Ridge preservation of a novel extraction socket applying Bio-Oss® collagen: An experimental study in dogs

Abstract

Background Bio-Oss® collagen (BC) has been used in clinical applications for years but the ridge preservation property of BC remains controversial. There is no animal model accurately simulates the extraction socket in people. The aim of this study was to assess the ridge preservation of a novel extraction sockets with a thin buccal plate using BC. Materials and methods Two beagle dogs were used to assess the characterization of the novel extraction socket. The width and height of the socket were measured and biopsies of the socket were collected for histologic examination. Four beagle dogs were used to assess the ridge preservation property of BC. BC was placed in the socket and socket left untreated was set as control group (CT). Cone-beam computed tomography analysis, histological examination, and micro-CT analysis were used to evaluate the ridge preservation. Results The novel extraction socket had obvious larger volume with a markedly narrow buccal wall than mandible extraction sockets. At 12 weeks, the width of the crest of the alveolar ridge preservation ratios was 34% for the CT and 82% for the BC. BC group had larger socket volume compare to CT group. BC group had a significant higher bone density in the middle and apical areas of the alveolar bone. Socket placed with BC showed significantly less vertical bone loss compared with CT group. Conclusion Extraction site with a significantly larger dimension and a very thin buccal plate was established. Extraction sockets filled with BC exhibit excellent maintenance of alveolar bone volume.

Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth

“…DBBM is a classical xenogeneic bone graft material, which is made from deorganized bovine limb bone, and generally biocompatible and structurally similar to human bone. DBBM has been developed as the preferred alternative bone material and used in restoration of bone defects around implants, ridge preservation after extraction [ 10 ], maxillary sinus augmentation [ 11 ], treatment of cyst and generally resulted in new attachment and cementum formation when compared to ungrafted sites.…”

Influence of Xenogeneic and Alloplastic Carriers for Bone Augmentation on Human Unrestricted Somatic Stem Cells

“…In vivo, it offers great volume stability and remains insoluble [ 32 ]. Extraction sockets filled with BO show excellent maintenance of alveolar bone volume [ 33 ]. NB is a purely alloplastic material containing 61% nanocrystalline hydroxyapatite and 39% silica gel SiO 2 .…”

“…However, the used dental biomaterials have already been tested in in vivo studies. Results show decent to good regenerative potential for all materials tested (ICBM [ 6 ], Bio Oss [ 5 , 33 ], Nanobone [ 37 , 51 ].…”

A Comparative Study of Two Bone Graft Substitutes—InterOss® Collagen and OCS-B Collagen®

“…A composite scaffold combining the advantages of particulate grafts with biopolymers, such as proteins, is often used to overcome the limitations of the use of barrier membrane and contain particulate migration [ 22 ]. Several composite bone grafts are commercially available that combine Collagen Type I, the most abundant protein in human body, with bovine hydroxyapatite granules in various ratios to form into spongious scaffolds with an interconnected pore structure allowing easier migration of bone regenerative cells [ 23 , 24 , 25 , 26 ]. Bone predominantly constitutes of calcium phosphate (non-stoichiometric carbonate- substituted hydroxyapatite crystals) embedded in collagen matrix.…”

“…Bio-Oss Collagen implanted in extraction socket showed larger bone socket volume compare to control (untreated) group. In addition, Bio-Oss Collagen showed significant higher bone density in the middle and apical areas of the alveolar bone [ 25 ]. A clinical study in humans assessed the vertical and horizontal alterations of buccal alveolar bone after the immediate insertion of an implant together with Bio-Oss ® Collagen.…”