Rice bran extract protects from mitochondrial dysfunction in guinea pig brains

Hagl, Stephanie; Kocher, Alexa; Schiborr, Christina; Eckert, Schamim H.; Ciobanu, Ion; Birringer, Marc; El‐Askary, Hesham I.; Helal, Amr M.; Khayyal, Mohamed T.; Frank, Jan; Müller, Walter E.; Eckert, Gunter P.

doi:10.1016/j.phrs.2013.06.008

Cited by 54 publications

(53 citation statements)

References 71 publications

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“…Dissociated brain cells (DBC) were prepared from one brain hemisphere according to a previously published protocol (Hagl et al 2013). Measurement of mitochondrial membrane potential (MMP) and ATP concentrations was accomplished as described elsewhere (Hagl et al 2013).…”

Section: Preparation Of Dissociated Brain Cells and Measurement Of MMmentioning

confidence: 99%

“…We recently reported that a stabilized rice bran extract containing vitamin E congeners and c-oryzanol had beneficial effects on mitochondrial function in PC12 cells (Hagl et al 2015a) and in the brains of young guinea pigs (Hagl et al 2013). Furthermore, the extract improved mitochondrial dysfunction in a cell culture model of AD (Hagl et al 2015b) as well as in the brains of aged NMRI mice (Hagl et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice

et al. 2016

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Aging represents a major risk factor for the development of neurodegenerative diseases like Alzheimer's disease (AD). As mitochondrial dysfunction plays an important role in brain aging and occurs early in the development of AD, the prevention of mitochondrial dysfunction might help to slow brain aging and the development of neurodegenerative diseases. Rice bran extract (RBE) contains high concentrations of vitamin E congeners and γ-oryzanol. We have previously shown that RBE increased mitochondrial function and protected from mitochondrial dysfunction in vitro and in short-term in vivo feeding studies. To mimic the use of RBE as food additive, we have now investigated the effects of a long-term (6 months) feeding of RBE on survival, behavior and brain mitochondrial function in aged NMRI mice. RBE administration significantly increased survival and performance of aged NMRI mice in the passive avoidance and Y-maze test. Brain mitochondrial dysfunction found in aged mice was ameliorated after RBE administration. Furthermore, data from mRNA and protein expression studies revealed an up-regulation of mitochondrial proteins in RBE-fed mice, suggesting an increase in mitochondrial content which is mediated by a peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α)-dependent mechanism. Our findings suggest that a long-term treatment with a nutraceutical containing RBE could be useful for slowing down brain aging and thereby delaying or even preventing AD.

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Section: Preparation Of Dissociated Brain Cells and Measurement Of MMmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice

et al. 2016

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“…RB has various biological effects such as antiinflammatory, cholesterol-lowering, antioxidant, and anti-diabetic activities (Gohil et al 2012). Key components of RB are fiber and several kinds of antioxidants such as ferulic acid (FA), phytic acid, oryzanols, tocopherols, and tocotrienols (Hagl et al 2013). FA (4-hydroxy-3-methoxycinnamic acid) is a phenolic compound present in plant tissue.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury

Baek

Kim

Song

et al. 2014

Animal Cells and Systems

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(2014) Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury, Animal Cells and Systems, 18:2, 93-100, DOI: 10.1080DOI: 10. /19768354.2014 To link to this article: https://doi.org/10. 1080/19768354.2014 Cerebral ischemia is clinically characterized by a partial functional neurological deficit, which represents one of the leading causes of death. This study aimed to determine whether rice bran extract (RB), ferulic acid (FA), or rice bran extract supplemented with FA (RB + FA) promote functional recovery from ischemic injury. Focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in rats. Four groups were studied, including (1) vehicle group, (2) RB 5%, 10%, and 20% groups, (3) FA group, and (4) RB + FA group. Animals were injected with RB or FA once a day for 3 days after MCAO. In this study's results, the RB 20% and FA groups significantly improved neurological functions compared with the vehicle group. The RB + FA group produced more recovery from functional deficits than the other groups. Moreover, the RB 20%, FA, and RB + FA groups enhanced the antiapoptotic effect in the cortex and neural cell densities in the hippocampal DG and CA1. The RB 20%, FA, and RB + FA groups stimulated not only the expression of neurotrophic factor and antioxidant genes but also neuronal nuclei (NeuN), synaptophysin, and glutamic acid decarboxylase 67 (GAD67) proteins. Our finding indicates that the combination of RB + FA treatment showed the most synergic effect in functional recovery with ischemic brain through the stimulation of the nuclear factor-E2-related factor 2, brain-derived neurotrophic factor NeuN, SYP, and GAD67 expressions.

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“…For example, in chronic fatigue syndrome patients there is evidence of oxidative damage to mitochondrial DNA and lipids [37]. Alterations of mitochondrial efficiency and function are mainly related to alterations in mitochondrial content, Failure in the electron transport system leads to the production of reactive oxygen species (ROS) such as hydrogen peroxide that can damage macromolecules and thus lead to dysfunctional cell components or even apoptosis [52]. Failure to maintain mitochondrial function results in failure to generate energy and increased free-radical production, converging mitochondrial permeability transition, mitochondrial depolarization, intracellular glutathione depletion and cytochrome c release and this will result energy impairment, oxidative stress, and also early apoptotic cell death.…”

Section: International Journal Of Physical Medicine and Rehabilitationmentioning

confidence: 99%

Mechanism of Mitochondrial Dysfunction during Chronic Fatigue

Muluye¹,

Bian²

2017

Int J Phys Med Rehabil

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A clinically defined condition characterized by persistent, severe, disabling fatigue lasting more than six months that is not reversed by sleep is regarded as chronic fatigue (CF). Fatigue is a complex phenomenon determined by several factors, including psychological health but at the biochemical level fatigue is related to the metabolic energy available to tissues and cells, mainly through mitochondrial respiration. Fatigue is the most common symptom of poorly functioning mitochondria. therefore dysfunction of these organelles may be the cause of the fatigue seen in CF. There is a great progress in the molecular understanding of mitochondrial disorder but the relation of mitochondrial dysfunction with CF and the underlying mechanism is not identified well in addition treatment of fatigue is still inadequate. In this review we try to summarize the relation between CF with mitochondrial dysfunction and determine the underline mechanism.

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Rice bran extract protects from mitochondrial dysfunction in guinea pig brains

Cited by 54 publications

References 71 publications

Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice

Effects of Long-Term Rice Bran Extract Supplementation on Survival, Cognition and Brain Mitochondrial Function in Aged NMRI Mice

Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury

Mechanism of Mitochondrial Dysfunction during Chronic Fatigue

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