Viruses cause widely transmitted diseases resulting in pandemic conditions. Currently, the world is being hit by the Covid-19 pandemic caused by the SAR-CoV-2 infection. Countries in the world are competing to develop antivirals to overcome this problem. Diterpene compounds derived from natural ingredients (plants, corals, algae, fungi, sponges) and synthesized products have potential as antivirals. This article summarizes the different types of diterpenes such as daphnane, tiglilane, kaurane, abietane, pimarane, labdane, dollabelane, jatrophane, dolastane, prenylated guaiane, tonantzitlolone, casbane, have antivirals activity such as targeting HIV, Coxsackie virus, herpes virus, hepatitis virus, influenza virus, Chikungunya virus, Zika virus, dengue virus, and SARS-CoV. Some compounds such as andrographolide and its derivatives show promising activity in inhibiting the influenza virus. Additionally, compounds such as pineolidic acid, forskolin, sugiol, and many other diterpene compounds showed anti-SAR-CoV activity. The diterpene compound class's high antivirals potential does not rule out the possibility that these compounds can also act as anti-SAR-CoV-2 drugs in the future

Secondary metabolite compounds have a very diverse structure that is widely used as a source of new drug discovery because they have a variety of bioactivity. But in its development, there are several problems related to these compounds including low bioavailability, low solubility and instability in the metabolic process. Modification of the structure of secondary metabolites is used to answer all these problems. One of the processed was by synthesising the ester derivative compounds through the chemical and enzymatic esterification reaction. Esters derivatives of secondary metabolite compounds can increase the diversity of structures, allow for increased biological activity and even new biological activity of these compounds. This review will discuss various processes of modification of the structure of secondary metabolite compounds through chemical and enzymatic esterification reactions that have been reported from 1994-2019.