Rhythmusstörungen bei chronischem Cor pulmonale

Schüren, K. P.; Calder, D.; Hüttemann, U.

doi:10.1055/s-0028-1107203

Cited by 12 publications

(1 citation statement)

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“…The effects of nitroglycerin on the systemic circulation are well known, and as regards pulmonary circulation, the decreased PAP observed during intravenous administration of nitroglycerin in two recent studies [5,6]. This may have been due to a concomitant decrease of cardiac output [22] and PVR [23]. In the present study, we used a nitroglycerin dose of 1 and 2.5 Ìg/kg/min.…”

Section: Discussionmentioning

confidence: 99%

Effects of Inhalation of Nitroglycerin on Hypoxic Pulmonary Vasoconstriction

Bando

Ishii²,

Kitamura³

et al. 1998

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Recent studies suggest that nitric oxide (NO) may play an important role in the pathophysiology of pulmonary hypertension. Nitroglycerin is metabolized to NO, which is a potent vascular smooth muscle relaxant. The aim of the present study was to compare the effects of inhaled and infused nitroglycerin on pulmonary hemodynamics and gas exchange in anesthetized, artificially ventilated dogs. Nitroglycerin was administrated either by inhalation or by infusion. Systemic blood pressure (SBP), pulmonary arterial pressure (PAP), and pulmonary capillary wedge pressure (PCWP) were measured, and cardiac output was estimated by an electromagnetic flowmeter. Blood gas measurements were performed during hypoxic gas exposure (FiO₂; 0.1) with a continuous inhalation or infusion of nitroglycerin (1, 2.5 µg/kg/min). Inhaled (n = 4) and infused (n = 4) nitroglycerin (1 µg/kg/min) did not produce any detectable effects on the hemodynamics. Inhaled nitroglycerin (2.5 µg/kg/min) reduced SBP, PAP and calculated pulmonary vascular resistance (PVR) in all dogs. Cardiac output did not change. In addition, inhaled nitroglycerin increased PaO₂. In contrast, the continuous infusion of nitroglycerin (2.5 µg/kg/min) did not change in PAP, whereas infused nitroglycerin decreased the mean SBP. Infused nitroglycerin did not alter cardiac output and calculated PVR. A decreased PaO₂ was noted in 2 dogs on nitroglycerin infusion. These findings indicate that inhaled nitroglycerin effects the pulmonary circulation relatively more than infused nitroglycerin, which tends to have more of a general effect on the systemic circulation. The effects of inhaled nitroglycerin may thus be comparable to the effects of NO inhalation.

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