Rhodnius prolixus intoxicated

Alzogaray, Raúl A.; Zerba, Eduardo

doi:10.1016/j.jinsphys.2016.04.004

Cited by 16 publications

(16 citation statements)

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“…However, during our tests we did not observe any symptoms of intoxication (i.e. insects with abnormal rest positions, paralysis in the legs, or death [19]) due to sulfur compounds perhaps because of the low doses tested or because the insect never got in direct contact with the compounds tested. Nevertheless, the effects of these sulfur compounds on development, hatching, oviposition or molting of insects, sensory adaptation, or the toxicity to vertebrate animals and humans should be studied for future applications.…”

Section: Discussionmentioning

confidence: 58%

“…Historically, most research on repellents has focused on mosquitoes over other blood-sucking arthropods such as triatomines [4,[15][16][17][18][19][20][21]. This tendency to focus on mosquito-repellent research is not surprising considering the higher mortality and morbidity due to mosquito-borne diseases compared to that of Chagas disease [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, the effectiveness of DEET against all groups of biting arthropods, triatomines included, has granted it the title of the gold standard among repellents [4,5]. However, compared with mosquitoes and other blood-sucking arthropods, triatomines have a lower sensitivity to this repellent [19,26]. Studies with R. prolixus and T. infestans have revealed that whether the host is present or not, only high doses (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Novel repellents for the blood-sucking insects Rhodnius prolixus and Triatoma infestans, vectors of Chagas disease

et al. 2020

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Background: Studying the behavioral response of blood-sucking disease-vector insects to potentially repellent volatile compounds could shed light on the development of new control strategies. Volatiles released by human facial skin microbiota play different roles in the host-seeking behavior of triatomines. We assessed the repellency effect of such compounds of bacterial origin on Triatoma infestans and Rhodnius prolixus, two important vectors of Chagas disease in Latin America. Methods: Using an exposure device, insects were presented to human odor alone (control) and in the presence of three individual test compounds (2-mercaptoethanol, dimethyl sulfide and 2-phenylethanol, the latter only tested in R. prolixus) and the gold-standard repellent NN-diethyl-3-methylbenzamide (DEET). We quantified the time the insects spent in the proximity of the host and determined if any of the compounds evaluated affected the behavior of the insects. Results: We found volatiles that significantly reduced the time spent in the proximity of the host. These were 2-phenylethanol and 2-mercaptoethanol for R. prolixus, and dimethyl sulfide and 2-mercaptoethanol for T. infestans. Such an effect was also observed in both species when DEET was presented, although only at the higher doses tested. Conclusions: The new repellents modulated the behavior of two Chagas disease vectors belonging to two different triatomine tribes, and this was achieved using a dose up to three orders of magnitude lower than that needed to evoke the same effect with DEET. Future efforts in understanding the mechanism of action of repellent compounds such as 2-mercaptoethanol, as well as an assessment of their temporal and spatial repellent properties, could lead to the development of novel control strategies for these insect vectors, refractory to DEET.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Novel repellents for the blood-sucking insects Rhodnius prolixus and Triatoma infestans, vectors of Chagas disease

et al. 2020

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“…However, in addition to the repellency effect, we did not identify any symptoms of intoxication (i.e., insects with abnormal rest positions, paralysis in the legs or death. [15]) due to sulfur compounds in our experiments, perhaps because of the low doses tested; nevertheless, the toxicity of these sulfur compounds to animals and humans should be reviewed carefully for future applications.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the effectiveness of DEET against all groups of biting arthropods, triatomines included, has granted it the title of the gold standard among repellents [4,5]. However, compared with mosquitoes and other blood-sucking arthropods, triatomines have a lower sensitivity to this repellent [15,22]. Studies with R. prolixus and T. infestans have revealed that whether the host is present or not, only high doses (i.e., >90%) have a repellent effect, making DEET rather impractical for reducing human-vector contacts [11,23–26].…”

Section: Introductionmentioning

confidence: 99%

Novel repellents for the blood-sucking insectsRhodnius prolixusandTriatoma infestans, vectors of Chagas disease

Ramírez

Ortiz

Guerenstein

et al. 2019

Preprint

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24 25 Background: Studying the behavioral response of blood-sucking, disease-vector insects to 26 potentially repellent volatile compounds could shed light on the development of new 27 control strategies. Volatiles released by human facial skin microbiota play different roles in 28 the host-seeking behavior of triatomines. We assessed the repellency effect of such 29 compounds of bacterial origin on Triatoma infestans and Rhodnius prolixus, two important 30 vectors of Chagas disease in Latin America. 31 Methods: Using an exposure device, insects were presented to human odor alone (negative 32 control) and in the presence of three individual tested compounds (2-mercaptoethanol, 33 dimethyl sulfide and 2-phenylethanol, which was only tested in R. prolixus) and the gold-34 standard repellent NN-diethyl-3-methylbenzamide-DEET (positive control). We quantified 35 the time the insects spent in the proximity of the host and performed nonparametric 36 statistical tests to determine if any of the compounds evaluated affected the behavior of the 37 insect. 38Results: We found volatiles that significantly reduced the time spent in the proximity of the 39 host. These were 2-phenylethanol and 2-mercaptoethanol for R. prolixus, and dimethyl 40 sulfide and 2-mercaptoethanol for T. infestans. Such an effect was also observed in both 41 species when DEET was presented, although only at the higher doses tested. 42 Conclusions:The new repellents modulated the behavior of two Chagas disease vectors 43 belonging to two different triatomine tribes, and this was achieved using a dose up to three 44 orders of magnitude lower than that needed to evoke the same effect with DEET. Future 45 efforts in understanding deeply the mechanism of action of repellent compounds such as 2-46 3 mercaptoethanol, as well as an assessment of their temporal and spatial repellent properties, 47 could lead to the development of novel control strategies for insect vectors refractory to 48 DEET. 49

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Benefits, Future Prospective, and Problem Associated with the Use of Nanopesticides

Muneer

Zia

Zaheer

et al. 2023

Nanomaterials for Environmental and Agricultural Sectors

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Rhodnius prolixus intoxicated

Cited by 16 publications

References 204 publications

Novel repellents for the blood-sucking insects Rhodnius prolixus and Triatoma infestans, vectors of Chagas disease

Novel repellents for the blood-sucking insects Rhodnius prolixus and Triatoma infestans, vectors of Chagas disease

Novel repellents for the blood-sucking insectsRhodnius prolixusandTriatoma infestans, vectors of Chagas disease

Benefits, Future Prospective, and Problem Associated with the Use of Nanopesticides

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