Riesgo de fenómenos tromboembólicos en pacientes con enfermedad inflamatoria intestinal

Ferrer, Cristina Suárez; Mendoza, María Isabel Vera; Román, Leticia Amo San; Lama, Yago González; Moya, Marta Calvo; Casas, M. García; García, L. Abreu

doi:10.1016/j.gastrohep.2012.07.003

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…showed that more extensive involvement and severe inflammatory activity were risk factors for thrombosis in IBD patients and no significant association between classical risk factors such as the use of contraceptives, pregnancy, coagulation disorders or smoking, and the risk of thromboembolic phenomena were found. [22] These results are similar to our study; however, unlike our finding, none of their patients had a family history of thrombosis. Regarding the genetic factor in IBD, one study found that increased prevalence of hyperhomocysteinemia in IBD patients might account for the thrombotic risk.…”

Section: Discussionsupporting

confidence: 90%

Thromboembolic events in patients with inflammatory bowel disease

Algahtani¹,

Farag²,

Aljebreen³

et al. 2016

Saudi J Gastroenterol

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Background/Aims:Inflammatory bowel disease (ulcerative colitis and Crohn's disease) is characterized by a chronic inflammatory condition, and is accompanied by abnormalities in coagulation and a hyper-coagulable state. This study was conducted to examine the risk factors for developing Thromboembolic Events in Inflammatory Bowel Disease (IBD) in a population with prevalent consanguinity.Patients and Methods:Patients with a definitive diagnosis of IBD who were seen in the gastroenterology clinic of King Khalid University Hospital (Riyadh, Saudi Arabia) from 2010- to 2012, were asked to participate in this prospective cohort study, and were followed for one 1 year. Data was collected using specifically designed case report forms (CRF) by trained research personnel.Results:A total of 100 Saudi patients with IBD were studied. There were 51 (51%) women and the mean ± standard deviation (SD) age of the group was 31.24 ± 10.78 years. Those with Crohn's disease constituted 72% of the patients, and 28% had ulcerative colitis. Eight patients (8%) had at least one Thrombotic Event ([six deep venous thrombosis (DVT), and two pulmonary embolism (PE)]. Family history of deep venous thrombosis was present in 5%, and family history of pulmonary embolism (PE) in 4% of the patients. After adjusting for age and gender, a family history of Thrombotic event was identified as to be the only statistically significant predictor of thrombosis in IBD patients (RR = 9.22, 95% CI: 2.10--40.43).Conclusion:In a population with high consanguinity, Thromboembolic events (DVT and PE) had a prevalence of 8% among IBD patients, positive family history of pulmonary embolism was a predictor of thrombosis. Further studies are needed to explore the role of genetic factors in this population.

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Section: Discussionsupporting

confidence: 90%

Thromboembolic events in patients with inflammatory bowel disease

Algahtani¹,

Farag²,

Aljebreen³

et al. 2016

Saudi J Gastroenterol

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“…The risk of TE is estimated to be almost three times higher in males than in females [ 21 ]. Some authors reported an increased risk of TE in pregnant IBD women when compared with the non-IBD obstetric population [ 22 , 23 ], but others did not [ 24 ]. Generally most of TE occur during active disease, even if a high rate of thrombosis (almost one third) is reported during remission and well controlled disease, supporting the hypothesis of a greater pro-thrombotic tendency in IBD independent of disease activity [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Thrombosis in inflammatory bowel diseases: what’s the link?

et al. 2015

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Inflammatory bowel disease affects more than 2 million people in Europe, with almost 20% of patients being diagnosed in pediatric age. Patients with inflammatory bowel disease are at increased risk of thromboembolic complications which may affect patients’ morbidity and mortality. The risk of the most common thromboembolic events, such as deep venous thrombosis and pulmonary embolism, are estimated to be three-fold increased compared to controls, but many other districts can be affected. Moreover, patients with ulcerative colitis and Crohn’s disease experience thromboembolic events at a younger age compared to general population. Many factors have been investigated as determinants of the pro-thrombotic tendency such as acquired risk factors or genetic and immune abnormalities, but a unique cause has not been found. Many efforts have been focused on the study of abnormalities in the coagulation cascade, its natural inhibitors and the fibrinolytic system components and both quantitative and qualitative alterations have been demonstrated. Recently the role of platelets and microvascular endothelium has been reviewed, as the possible link between the inflammatory and hemostatic process.

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