Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth

Abstract

Objective To investigate the clinical effect of concentrated growth factors (CGF) combined with deproteinized bovine bone mineral (DBBM) on Alveolar ridge preservation during implantology. Methods A total of 38 patients were selected and randomly divided into 2 groups, with 19 cases in each group. The extraction sockets were filled with DBBM with or without CGF. Visual analogue scale (VAS) pain score was recorded within1 week and Landry wound healing index (LWHI) was recorded at 1, 2 and 3 weeks after operation. CBCT was taken preoperatively and 3 and 6 months postoperatively to measure and compare the changes of vertical height, width and gray value of alveolar bone at extraction site. The changes of alveolar bone contour were observed clinically and compared between the two groups. Results The VAS score of CGF group was lower than control group on the 1st and 3rd day after operation (P < 0.05). The LWHI of CGF group was higher than control group 1 week after operation (P < 0.05). The absorption of the labial and palatal plates height and the width in the CGF group was significantly less than the control group at 3 months (P < 0.05). The gray value of alveolar bone in CGF group was significantly higher than control group at 3 months (P < 0.05). There was no significant difference in new bone contour between the two groups (P > 0.05). 94.7% cases in CGF group did not undergo bone grafting, which was significantly higher than control group (78.9%). Conclusions The use of CGF combined with DBBM can help to reduce postoperative pain at the early stage of healing, form sufficient keratinized gingival tissue, effectively maintain the height and width of alveolar bone in the three-dimensional direction and provide good conditions for implant repair in the future.

Analysis of the effects of concentrated growth factor and low-level laser therapy on the bone healing

“…PRF or CGF combined with other biomaterials are considered to give better results for bone healing [ 21 , 22 ]. The application of this combination is widely used in dental surgery [ 23 , 24 ]. The results of previous studies showed that the combined with PRF and LLLT did not show a synergistic effect in the process of bone healing [ 25 , 26 , 27 ].…”

Tomographic Evaluation of Alveolar Ridge Preservation Using Bone Substitutes and Collagen Membranes—A Retrospective Pilot Study

“…Alveolar ridge preservation (ARP) is synonymous with terms such as socket grafting, socket preservation, socket augmentation and ridge preservation [ 7 , 8 , 9 , 10 ]. It is a concept first suggested in 1994 that is a regenerative intervention on sites which require delayed implant placement [ 11 ]. Regardless of technique, dimensional changes after extraction cannot be completely avoided.…”

Preservação do rebordo alveolar e gengiva ceratinizada utilizando matriz dérmica de colágeno e substituto ósseo inorgânico em extrações sem retalho. Uma série de casos de biomaterial exposto ao meio bucal

“…Ambos os grupos atingiram bons resultados de avaliação de cicatrização e ferida, acima de 60% dos escores máximos. Um estudo, avaliando a PRA com retalho e utilizando EOBI e uma membrana de colágeno reabsorvível na 1ª semana pós operatória, obteve ICM 2,50 ± 0,62 menor que a média obtida pelo G2 que utilizou EOBI e MDC e os deixou intencionalmente expostos no mesmo tempo de avaliação (KERANMU et al, 2022).…”

“…Apesar deste estudo utilizar o ICM descrito por LANDRY et al, (1988), ele não deixou claro o score máximo e se foi avaliado todos os itens do ICM (KERANMU et al, 2022).…”