Rice Gruel and Rice Starch Reduce Sorbitol-Induced Diarrhoea in Cecectomized Rats

Islam, Md. Shahidul; Nishiyama, Akiko; Sakaguchi, Ei

doi:10.1159/000087398

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…13 R-ORS is effective in the treatment of all forms of gastroenteritis, including cholera, according to results from a randomized clinical trial, but its efficacy does not exceed that of G-ORS. 14 Previous investigations using animal models confirmed these findings; it was seen that gruel-and rice-starch-based groups experienced significantly shorter bouts of diarrhea compared to the control group. 66 Consistent with these results, another study found no statistically significant difference between two groups who were given either G-ORS or enriched glucose with amylase-resistant starch, despite the fact that G-ORS resulted in a higher frequency of stools.…”

Section: Discussionmentioning

confidence: 71%

Comparison of Glucose ORS with and without Rice Based ORS in Treatment of Acute Gastroenteritis from 6 Month to 5 Years

Iftikhar¹,

Ahmad²,

Khalid³

et al. 2023

PJMHS

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Introduction: Acute gastroenteritis-related diarrhea is a major contributor to pediatric morbidity and mortality. Although the success of various oral rehydration formulations varies and the treatment of choice ultimately depends on the underlying reason, oral rehydration remains crucial for efficient early therapies. Objective: To compare outcome of Glucose ORS with and without rice based ORS in treatment of acute gastroenteritis from 6 month to 5 years in terms of mean stool frequency. Study Design: Randomized clinical trial Settings: The study will be done at department of Peads Ittifaq Hospital Lahore from 9 December 2018 to 19 June 2019. Sample Technique: Non probability consecutive sampling Methodology: Children of both sexes were included in this analysis of gastroenteritis cases between the ages of 6 months and 5 years. They divided into two separate groups. For 48 hours, group A was given G-ORS, whereas group B was given rice soup. Over the course of 48 hours, the typical individual needs to use the washroom. Results: Eighty people took part in the study (forty in each group). There were 25 males in Group A (40.02%), and 26 in Group B (50.98%). The average ages of those in Group A and Group B were very comparable (3.30±1.18 vs. 2.07±1.03 years, p=0.29). The baseline stool frequency of Group A was 4.11±2.33, while that of Group B was 5.01±2.81 (p= 0.51). Group A also had a higher mean weight, at 6.87±1.97, than Group B, at 6.28±2.01. Group A had an average of 2.15±0.77 bowel movements in 48 hours, while Group B had an average of 2.08±0.73 (p=0.91). The mean frequency was 2.170.78 for males, 2.14±0.69 for females, and 2.11±0.72 for both sexes combined (p=0.91). There were no statistically significant differences in age, BMI over 10, or baseline frequency. Practical implication: The purpose of this research was to more exactly explain the authentic benefit of rice-based ORS in comparison to glucose ORS and to evaluate whether or not there is significant differences. Conclusion: Both groups reduced the number of incidences of the confounding variable roughly at the same rate, and there was no statistically significant difference between them either in terms of that reduction or in terms of stratification of any of the study's other confounding variables. Keywords: G-ORS, Gastroenteritis, Stool frequency, Rice soup

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Section: Discussionmentioning

confidence: 71%

Comparison of Glucose ORS with and without Rice Based ORS in Treatment of Acute Gastroenteritis from 6 Month to 5 Years

Iftikhar¹,

Ahmad²,

Khalid³

et al. 2023

PJMHS

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“…A randomized clinical trial revealed that although R-ORS is effective in the treatment of diarrhea caused by vibrio cholerae, its effect does not exceed that of G-ORS (16). A study on rats having diarrhea from sorbitol found that the duration of diarrhea in gruel-based and rice-starch groups decreased compared with that of the control group (20). In another study, diarrhea duration in the group received enriched glucose with amylase-resistant starch was less than that of the G-ORS group (21).…”

Section: Discussionmentioning

confidence: 95%

The Effect of G-ORS Along With Rice Soup in the Treatment of Acute Diarrhea in Children: A Single-Blind Randomized Controlled Trial

Kianmehr¹,

Saber²,

Moshari³

et al. 2016

Nurs Midwifery Stud

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Background: The world health organization guidelines for treatment of diarrhea in children emphasize on continued feeding together with prescription of oral rehydration solution (ORS) and supplementary zinc therapy. However, conflicting viewpoints exist regarding the optimal diet and dietary ingredients for children with diarrhea. Moreover, few studies have investigated the effect of rice soup along with ORS in the treatment of this disease.

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“…In a previous study, consumption of 7% sugar alcohol induced diarrhea in rats, and this diarrhea was reduced by a diet containing 5% sorbitol in cecectomized rats (39). Therefore, we considered 5% sugar alcohol in the diet to be the maximum proportion of sugar alcohol that could be expected to reveal the effects of mannitol consumption under normal conditions without diarrhea in cecectomized rats.…”

Section: Generalmentioning

confidence: 99%

Mannitol Lowers Fat Digestibility and Body Fat Accumulation in Both Normal and Cecectomized Rats

Nishiyama

Nishioka

Islam

et al. 2009

J Nutr Sci Vitaminol

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Summary Mannitol is a six-carbon sugar alcohol that is widely distributed in plants. Sugar alcohols are widely used in various food products because of their numerous beneficial health effects. The present study investigated the effects of mannitol consumption on digestion, large gut fermentation and nutrient metabolism in normal and cecectomized male Wistar rats. After 28 d of feeding with three kinds of diet containing 0, 4 or 8% mannitol, mannitol consumption dose-dependently lowered the digestibilities of crude fat and crude protein, the ratio of body fat accumulation to energy absorbed and the hepatic and serum triglyceride levels in normal rats. After 24 d of feeding with three kinds of diet comprising a control diet, a 5% mannitol-containing diet and a 5% fructooligosaccharides (FOS)-containing diet, mannitol lowered the digestibility of fat and the ratio of body fat accumulation to energy consumed and absorbed in cecectomized rats. On the other hand, FOS consumption had no effect on the accumulation of body fat, but lowered the digestibility of fat. FOS consumption greatly improved the accumulation of body ash in cecectomized rats. These results suggest that mannitol has a lowering effect on body fat accumulation, and further indicate that the cecum is not essential for the appearance of effects of mannitol on digestion, absorption and metabolism. Key Words mannitol, digestion, fat accumulation, rat, cecum Excessive accumulation of body fat is considered to be a major risk factor for several chronic disease conditions such as coronary heart disease, cancer, diabetes and hypertension. Fatness is also a specific reason for the persistence of chronic fatty liver, representing one of the major causes of hepatic diseases such as acute steatohepatitis and chronic liver failure ( 1 ). Proper weight management is one of the key components of a healthy lifestyle that avoids the onset of these diseases.Mannitol is a naturally-occurring six-carbon sugar alcohol or polyol that is widely distributed in plants, including algae, onions, grasses, olives and pumpkins. It is used as an osmotic diuretic and cleared by the kidneys, in a similar manner to inulin ( 2 ). Mannitol is not easily digested in the small intestine, but is fermentable in the large intestine ( 3 , 4 ). In a previous study, up to 50% of uniformly labeled 14 C-mannitol orally administered to humans was recovered in urine and stool samples after 48 h and as much as 18% of a dose was recovered as expired CO 2 , whereas little metabolism was observed after intravenous administration ( 5 ). In another human study, the blood glucose level and respiratory quotient remained unaffected within 2 h after administration of mannitol ( 6 ). These findings suggest that part of the ingested mannitol is utilized as an energy source, possibly after being metabolized to organic acids by intestinal microflora and absorbed from the large intestine, although mannitol can be used as a sweetener by people with diabetes.Non-digestible but fermentable oligosaccharides stimulate...

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Rice Gruel and Rice Starch Reduce Sorbitol-Induced Diarrhoea in Cecectomized Rats

Cited by 6 publications

References 51 publications

Comparison of Glucose ORS with and without Rice Based ORS in Treatment of Acute Gastroenteritis from 6 Month to 5 Years

Comparison of Glucose ORS with and without Rice Based ORS in Treatment of Acute Gastroenteritis from 6 Month to 5 Years

The Effect of G-ORS Along With Rice Soup in the Treatment of Acute Diarrhea in Children: A Single-Blind Randomized Controlled Trial

Mannitol Lowers Fat Digestibility and Body Fat Accumulation in Both Normal and Cecectomized Rats

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