipid hybrid (PLH) microparticles were synthesized through the process of spray drying, whereby rifampicin was loaded within both the polymer and lipid phases, to create a nanoparticle-in-microparticle system capable of efficient redispersion in aqueous biorelevant media and with programmable release kinetics. The ability of PLH particles to disintegrate into nanoscale agglomerates of the precursor nanoparticles was shown to be instrumental in optimizing rifampicin uptake in RAW264.7 macrophages, with a 7.2-and 1.6-fold increase in cellular uptake, when compared to the pure drug and PLGA microparticles (of an equivalent initial particle size), respectively. The enhanced phagocytosis and extended drug release mechanism (under the acidic macrophage environment) associated with PLH particles induced a 2.5-log reduction in colony forming units compared to initial colonies at 2.50 μg/mL rifampicin dose. Thus, the ability of PLH particles to reduce the intracellular viability of S. aureus, without demonstrating significant cellular toxicity, satisfies the requirements necessary for the safe and efficacious delivery of antibiotics to macrophages for the treatment of intracellular infections.

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Poly(lactic-co-glycolic) Acid–Lipid Hybrid Microparticles Enhance the Intracellular Uptake and Antibacterial Activity of Rifampicin

Maghrebi

Joyce

Jambhrunkar

et al. 2020

ACS Appl. Mater. Interfaces

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Quercetin and Morin dual drug loaded nanostructured lipid carriers: formulation and in vitro cytotoxicity study on MCF7 breast cancer cells

Palei,

Mounika,

Mohanta

et al. 2023

Journal of Dispersion Science and Technology

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Solid Lipid Based Nano-particulate Formulations in Drug Targeting

Mohanta¹,

Dinda²,

Palei³

et al. 2020

Role of Novel Drug Delivery Vehicles in Nanobiomedicine

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Recently, targeted drug delivery systems have gained much more interest for delivering varieties of drugs as well as imaging agents specifically to the targeted disease cells or tissues. These are well known for their increased precision and accuracy in mode of drug delivery along with reduced side effects. Though numerous carriers are being employed for drug targeting, the solid lipid based nanoparticles (SLNs) are preferred over them owing to their ability to encapsulate wide varieties of drugs, biocompatibility, ease of surface modification, scaling up feasibility, and possibilities of both active as well as passive targeting to various organs. Surface of these drug loaded SLNs can be modified by conjugating different ligands to enhance their tissue/organ targeting ability and therapeutic efficacy to much higher extent. In this chapter, we have discussed about the SLNs and their different surface modified forms for passive as well as active targeting to different organ such as (colon, breast, lungs, liver, kidney, brain, eyes, etc.) in combating different diseases.

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Exploring the Use of Lipid Based Nano-Formulations for the Management of Tuberculosis

Cited by 3 publications

References 57 publications

Poly(lactic-co-glycolic) Acid–Lipid Hybrid Microparticles Enhance the Intracellular Uptake and Antibacterial Activity of Rifampicin

Poly(lactic-co-glycolic) Acid–Lipid Hybrid Microparticles Enhance the Intracellular Uptake and Antibacterial Activity of Rifampicin

Quercetin and Morin dual drug loaded nanostructured lipid carriers: formulation and in vitro cytotoxicity study on MCF7 breast cancer cells

Solid Lipid Based Nano-particulate Formulations in Drug Targeting

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