“…[15][16][17][18] However, CXL may also have detrimental effects for infectious keratitis, since animal studies have shown that CXL reduces the permeability of the cornea to antimicrobial medications. 19 It is unclear why CXL was not effective in the present study, but it is possible that this technique could have variable efficacy depending on the organism, severity of the ulcer (eg, infiltrate depth, infiltrate diameter, stromal thinning, limbal involvement), host response, or other poorly understood factors.…”