Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle

Li, Yong; Liu, Yun‐Bao; Yan, Huimin; Liu, Yang-Lan; Li, Yuhuan; Lv, Haining; Ma, Shuang‐Gang; Qu, Jing; Yu, Shi‐Shan

doi:10.1038/srep36752

Cited by 19 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rhodomollin B ( 142 ) from Rhododendron molle fruits showed inhibitory activity of Influenza A95 / 359 virus with an IC 50 value of 19.24 μM ( Li et al, 2016 ). Trichoderma atroviride containing wickerols A and B (200-201) had anti-influenza virus H1N1 strain with IC 50 values 5.0 μg/ml and 0.07 μg/ml.…”

Section: Influenza Virusmentioning

confidence: 99%

Potential of diterpene compounds as antivirals, a review

Wardana¹,

Aminah²,

Rosyda³

et al. 2021

Heliyon

View full text Add to dashboard Cite

Viruses cause widely transmitted diseases resulting in pandemic conditions. Currently, the world is being hit by the Covid-19 pandemic caused by the SAR-CoV-2 infection. Countries in the world are competing to develop antivirals to overcome this problem. Diterpene compounds derived from natural ingredients (plants, corals, algae, fungi, sponges) and synthesized products have potential as antivirals. This article summarizes the different types of diterpenes such as daphnane, tiglilane, kaurane, abietane, pimarane, labdane, dollabelane, jatrophane, dolastane, prenylated guaiane, tonantzitlolone, casbane, have antivirals activity such as targeting HIV, Coxsackie virus, herpes virus, hepatitis virus, influenza virus, Chikungunya virus, Zika virus, dengue virus, and SARS-CoV. Some compounds such as andrographolide and its derivatives show promising activity in inhibiting the influenza virus. Additionally, compounds such as pineolidic acid, forskolin, sugiol, and many other diterpene compounds showed anti-SAR-CoV activity. The diterpene compound class's high antivirals potential does not rule out the possibility that these compounds can also act as anti-SAR-CoV-2 drugs in the future

show abstract

Section: Influenza Virusmentioning

confidence: 99%

Potential of diterpene compounds as antivirals, a review

Wardana¹,

Aminah²,

Rosyda³

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

“…The Ericaceae plants have high values in aesthetics and medicine with worldwide distribution. They contain a wide range of chemical components such as flavones 1 , diterpenes 2 – 4 , triterpenes 5 , phenols 6 , coumarins 7 , and lignans 8 , 9 which possess pharmacological activities that include anti-inflammatory 10 , analgesic 2 – 4 , anti-oxidant 11 , anti-bacterial 11 , anti-HIV 12 , immunity 13 , and cytotoxicity 14 properties.…”

Section: Introductionmentioning

confidence: 99%

“…To date, only two literature articles describing chemical investigations of this plant have been published, and mostly considered the phenols and iridoids 16 , 17 . The previous work carried out by our group over the years led to the isolation of new active terpenoids from plants of the family Ericaceae 2 – 4 , 18 , 19 . Therefore, our research on this plant was mainly focused on the attractive terpenoids.…”

Section: Introductionmentioning

confidence: 99%

Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Liu

Wang

et al. 2017

Sci Rep

Self Cite

View full text Add to dashboard Cite

Rhodoterpenoids A‒C (1‒3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography−mass spectrometry−solid-phase extraction−nuclear magnetic resonance (HPLC‒MS‒SPE‒NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1‒4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC50 values of 8.62 and 6.87 μM, respectively.

show abstract

“…Rhododendron molle G. Don (Ericaceae) is a well-known medicinal plant for treating pain, rheumatism, and asthma, as well as bruises, and its flowers, fruits, and roots have been proven to be a rich source of grayanane and related diterpenoids . However, phytochemical investigations on the leaves of R. molle are rare, and only a rhodomollane, three 2,3:5,6-di- seco -grayanane, and related grayanane diterpenoids were recently reported by our group .…”

mentioning

confidence: 99%

Mollebenzylanols A and B, Highly Modified and Functionalized Diterpenoids with a 9-Benzyl-8,10-dioxatricyclo[5.2.1.0^1,5]decane Core from Rhododendron molle

et al. 2018

View full text Add to dashboard Cite

Two highly modified and functionalized diterpenoids, mollebenzylanols A (1) and B (2), and a known grayanane diterpenoid rhodojaponin III (3) were isolated from Rhododendron molle. Their structures were determined by spectroscopic data analysis, an electronic circular dichroism (ECD) exciton chirality method, ECD calculations, and X-ray diffraction analysis of the p-bromobenzoate ester of 1 (1a). Compounds 1 and 2 possess an unprecedented diterpene carbon skeleton featuring a unique 9-benzyl-8,10-dioxatricyclo[5.2.1.0]decane core, and their plausible biosynthetic pathways are proposed. Their PTP1B inhibitory activity and modes of action were investigated.

show abstract

Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle

Cited by 19 publications

References 21 publications

Potential of diterpene compounds as antivirals, a review

Potential of diterpene compounds as antivirals, a review

Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Mollebenzylanols A and B, Highly Modified and Functionalized Diterpenoids with a 9-Benzyl-8,10-dioxatricyclo[5.2.1.0^1,5]decane Core from Rhododendron molle

Contact Info

Product

Resources

About

Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle

Cited by 19 publications

References 21 publications

Potential of diterpene compounds as antivirals, a review

Potential of diterpene compounds as antivirals, a review

Rhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR

Mollebenzylanols A and B, Highly Modified and Functionalized Diterpenoids with a 9-Benzyl-8,10-dioxatricyclo[5.2.1.01,5]decane Core from Rhododendron molle

Contact Info

Product

Resources

About

Mollebenzylanols A and B, Highly Modified and Functionalized Diterpenoids with a 9-Benzyl-8,10-dioxatricyclo[5.2.1.0^1,5]decane Core from Rhododendron molle