Rhythms of Protein Synthesis and Other Circahoralian Oscillations: The Possible Involvement of Fractals

Brodsky, V. Ya.

doi:10.1007/978-1-4471-1969-2_2

Cited by 18 publications

(14 citation statements)

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“…Thus, the rhythmic rise and fall of ATP content was unrelated to mitotic cycle. The same conclusion was reached from the detection of a similar ATP rhythm in hepatocytes (Brodsky et al, 1992), which undergo almost no cell division. Ultradian rhythms of cAMP levels were shown in slices of the rat parotid gland (Yarigin et al, 1979) and sea urchin blastomeres (Yasumasu et al, 1973).…”

Section: Introductionsupporting

confidence: 76%

“…A cell-free system from the liver was created twenty years ago as a postmitochondrial supernatant with the addition of ATP, GTP, amino acids and some other components (Eisenstein & Harper, 1984). In this system, an ultradian rhythm of protein synthesis was observed, like that found in hepatocytes cultured in vitro (Boikov, 1987 ;Brodsky et al, 1992). Ultradian and minute irregular rhythms of lactate dehydrogenase isozyme activity were also detected in cultured erythroleukaemic cells and in the corresponding cell-free system (Ferreira et al, 1996).…”

Section: Nature Of Intracellular Ultradian Rhythmsmentioning

confidence: 79%

“…In one study of Lloyd's group more than 20 successive ultradian periods were observed to occur without damping. This robustness was noted for ultradian rhythms of pH value and ATP levels in rat hepatocytes in vitro (Litinskaya et al, 1987;Brodsky et al, 1992). The ultradian protein synthesis rhythm was retained after pH changes of 0.5 from the mean pH value in hepatocytes.…”

Section: Nature Of Intracellular Ultradian Rhythmsmentioning

confidence: 81%

“…In a previous autoradiographic study, ultradian rhythms of 3 H-leucine incorporation were also described in photoreceptors, bipolar and ganglion cells of the same retina, and the oscillations were synphasic (Kunina, 1977 ;Brodsky, 1992). 3 Slices of the rat parotid gland were obtained from one gland in each experiment (Brodsky et al, 1967 ;Brodsky, 1992). 4 Hepatocytes were isolated from the rat liver and cultivated 1-2 days before estimation of protein synthesis kinetics (Brodsky et al, 1983(Brodsky et al, , 1994(Brodsky et al, , 2003a(Brodsky et al, , b, 2004.…”

Section: Nature Of Intracellular Ultradian Rhythmsmentioning

confidence: 91%

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Direct cell–cell communication: a new approach derived from recent data on the nature and self-organisation of ultradian (circahoralian) intracellular rhythms

Brodsky

2005

Biol. Rev.

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Recent data concerning ultradian (circahoralian) intracellular rhythms are used to assess the biochemical mechanisms of direct cell-cell communication. New results and theoretical considerations suggest a fractal nature of ultradian rhythms and their self-organisation. The fundamental and innate nature of these rhythms relates to their self-similarity at different levels of cell and tissue organisation. They can be detected in cell-free systems as well as in cells and organs in vivo. Such rhythms are a means of finding an optimal state of cell function rather than achieving a state of absolute stability. As a consequence, oscillations, being irregular and numerous by the set of periods, are resilient to functional overload and injury. Recent data on the maintenance of their fractal structure and, especially on the selection of optimal periods are discussed. The positive role of chaotic dynamics is stressed. The ultradian rhythm of protein synthesis in hepatocytes in vitro was used as a marker of direct cell-cell communication. The system demonstrates cell cooperation and synchronisation throughout the cell population, and suggests that the ultradian rhythms are self-organised. These observations also led to the detection of mechanisms of direct cell-cell communication in which extracellular factors have an essential role. Experimental evidence indicated the involvement of gangliosides and/or catecholamines in this large-scale synchronisation of protein synthesis. The response of all, or a major part, of the cell population is important; after the initial trigger effect, a periodic pattern is retained for some time. The influence of Ca2+-dependent protein kinases on protein phosphorylation can be a final step in the phase modulation of rhythms during cell-cell synchronisation. The intercellular medium plays an important role in self-synchronisation of ultradian rhythms between individual cells. Low cooperative activity of hepatocytes of old rats resulted from altered composition of the intercellular medium rather than direct effects of animal and cellular ageing. Similarly, in the whole body, changes in levels of gangliosides and catecholamines in the blood serum, a natural intercellular medium, can be critical events in age-dependent changes of the serum and accordingly cell-cell synchronisation. Hepatocytes of old rats exhibit some of the properties of young cells following an increase in blood serum ganglioside level, as well as, in in vitro conditions, after the addition of gangliosides to the culture medium. Together with data on ultradian functional and metabolic rhythms, all the material reviewed here allows us to propose a mechanism of direct cell-cell cooperation via the medium in which the cells exist, that supplements the nervous and hormonal central regulation of organ functions. Ultradian intracellular rhythms may thus provide a finer framework within which the integrated dynamics of respiration, heart rate, brain activity, and even behavioural patterns, are brought to an optimal functional pattern. I...

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Section: Introductionsupporting

confidence: 76%

Section: Nature Of Intracellular Ultradian Rhythmsmentioning

confidence: 79%

Section: Nature Of Intracellular Ultradian Rhythmsmentioning

confidence: 81%

Section: Nature Of Intracellular Ultradian Rhythmsmentioning

confidence: 91%

See 2 more Smart Citations

Direct cell–cell communication: a new approach derived from recent data on the nature and self-organisation of ultradian (circahoralian) intracellular rhythms

Brodsky

2005

Biol. Rev.

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“…Тем не менее, они ведут себя как регуляторные осцилляторы, и их следует рассматривать как важнейший компонент временной организации тканей. В связи с этим, ультрадианные ритмы могут служить не только надежным маркером морфологической зрелости, но и функциональной активности ткани [8], а так же позволяют выявить выраженный токсический эффект.…”

Section: Introductionunclassified

Ecological adaptation of the rhythmic activity of plasma proteins in experiment

Rozhkova¹

2018

Scientific Achievements of the Third Millennium

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An appreciation of the prescience of Don Gilbert (1930–2011): master of the theory and experimental unravelling of biochemical and cellular oscillatory dynamics

Gilbert

Hammond²,

Brodsky

et al. 2020

Cell Biology International

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We review Don Gilbert's pioneering seminal contributions that both detailed the mathematical principles and the experimental demonstration of several of the key dynamic characteristics of life. Long before it became evident to the wider biochemical community, Gilbert proposed that cellular growth and replication necessitate autodynamic occurrence of cycles of oscillations that initiate, coordinate and terminate the processes of growth, during which all components are duplicated and become spatially re‐organised in the progeny. Initiation and suppression of replication exhibit switch‐like characteristics, that is, bifurcations in the values of parameters that separate static and autodynamic behaviour. His limit cycle solutions present models developed in a series of papers reported between 1974 and 1984, and these showed that most or even all of the major facets of the cell division cycle could be accommodated. That the cell division cycle may be timed by a multiple of shorter period (ultradian) rhythms, gave further credence to the central importance of oscillatory phenomena and homeodynamics as evident on multiple time scales (seconds to hours). Further application of the concepts inherent in limit cycle operation as hypothesised by Gilbert more than 50 years ago are now validated as being applicable to oscillatory transcript, metabolite and enzyme levels, cellular differentiation, senescence, cancerous states and cell death. Now, we reiterate especially for students and young colleagues, that these early achievements were even more exceptional, as his own lifetime's work on modelling was continued with experimental work in parallel with his predictions of the major current enterprises of biological research.

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Rhythms of Protein Synthesis and Other Circahoralian Oscillations: The Possible Involvement of Fractals

Cited by 18 publications

References 59 publications

Direct cell–cell communication: a new approach derived from recent data on the nature and self-organisation of ultradian (circahoralian) intracellular rhythms

Direct cell–cell communication: a new approach derived from recent data on the nature and self-organisation of ultradian (circahoralian) intracellular rhythms

Ecological adaptation of the rhythmic activity of plasma proteins in experiment

An appreciation of the prescience of Don Gilbert (1930–2011): master of the theory and experimental unravelling of biochemical and cellular oscillatory dynamics

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