Riboflavin Deficiency and Iron Absorption in Adult Gambian Men

Fairweather‐Tait, Susan J.; Powers, Hilary J.; Minski, M.J.; Whitehead, J.; Downes, R.

doi:10.1159/000177696

Cited by 46 publications

(34 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…with a placebo (35). In lactating Guatemalan women, we found that adding riboflavin to iron supplements improved plasma ferritin marginally more than did iron supplementation alone, although hemoglobin concentrations were not increased after 2 mo of supplementation with iron, riboflavin, or both (LH Allen, MT Ruel, JE Casterline, and LM Rogers, unpublished observations, 2000).…”

Section: Figurementioning

confidence: 82%

Lack of hemoglobin response to iron supplementation in anemic Mexican preschoolers with multiple micronutrient deficiencies

Allen

Rosado²,

Casterline³

et al. 2000

The American Journal of Clinical Nutrition

147

View full text Add to dashboard Cite

Background:In developing countries, incomplete resolution of anemia with iron supplementation is often attributed to poor compliance or inadequate duration of supplementation, but it could result from deficiencies of other micronutrients. Objective: Our objective was to assess children's hematologic response to supervised, long-term iron supplementation and the relation of this response to other micronutrient deficiencies, anthropometry, morbidity, and usual dietary intake. Design: Rural Mexican children aged 18-36 mo (n = 219) were supplemented for 12 mo with either 20 mg Fe, 20 mg Zn, both iron and zinc, or placebo. Children were categorized as iron-unsupplemented (IUS; n = 109) or iron supplemented (IS; n = 108). Hemoglobin, hematocrit, mean corpuscular volume, mean cell hemoglobin, plasma concentrations of micronutrients that can affect hematopoiesis, anthropometry, and diet were assessed at 0, 6, and 12 mo; morbidity was assessed biweekly. Results: At baseline, 70% of children had low hemoglobin (≤ 115 g/L), 60% had low hematocrit, 48% were ferritin deficient, 10% had deficient and 33% had low plasma vitamin B-12 concentrations, 29% had deficient vitamin A concentrations, and 70% had deficient vitamin E concentrations. Iron supplementation increased ferritin from 11 ± 14 g/L at baseline to 31 ± 18 g/L after 6 mo (P < 0.001) and 41 ± 17 g/L after 12 mo. However, anemia persisted in 30% and 31% of supplemented children at 6 and 12 mo, respectively, and was not significantly different between the IUS and IS groups at 12 mo. Initial plasma vitamin B-12, height-for-age, and dietary quality predicted the hematopoietic response to iron. Conclusion: Lack of hemoglobin response to iron was associated with indicators of chronic undernutrition and multiple micronutrient deficiencies.

show abstract

Section: Figurementioning

confidence: 82%

Lack of hemoglobin response to iron supplementation in anemic Mexican preschoolers with multiple micronutrient deficiencies

Allen

Rosado²,

Casterline³

et al. 2000

The American Journal of Clinical Nutrition

147

View full text Add to dashboard Cite

show abstract

“…Diabetes risk (718) ; insulin secretion (157,786) ; blood pressure (787) ; CVD (788 -790) ; cardiac arrhythmias (791) ; kidney health (792) and stones (793) ; bone health (794) ; hypercalciura (795) Thiamin (vitamin B 1 ) (204,796,797) : Antioxidant (798) ; glucose metabolism and Krebs cycle (799) ; mental and neuronal health (800) Riboflavin (vitamin B 2 ) (204,796) : Haematopoiesis (801,802) ; gastrointestinal development (803) ; mental health (804) ; vision (805) ; cardiovascular protection (806,807) ; cancer (808,809) Niacin (vitamin B 3 ) (204,796) :…”

Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

View full text Add to dashboard Cite

Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as a-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the 'whole-grain package', and the most promising ways for improving the nutritional quality of cereal products are discussed. Whole-grain wheat: Bioactive compounds: Physiological mechanisms: Health IntroductionThere is growing evidence that whole-grain cereal products protect against the development of chronic diseases. The most important of these in terms of public health are obesity (1,2) , the metabolic syndrome (3,4) , type 2 diabetes (5,6) , CVD (7) and cancers (8 -12) . Whole-grain cereal consumption has also been shown to be protective against mortality, as was shown with inflammation-related death (i.e. noncardiovascular and non-cancer inflammatory diseases such as, for example, respiratory system diseases) (13) and with cancer and CVD (4,14,15) . These conclusions are supported by the effects of consuming refined cereal products (bread, pasta and rice), as these have been associated with an increased risk of digestive tract, pharynx, larynx and thyroid cancers in northern Italians (16) . However, an association between a lower risk of developing a chronic disease and a high whole-grain cereal consumption does not mean a direct causal relationship and provides no information about the physiological mechanisms involved.These metabolic diseases are related to our daily lifestyle, no...

show abstract

“…In one clinical study, ribo¯avin supplementation produced a three-fold increase in erythrocyte B 6 conversion, followed by a rise in a-and b-globin chain synthesis 96 . Another possibility suggested by animal studies is that ribo¯avin affects iron absorption by maintaining the absorptive capacity of gastrointestinal villi, but studies among humans have not yet observed measurable change in iron absorption following ribo¯avin supplementation 97,98 . Table 6 summarizes ribo¯avin supplementation trials that have assessed effects on anaemia.…”

Section: Ribo¯avinmentioning

confidence: 99%

The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

263

208

View full text Add to dashboard Cite

Objective: While iron de®ciency is regarded as the major cause of nutritional anaemia, changes in vitamins A, B 12 , C and E, folic acid and ribo¯avin status have also been linked to its development and control. This paper provides a systematic review of vitamin supplementation trials relating to the control of nutritional anaemia. Methods: A MEDLINE search was used to ®nd reports of vitamin supplementation trials that reported changes in anaemia or iron status. Results: Vitamin A can improve haematological indicators and enhance the ef®cacy of iron supplementation. Both folate and vitamin B 12 can cure and prevent megaloblastic anaemia. Ribo¯avin enhances the haematological response to iron, and its de®ciency may account for a signi®cant proportion of anaemia in many populations. Vitamin C enhances the absorption of dietary iron, although population-based data showing its ef®cacy in reducing anaemia or iron de®ciency are lacking. Vitamin E supplementation given to preterm infants has not reduced the severity of the anaemia of prematurity. Vitamin B 6 effectively treats sideroblastic anaemia. Multivitamin supplementation may raise haemoglobin (Hb) concentration, but few studies have isolated the effect of multivitamins from iron on haematological status. Conclusions: In general, the public health impact of vitamin supplementation in controlling anaemia is not clear. Neither are the complex interactions involving multiple vitamins in haematopoiesis suf®ciently understood to explain the observed variability in haematological responses to vitamins by age, population, vitamin mixture and dosages. Further research is needed to understand the roles of individual and combined vitamin de®ciencies on anaemia to design appropriate micronutrient interventions to prevent anaemia.

show abstract

Riboflavin Deficiency and Iron Absorption in Adult Gambian Men

Cited by 46 publications

References 7 publications

Lack of hemoglobin response to iron supplementation in anemic Mexican preschoolers with multiple micronutrient deficiencies

Lack of hemoglobin response to iron supplementation in anemic Mexican preschoolers with multiple micronutrient deficiencies

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

The role of vitamins in the prevention and control of anaemia

Contact Info

Product

Resources

About