Ribavirin as a curative and prophylactic agent against foot and mouth disease virus infection in C57BL/6 suckling and adult mice model

Nikunjkumar, Patel; Selvan, R.P. Tamil; Bhanuprakash, V.

doi:10.1007/s13337-021-00746-8

Cited by 2 publications

(6 citation statements)

References 42 publications

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“…Treatment with ribavirin in an adult mouse model (50 mg/kg/day, intraperitoneal injection, twice daily for 3 days) had an 86.67% protective efficiency before FMDV challenge and 66.67% protective efficiency after FMDV challenge. Both pre and post-treatment with ribavirin protected suckling mice (50 mg/kg, intraperitoneal injection) from lethal challenge [ 86 ]. Vaccines take time to produce protection against viruses, and the co-administration of ribavirin (1800 mg/pig) with the FMDV vaccine enhanced early antiviral resistance [ 113 ].…”

Section: Drugs Acting On 3d Polmentioning

confidence: 99%

The multiple roles of viral 3D ^pol protein in picornavirus infections

Nie,

Zhai,

Zhang

et al. 2024

Virulence

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The Picornaviridae are a large group of positive-sense, single-stranded RNA viruses, and most research has focused on the Enterovirus genus, given they present a severe health risk to humans. Other picornaviruses, such as foot-and-mouth disease virus (FMDV) and senecavirus A (SVA), affect agricultural production with high animal mortality to cause huge economic losses. The 3D pol protein of picornaviruses is widely known to be used for genome replication; however, a growing number of studies have demonstrated its non-polymerase roles, including modulation of host cell biological processes, viral replication complex assembly and localization, autophagy, and innate immune responses. Currently, there is no effective vaccine to control picornavirus diseases widely, and clinical therapeutic strategies have limited efficiency in combating infections. Many efforts have been made to develop different types of drugs to prohibit virus survival; the most important target for drug development is the virus polymerase, a necessary element for virus replication. For picornaviruses, there are also active efforts in targeted 3D pol drug development. This paper reviews the interaction of 3D pol proteins with the host and the progress of drug development targeting 3D pol .

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Section: Drugs Acting On 3d Polmentioning

confidence: 99%

The multiple roles of viral 3D ^pol protein in picornavirus infections

Nie,

Zhai,

Zhang

et al. 2024

Virulence

View full text Add to dashboard Cite

show abstract

“…In the next section, the antiviral effects of ribavirin, BQR, mizoribine, merimepodib and vesatolimod are described as possible candidates during an FMDV pandemic. Currently, a limited number of studies have reported antiviral chemical compounds for FMD ( 6 , 22 ).…”

Section: Antiviral Chemical Compoundsmentioning

confidence: 99%

“…Ribavirin . Ribavirin is an antiviral agent (synthetic purine nucleoside analog) that acts against various RNA and DNA viruses ( 6 , 22 ) ( Fig. 2 ).…”

Section: Antiviral Chemical Compoundsmentioning

confidence: 99%

“…2 ). Different serotypes of FMDV ribavirin have been demonstrated, only in vitro , to have inhibitory effects ( 22 ). Ribavirin is a promising antiviral compound.…”

Section: Antiviral Chemical Compoundsmentioning

confidence: 99%

“…Ribavirin is a promising antiviral compound. Similar to favipiravir, ribavirin interferes with viral polymerase ( 22 ) and RNA capping ( 23 ). Suckling mice have been used to investigate FMDV in lethal animal models.…”

Section: Antiviral Chemical Compoundsmentioning

confidence: 99%

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Antiviral agents and disinfectants for foot‑and‑mouth disease (Review)

et al. 2023

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Fluorouracil, ribavirin, and its derivative (T-1105) exhibit anti-foot-and-mouth disease virus (FMDV) effects. In particular, T-1105 exhibits promising results when administered to guinea pigs orally, and pigs in their feed. FMDV is excreted in the early stages of infection in aerosols and oral or nasal droplets from animals. T-1105 along with the FMDV vaccine can be used to combat foot-and-mouth disease (FMD) epidemics. Several studies have shown that sodium hypochlorous solutions are widely used to inactivate viruses, including FMDV. However, these solutions must be stored under cool and dark conditions to maintain their virucidal effects. Interestingly, a study indicated that the virucidal activity of a calcium bicarbonate solution with a mesoscopic structure (CAC-717) did not decrease after storage at room temperature for at least four years outside direct sunlight. Numerous lessons acquired from the 2010 FMD outbreak in Japan are relevant for the control of COVID-19. However, the widespread use of chlorite can cause environmental issues. Chlorite can be combined with nitrogen to produce chloramine or N-nitrosodimethylamine, which plays a role in carcinogenesis. Therefore, risk assessments should be conducted in aquatic environments. Moreover, there is a need to develop nonchlorine disinfectants that can be used during epidemics, including FMD. The approach of 'One Health' should be shared between the public health and veterinary fields to improve the management of viral outbreaks, including those due to FMD. Contents 1. Introduction 2. Antiviral chemical compounds 3. Disinfectants for use against environmental contaminants 4. Foot-and-mouth disease and environmental contamination 5. Discussion 6. Conclusion

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Ribavirin as a curative and prophylactic agent against foot and mouth disease virus infection in C57BL/6 suckling and adult mice model

Cited by 2 publications

References 42 publications

The multiple roles of viral 3D ^pol protein in picornavirus infections

The multiple roles of viral 3D ^pol protein in picornavirus infections

Antiviral agents and disinfectants for foot‑and‑mouth disease (Review)

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Ribavirin as a curative and prophylactic agent against foot and mouth disease virus infection in C57BL/6 suckling and adult mice model

Cited by 2 publications

References 42 publications

The multiple roles of viral 3D pol protein in picornavirus infections

The multiple roles of viral 3D pol protein in picornavirus infections

Antiviral agents and disinfectants for foot‑and‑mouth disease (Review)

Contact Info

Product

Resources

About

The multiple roles of viral 3D ^pol protein in picornavirus infections

The multiple roles of viral 3D ^pol protein in picornavirus infections